FUM2 FUMARASE 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: FUM2
Official Full Name: FUMARASE 2
Primary source: TAIR:AT5G50950
Locus tag: AT5G50950
See related: Araport:AT5G50950
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: FUMARASE 2; K3K7.11; K3K7_11
Summary: Encodes a fumarase enzyme initially shown to be in the mitochondria through proteomic studies but later shown to be present in the cytosol using an RFP fluorescent protein tag. It appears to be important for the accumulation of fumarate from malate in leaves in the light, and helps to promote nitrogen assimilation under high nitrogen conditions. It does not appear to be necessary for lipid metabolism and seedling growth.
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Genomic context

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See FUM2 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 17

Sequence:: Chromosome: 5; NC_003076.8 (20729431..20733941)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inactivation of cytosolic FUMARASE2 enhances growth and photosynthesis under simultaneous copper and iron deprivation in Arabidopsis.
Title: Inactivation of cytosolic FUMARASE2 enhances growth and photosynthesis under simultaneous copper and iron deprivation in Arabidopsis.
The complex allosteric and redox regulation of the fumarate hydratase and malate dehydratase reactions of Arabidopsis thaliana Fumarase 1 and Fumarase 2 has been reported.
Title: The complex allosteric and redox regulation of the fumarate hydratase and malate dehydratase reactions of Arabidopsis thaliana Fumarase 1 and 2 gives clues for understanding the massive accumulation of fumarate.
Mutants lacking fumarase FUM2 show marked differences in their response to cold, with contrasting responses both in terms of metabolite concentrations and gene expression.
Title: FUM2, a Cytosolic Fumarase, Is Essential for Acclimation to Low Temperature in Arabidopsis thaliana.
FUM2 is required for the accumulation of fumarate in leaves, which is in turn required for rapid nitrogen assimilation and growth on high nitrogen.
Title: Arabidopsis has a cytosolic fumarase required for the massive allocation of photosynthate into fumaric acid and for rapid plant growth on high nitrogen.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001344914.1

Supported by ESTs:

NM_001344915.1

Supported by ESTs:

NM_124474.4

Supported by ESTs:

NM_180835.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables fumarate hydratase activity	IDA Inferred from Direct Assay more info	PubMed
enables fumarate hydratase activity	IEA Inferred from Electronic Annotation more info
enables fumarate hydratase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cold acclimation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fumarate metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within fumarate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in malate metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within nitrate assimilation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein tetramerization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of photosynthesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in cytosol	HDA more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in plastid	HDA more info	PubMed

General protein information

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Preferred Names: FUMARASE 2

NP_001318775.1

FUMARASE 2 (FUM2); FUNCTIONS IN: fumarate hydratase activity, protein binding; INVOLVED IN: nitrate assimilation, response to salt stress, fumarate metabolic process; LOCATED IN: cytosol, mitochondrion; EXPRESSED IN: male gametophyte, guard cell, root, pollen tube; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage; CONTAINS InterPro DOMAIN/s: Fumarate hydratase, class II (InterPro:IPR005677), L-Aspartase-like (InterPro:IPR008948), Fumarate lyase, conserved site (InterPro:IPR020557), Lyase 1, N-terminal (InterPro:IPR022761), Fumarase C, C-terminal (InterPro:IPR018951), Fumarate lyase (InterPro:IPR000362); BEST Arabidopsis thaliana protein match is: fumarase 1 (TAIR:AT2G47510.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NP_199908.1

FUMARASE 2 (FUM2); FUNCTIONS IN: fumarate hydratase activity, protein binding; INVOLVED IN: nitrate assimilation, response to salt stress, fumarate metabolic process; LOCATED IN: cytosol, mitochondrion; EXPRESSED IN: male gametophyte, guard cell, root, pollen tube; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage; CONTAINS InterPro DOMAIN/s: Fumarate hydratase, class II (InterPro:IPR005677), L-Aspartase-like (InterPro:IPR008948), Lyase 1, N-terminal (InterPro:IPR022761), Fumarate lyase, conserved site (InterPro:IPR020557), Fumarase C, C-terminal (InterPro:IPR018951), Fumarate lyase (InterPro:IPR000362); BEST Arabidopsis thaliana protein match is: fumarase 1 (TAIR:AT2G47510.2); Has 20242 Blast hits to 20233 proteins in 2834 species: Archae - 403; Bacteria - 13389; Metazoa - 329; Fungi - 314; Plants - 117; Viruses - 0; Other Eukaryotes - 5690 (source: NCBI BLink).

NP_851166.1

FUMARASE 2 (FUM2); FUNCTIONS IN: fumarate hydratase activity, protein binding; INVOLVED IN: nitrate assimilation, response to salt stress, fumarate metabolic process; LOCATED IN: cytosol, mitochondrion; EXPRESSED IN: male gametophyte, guard cell, root, pollen tube; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage; CONTAINS InterPro DOMAIN/s: Fumarate hydratase, class II (InterPro:IPR005677), L-Aspartase-like (InterPro:IPR008948), Lyase 1, N-terminal (InterPro:IPR022761), Fumarate lyase, conserved site (InterPro:IPR020557), Fumarase C, C-terminal (InterPro:IPR018951), Fumarate lyase (InterPro:IPR000362); BEST Arabidopsis thaliana protein match is: fumarase 1 (TAIR:AT2G47510.2); Has 20040 Blast hits to 20032 proteins in 2805 species: Archae - 403; Bacteria - 13208; Metazoa - 329; Fungi - 298; Plants - 117; Viruses - 0; Other Eukaryotes - 5685 (source: NCBI BLink).