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    SH3 domain-containing protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829618, updated on 18-Sep-2024

    Summary

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    Official Full Name
    SH3 domain-containing protein
    Primary source
    TAIR:AT4G34660
    Locus tag
    AT4G34660
    See related
    Araport:AT4G34660
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    T4L20.240; T4L20_240
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    Genomic context

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    Location:
    chromosome: 4
    Exon count:
    10
    Sequence:
    Chromosome: 4; NC_003075.7 (16545190..16548494, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene prostatic spermine-binding-like protein Neighboring gene squalene synthase 1 Neighboring gene squalene synthase 2 Neighboring gene Ribosomal protein S3Ae Neighboring gene GATA transcription factor 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Role of the dynamin-related protein 2 family and SH3P2 in clathrin-mediated endocytosis in Arabidopsis thaliana. Gnyliukh N, et al. J Cell Sci, 2024 Apr 15. PMID 38506228, Free PMC Article
    2. Autophagy and its mediated mitochondrial quality control maintain pollen tube growth and male fertility in Arabidopsis. Yan H, et al. Autophagy, 2023 Mar. PMID 35786359, Free PMC Article
    3. Arabidopsis SH3P2 is an ubiquitin-binding protein that functions together with ESCRT-I and the deubiquitylating enzyme AMSH3. Nagel MK, et al. Proc Natl Acad Sci U S A, 2017 Aug 22. PMID 28784794, Free PMC Article
    4. FYVE1 is essential for vacuole biogenesis and intracellular trafficking in Arabidopsis. Kolb C, et al. Plant Physiol, 2015 Apr. PMID 25699591, Free PMC Article
    5. SH3 Domain-Containing Protein 2 Plays a Crucial Role at the Step of Membrane Tubulation during Cell Plate Formation. Ahn G, et al. Plant Cell, 2017 Jun. PMID 28584166, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Role of the dynamin-related protein 2 family and SH3P2 in clathrin-mediated endocytosis in Arabidopsis thaliana.
      Title: Role of the dynamin-related protein 2 family and SH3P2 in clathrin-mediated endocytosis in Arabidopsis thaliana.
    2. Src homology-3 (SH3) domain-containing protein 2 (SH3P2) as a ubiquitin- and ESCRT-I-binding protein that functions in intracellular trafficking.
      Title: Arabidopsis SH3P2 is an ubiquitin-binding protein that functions together with ESCRT-I and the deubiquitylating enzyme AMSH3.
    3. AT4G34660 is a novel regulator of autophagy.AT4G34660, which binds to phosphatidylinositol 3-phosphate and ATG8, regulates autophagosome formation.
      Title: A BAR-domain protein SH3P2, which binds to phosphatidylinositol 3-phosphate and ATG8, regulates autophagosome formation in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001203984.1
    NM_001203985.1
    NM_119632.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-3,4-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-3-phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-4,5-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell plate formation involved in plant-type cell wall biogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within clathrin-dependent endocytosis IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in positive regulation of membrane tubulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in autophagosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell plate IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with clathrin-coated vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in pollen tube IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SH3 domain-containing protein
    NP_001190913.1
    • SH3 domain-containing protein; FUNCTIONS IN: clathrin binding; INVOLVED IN: biological_process unknown; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Src homology-3 domain (InterPro:IPR001452); BEST Arabidopsis thaliana protein match is: SH3 domain-containing protein (TAIR:AT4G18060.1).
    NP_001190914.1
    • SH3 domain-containing protein; FUNCTIONS IN: clathrin binding; INVOLVED IN: biological_process unknown; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Src homology-3 domain (InterPro:IPR001452); BEST Arabidopsis thaliana protein match is: SH3 domain-containing protein (TAIR:AT4G18060.1).
    NP_567969.1
    • SH3 domain-containing protein; CONTAINS InterPro DOMAIN/s: Src homology-3 domain (InterPro:IPR001452); BEST Arabidopsis thaliana protein match is: SH3 domain-containing protein (TAIR:AT4G18060.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      16545190..16548494 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119632.4 → NP_567969.1  SH3 domain-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567969.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4JLF5, F4JLF6, O65689, Q8VWF1
      UniProtKB/TrEMBL
      A0A178V6Q6, A0A5S9XZG9
      Conserved Domains (2) summary
      cd07607
      Location:45 → 254
      BAR_SH3P_plant; The Bin/Amphiphysin/Rvs (BAR) domain of the plant SH3 domain-containing proteins
      cl17036
      Location:303 → 354
      SH3; Src Homology 3 domain superfamily

    2. NM_001203984.1 → NP_001190913.1  SH3 domain-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190913.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8VWF1
      Conserved Domains (2) summary
      cd07607
      Location:22 → 231
      BAR_SH3P_plant; The Bin/Amphiphysin/Rvs (BAR) domain of the plant SH3 domain-containing proteins
      cl17036
      Location:280 → 331
      SH3; Src Homology 3 domain superfamily

    3. NM_001203985.1 → NP_001190914.1  SH3 domain-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190914.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8VWF1
      Conserved Domains (2) summary
      cd07607
      Location:45 → 254
      BAR_SH3P_plant; The Bin/Amphiphysin/Rvs (BAR) domain of the plant SH3 domain-containing proteins
      cl17036
      Location:252 → 303
      SH3; Src Homology 3 domain superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VWF1.1

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