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    FSD3 Fe superoxide dismutase 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832395, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FSD3
    Official Full Name
    Fe superoxide dismutase 3
    Primary source
    TAIR:AT5G23310
    Locus tag
    AT5G23310
    See related
    Araport:AT5G23310
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    Fe superoxide dismutase 3; MKD15.17; MKD15_17; SOD3; superoxide dismutase 3
    Summary
    Fe superoxide dismutase
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    Genomic context

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    See FSD3 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    8
    Sequence:
    Chromosome: 5; NC_003076.8 (7850444..7852534)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene TCP family transcription factor Neighboring gene prefoldin 5 Neighboring gene pyrimidine d Neighboring gene S-isoprenylcysteine O-methyltransferase Neighboring gene Nucleotidylyl transferase superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differential inhibition of Arabidopsis superoxide dismutases by peroxynitrite-mediated tyrosine nitration. Holzmeister C, et al. J Exp Bot, 2015 Feb. PMID 25428993, Free PMC Article
    2. AtECB1/MRL7, a thioredoxin-like fold protein with disulfide reductase activity, regulates chloroplast gene expression and chloroplast biogenesis in Arabidopsis thaliana. Yua QB, et al. Mol Plant, 2014 Jan. PMID 23956074
    3. A heterocomplex of iron superoxide dismutases defends chloroplast nucleoids against oxidative stress and is essential for chloroplast development in Arabidopsis. Myouga F, et al. Plant Cell, 2008 Nov. PMID 18996978, Free PMC Article
    4. PRDA1, a novel chloroplast nucleoid protein, is required for early chloroplast development and is involved in the regulation of plastid gene expression in Arabidopsis. Qiao J, et al. Plant Cell Physiol, 2013 Dec. PMID 24132784
    5. Superoxide dismutase in Arabidopsis: an eclectic enzyme family with disparate regulation and protein localization. Kliebenstein DJ, et al. Plant Physiol, 1998 Oct. PMID 9765550, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Peroxynitrite inhibited mitochondrial manganese superoxide dismutase (SOD1; MSD1), peroxisomal copper/zinc SOD3 (CSD3), and chloroplastic iron SOD3 (FSD3), but no other SODs. MSD1 was inhibited by up to 90% but CSD3 and FSD3 only by a maximum of 30%.
      Title: Differential inhibition of Arabidopsis superoxide dismutases by peroxynitrite-mediated tyrosine nitration.
    2. FSD2 and FSD3 act as ROS scavengers in the maintenance of early chloroplast development by protecting the chloroplast nucleoids from ROS.
      Title: A heterocomplex of iron superoxide dismutases defends chloroplast nucleoids against oxidative stress and is essential for chloroplast development in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_122237.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables superoxide dismutase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within removal of superoxide radicals IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast nucleoid HDA PubMed 
    located_in chloroplast nucleoid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plastid nucleoid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in thylakoid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Fe superoxide dismutase 3
    NP_197722.1
    • Fe superoxide dismutase 3 (FSD3); FUNCTIONS IN: superoxide dismutase activity; INVOLVED IN: removal of superoxide radicals; LOCATED IN: chloroplast, nucleoid; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Manganese/iron superoxide dismutase, N-terminal (InterPro:IPR019831), Manganese/iron superoxide dismutase (InterPro:IPR001189), Manganese/iron superoxide dismutase, C-terminal (InterPro:IPR019832), Manganese/iron superoxide dismutase, binding site (InterPro:IPR019833); BEST Arabidopsis thaliana protein match is: Fe superoxide dismutase 2 (TAIR:AT5G51100.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      7850444..7852534
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_122237.4 → NP_197722.1  Fe superoxide dismutase 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197722.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81240, Q8LCD9, Q9FMX0
      UniProtKB/TrEMBL
      A0A178UFT0, A0A1S6Q8C1, A0A5S9Y6K9
      Conserved Domains (1) summary
      PLN02622
      Location:1 → 263
      PLN02622; iron superoxide dismutase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FMX0.1

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