Pde4dip phosphodiesterase 4D interacting protein (myomegalin) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pde4dipprovided by MGI
Official Full Name: phosphodiesterase 4D interacting protein (myomegalin)provided by MGI
Primary source: MGI:MGI:1891434
See related: Ensembl:ENSMUSG00000038170 AllianceGenome:MGI:1891434
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Usmg4; mKIAA0454; D3Bwg1078e; 4732458A06Rik; 9430063L05Rik; D130016K21Rik
Summary: Predicted to enable enzyme binding activity and molecular adaptor activity. Predicted to be involved in microtubule cytoskeleton organization; protein-containing complex assembly; and regulation of organelle organization. Predicted to be located in myofibril and nucleus. Predicted to be active in Golgi apparatus and centrosome. Predicted to colocalize with cortical microtubule plus-end. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human PDE4DIP (phosphodiesterase 4D interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in heart adult (RPKM 75.3), mammary gland adult (RPKM 16.2) and 13 other tissues See more
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Genomic context

Location:: 3 F2.2; 3 42.28 cM

Exon count:: 48

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (97597144..97796023, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (97689828..97888707, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D3Mit41 (e-PCR), detects polymorphism
- UniSTS:129809

D3Bwg1078e (e-PCR), detects polymorphism
- UniSTS:142383

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

D3Mit233 (e-PCR), detects polymorphism
- UniSTS:129653

RH125170 (e-PCR)
- UniSTS:161992

Pde4dip (e-PCR), detects polymorphism
- UniSTS:507125

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in astral microtubule organization	ISO Inferred from Sequence Orthology more info
involved_in centrosome cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of microtubule nucleation	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of Golgi organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of Golgi organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of Golgi organization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info	PubMed
colocalizes_with cortical microtubule plus-end	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in myofibril	ISO Inferred from Sequence Orthology more info
located_in myofibril	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: myomegalin

Names: phosphodiesterase 4D-interacting protein; upregulated during skeletal muscle growth 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039376.2 → NP_001034465.2 myomegalin isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 5. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 5.

Source sequence(s)

AA727946, AC130541, AK122286, BB636676, BC028274, BC046620, BM950385, BQ042855, BQ554472, BU613416, BX517394, CB523595, CF532518, CO428791, CO432192, CR757260

UniProtKB/TrEMBL

B2RUJ9

Conserved Domains (4) summary

TIGR02168
Location:123 → 770

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam06758
Location:1684 → 1745

DUF1220; Repeat of unknown function (DUF1220)

pfam07851
Location:362 → 457

TMPIT; TMPIT-like protein

pfam07989
Location:126 → 193

Cnn_1N; Centrosomin N-terminal motif 1
NM_001289701.1 → NP_001276630.1 myomegalin isoform 5

See identical proteins and their annotated locations for NP_001276630.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) represents the longest transcript and encodes the longest isoform (5).

Source sequence(s)

AC130541, AC131746, AC153661

Consensus CDS

CCDS79985.1

UniProtKB/TrEMBL

B2RUJ9, G3X9L9

Related

ENSMUSP00000088254.6, ENSMUST00000090750.12

Conserved Domains (4) summary

TIGR02168
Location:123 → 770

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam06758
Location:1684 → 1745

DUF1220; Repeat of unknown function (DUF1220)

pfam07851
Location:362 → 457

TMPIT; TMPIT-like protein

pfam07989
Location:126 → 193

Cnn_1N; Centrosomin N-terminal motif 1
NM_001289702.1 → NP_001276631.1 myomegalin isoform 6

Status: VALIDATED

Description

Transcript Variant: This variant (6) lacks an alternate in-frame exon compared to variant 5. The resulting isoform (6) has the same N- and C-termini but is shorter compared to isoform 5.

Source sequence(s)

AC130541, AC131746, AC153661

Consensus CDS

CCDS79984.1

UniProtKB/TrEMBL

B7ZNY0, E9Q1A0

Related

ENSMUSP00000131170.3, ENSMUST00000168438.9

Conserved Domains (4) summary

TIGR02168
Location:123 → 770

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam06758
Location:1684 → 1745

DUF1220; Repeat of unknown function (DUF1220)

pfam07851
Location:362 → 457

TMPIT; TMPIT-like protein

pfam07989
Location:126 → 193

Cnn_1N; Centrosomin N-terminal motif 1
NM_178080.4 → NP_835181.2 myomegalin isoform 2

See identical proteins and their annotated locations for NP_835181.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) has multiple differences in the UTRs and coding region compared to variant 5. The resulting isoform (2) has much shorter and distinct N- and C-termini compared to isoform 5.

Source sequence(s)

BC050783, BU506330, CJ127389

Consensus CDS

CCDS38562.1

UniProtKB/Swiss-Prot

Q80YT7

Related

ENSMUSP00000040905.9, ENSMUST00000045243.15

Conserved Domains (3) summary

PRK02224
Location:637 → 1116

PRK02224; chromosome segregation protein; Provisional

pfam07776
Location:4 → 78

zf-AD; Zinc-finger associated domain (zf-AD)

pfam07851
Location:405 → 500

TMPIT; TMPIT-like protein

RNA

NR_110360.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (7) has multiple differences compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC153661, AK122286, BC057350, BP760882

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

97597144..97796023 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001110163.1: Suppressed sequence

Description

NM_001110163.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
NM_031401.2: Suppressed sequence

Description

NM_031401.2: This RefSeq was permanently suppressed because it comprises 3' UTR sequence and does not encode any part of the Pde4dip protein.
NM_177145.3: Suppressed sequence

Description

NM_177145.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.