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    Vdac3 voltage-dependent anion channel 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83532, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vdac3provided by RGD
    Official Full Name
    voltage-dependent anion channel 3provided by RGD
    Primary source
    RGD:621577
    See related
    EnsemblRapid:ENSRNOG00000019277 AllianceGenome:RGD:621577
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable voltage-gated monoatomic anion channel activity. Predicted to be involved in sperm mitochondrial sheath assembly. Predicted to act upstream of or within behavioral fear response; learning; and neuron-neuron synaptic transmission. Located in synaptic vesicle. Orthologous to human VDAC3 (voltage dependent anion channel 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 3554.8), Heart (RPKM 3191.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Vdac3 in Genome Data Viewer
    Location:
    16q12.5
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (76137489..76153933)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (69434982..69451473)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (74292466..74308910)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene DNA polymerase beta Neighboring gene dickkopf WNT signaling pathway inhibitor 4 Neighboring gene voltage-dependent anion channel 3 like 1 Neighboring gene solute carrier family 20 member 2 Neighboring gene uncharacterized LOC120097400 Neighboring gene small integral membrane protein 19

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of rat porin isoforms: cloning of a cardiac type-3 variant encoding an additional methionine at its putative N-terminal region. Anflous K, et al. Biochim Biophys Acta, 1998 Jul 30. PMID 9714728
    2. Characterization of porin isoforms expressed in tumor cells. Shinohara Y, et al. Eur J Biochem, 2000 Oct. PMID 10998068
    3. All three isoforms of the voltage-dependent anion channel (VDAC1, VDAC2, and VDAC3) are present in mitochondria from bovine, rabbit, and rat brain. Cesar Mde C, et al. Arch Biochem Biophys, 2004 Feb 15. PMID 14759607
    4. The role of mitochondrial porins and the permeability transition pore in learning and synaptic plasticity. Weeber EJ, et al. J Biol Chem, 2002 May 24. PMID 11907043
    5. The proteome of the presynaptic active zone: from docked synaptic vesicles to adhesion molecules and maxi-channels. Morciano M, et al. J Neurochem, 2009 Feb. PMID 19187093

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables porin activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated monoatomic anion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables voltage-gated monoatomic anion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated monoatomic ion channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in behavioral fear response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within behavioral fear response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in learning IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within learning ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in monoatomic anion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuron-neuron synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within neuron-neuron synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sperm mitochondrial sheath assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sperm mitochondrial sheath assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sperm mitochondrial sheath assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of pore complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    voltage-dependent anion-selective channel protein 3
    Names
    VDAC-3
    mitochondrial voltage dependent anion channel 3
    outer mitochondrial membrane protein porin 3
    rVDAC3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031355.2 → NP_112645.2  voltage-dependent anion-selective channel protein 3

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/Swiss-Prot
      Q6GSZ1, Q9ESR2, Q9JI31, Q9R1Z0, Q9WTU2
      UniProtKB/TrEMBL
      A0A0G2JSR0
      Related
      ENSRNOP00000026197.5, ENSRNOT00000026197.8
      Conserved Domains (1) summary
      cd07306
      Location:5 → 282
      Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      76137489..76153933
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R1Z0.2 GenPept UniProtKB/Swiss-Prot:Q9R1Z0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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