TOC1 CCT motif -containing response regulator protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: TOC1
Official Full Name: CCT motif -containing response regulator protein
Primary source: TAIR:AT5G61380
Locus tag: AT5G61380
See related: Araport:AT5G61380
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: APRR1; AtTOC1; MFB13.13; MFB13_13; PRR1; PSEUDO-RESPONSE REGULATOR 1; TIMING OF CAB EXPRESSION 1
Summary: Pseudo response regulator involved in the generation of circadian rhythms. TOC1 appears to shorten the period of circumnutation speed. TOC1 contributes to the plant fitness (carbon fixation, biomass) by influencing the circadian clock period. PRR3 may increase the stability of TOC1 by preventing interactions between TOC1 and the F-box protein ZTL. Expression of TOC1 is correlated with rhythmic changes in chromatin organization.
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Genomic context

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See TOC1 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 6

Sequence:: Chromosome: 5; NC_003076.8 (24674963..24678550)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Arabidopsis seeds altered in the circadian clock protein TOC1 are characterized by higher level of linolenic acid.
Title: Arabidopsis seeds altered in the circadian clock protein TOC1 are characterized by higher level of linolenic acid.
ZTL regulates thermomorphogenesis through TOC1 and PRR5.
Title: ZTL regulates thermomorphogenesis through TOC1 and PRR5.
HDA9 specifically binds to the TOC1 promoter through the interaction with ELF3. The EC-HDA9 complex promotes H3 deacetylation at the TOC1 locus, contributing to suppressing TOC1 expression during the night.
Title: The EC-HDA9 complex rhythmically regulates histone acetylation at the TOC1 promoter in Arabidopsis.
deregulates reactive oxygen species levels and leads to fine-tuning trade-offs between reproductive success and defence responses
Title: FITNESS, a CCT domain-containing protein, deregulates reactive oxygen species levels and leads to fine-tuning trade-offs between reproductive success and defence responses in Arabidopsis.
The interaction between TOC1 and PIF4 mediates the circadian gating of thermoresponsive growth.
Title: TOC1-PIF4 interaction mediates the circadian gating of thermoresponsive growth in Arabidopsis.
The germination mediated by phytochrome B requires the presence of functional PSEUDO-RESPONSE REGULATOR 7 (PRR7) and TIMING OF CAB EXPRESSION 1 (TOC1) alleles.
Title: Physiological and molecular mechanisms underlying the integration of light and temperature cues in Arabidopsis thaliana seeds.
Data report that COR27 and COR28 bind to the chromatin of TOC1 and PRR5 to repress their transcription, suggesting that their effects on rhythms are in part due to their regulation of TOC1 and PRR5 These data demonstrate that blue light and low temperature-regulated COR27 and COR28 regulate the circadian clock as well as freezing tolerance and flowering time.
Title: Blue Light- and Low Temperature-Regulated COR27 and COR28 Play Roles in the Arabidopsis Circadian Clock.
TOC1 functions to provide a direct output from the core clock that transiently constrains the growth-promoting activity of the accumulating PIFs early postdusk, thereby gating growth to predawn, when conditions for cell elongation are optimal.
Title: Molecular convergence of clock and photosensory pathways through PIF3-TOC1 interaction and co-occupancy of target promoters.
Results show that TOC1 and CCA1 mRNA transcription levels are regulated by the newly identified Hesp gene and suggest a deadenylation as a mechanism involved in the regulation of the circadian clock.
Title: AtHESPERIN: a novel regulator of circadian rhythms with poly(A)-degrading activity in plants.
LNK1 is a transcriptional coactivator necessary for expression of the clock genes PRR5 and TOC1 through recruitment to their promoters via interaction with bona fide DNA binding proteins such as RVE4 and RVE8.
Title: LNK1 and LNK2 are transcriptional coactivators in the Arabidopsis circadian oscillator.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_125531.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphorelay response regulator activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
NOT enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within circadian rhythm	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within circumnutation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytokinin-activated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info
located_in nucleus	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: CCT motif -containing response regulator protein

NP_200946.1

TIMING OF CAB EXPRESSION 1 (TOC1); CONTAINS InterPro DOMAIN/s: CheY-like (InterPro:IPR011006), Signal transduction response regulator, receiver domain (InterPro:IPR001789), CCT domain (InterPro:IPR010402); BEST Arabidopsis thaliana protein match is: pseudo-response regulator 3 (TAIR:AT5G60100.3); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

24674963..24678550

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_125531.4 → NP_200946.1 CCT motif -containing response regulator protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_200946.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9LKL2, Q9M4B7

UniProtKB/TrEMBL

A0A178UC73, A0A5S9YIB6, A0A7G2FIR6

Conserved Domains (2) summary

cd17582
Location:21 → 124

psREC_PRR; pseudo receiver domain of pseudo-response regulators

pfam06203
Location:533 → 575

CCT; CCT motif