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    CAD5 cinnamyl alcohol dehydrogenase 5 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829572, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CAD5
    Official Full Name
    cinnamyl alcohol dehydrogenase 5
    Primary source
    TAIR:AT4G34230
    Locus tag
    AT4G34230
    See related
    Araport:AT4G34230
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATCAD5; CAD-5; cinnamyl alcohol dehydrogenase 5; F10M10.11
    Summary
    Encodes a catalytically active cinnamyl alcohol dehydrogenase which uses p-coumaryl aldehyde as a preferred substrate. It can also use sinapyl, caffeyl, coniferyl and d-hydroxyconiferyl aldehydes as substrates.
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    Genomic context

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    See CAD5 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    5
    Sequence:
    Chromosome: 4; NC_003075.7 (16386631..16388940, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Leucine-rich repeat protein kinase family protein Neighboring gene ncRNA Neighboring gene aldehyde dehydrogenase 3I1 Neighboring gene 3-ketoacyl-CoA synthase 16

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manipulation of Guaiacyl and Syringyl Monomer Biosynthesis in an Arabidopsis Cinnamyl Alcohol Dehydrogenase Mutant Results in Atypical Lignin Biosynthesis and Modified Cell Wall Structure. Anderson NA, et al. Plant Cell, 2015 Aug. PMID 26265762, Free PMC Article
    2. Root and vascular tissue-specific expression of glycine-rich protein AtGRP9 and its interaction with AtCAD5, a cinnamyl alcohol dehydrogenase, in Arabidopsis thaliana. Chen AP, et al. J Plant Res, 2007 Mar. PMID 17287892
    3. Crystal structures and catalytic mechanism of the Arabidopsis cinnamyl alcohol dehydrogenases AtCAD5 and AtCAD4. Youn B, et al. Org Biomol Chem, 2006 May 7. PMID 16633561
    4. CINNAMYL ALCOHOL DEHYDROGENASE-C and -D are the primary genes involved in lignin biosynthesis in the floral stem of Arabidopsis. Sibout R, et al. Plant Cell, 2005 Jul. PMID 15937231, Free PMC Article
    5. Expression pattern of two paralogs encoding cinnamyl alcohol dehydrogenases in Arabidopsis. Isolation and characterization of the corresponding mutants. Sibout R, et al. Plant Physiol, 2003 Jun. PMID 12805615, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that disruption of the genes encoding both cinnamyl alcohol dehydrogenases CADC (At3g19450) and CADD (At4g34230) results in the atypical incorporation of hydroxycinnamaldehydes into lignin.
      Title: Manipulation of Guaiacyl and Syringyl Monomer Biosynthesis in an Arabidopsis Cinnamyl Alcohol Dehydrogenase Mutant Results in Atypical Lignin Biosynthesis and Modified Cell Wall Structure.
    2. Repressing both the CAD and the CCR activities results in sterility and dwarfism.
      Title: The simultaneous repression of CCR and CAD, two enzymes of the lignin biosynthetic pathway, results in sterility and dwarfism in Arabidopsis thaliana.
    3. These results suggest that AtGRP9 may be involved in lignin synthesis in response to salt stress as a result of its interaction with AtCAD5 in A. thaliana.
      Title: Root and vascular tissue-specific expression of glycine-rich protein AtGRP9 and its interaction with AtCAD5, a cinnamyl alcohol dehydrogenase, in Arabidopsis thaliana.
    4. determined the crystal structures of AtCAD5 in the apo-form and as a binary complex with NADP+, respectively, and modeled that of AtCAD4. The substrate-binding pockets of both AtCAD5 and AtCAD4 were also examined.
      Title: Crystal structures and catalytic mechanism of the Arabidopsis cinnamyl alcohol dehydrogenases AtCAD5 and AtCAD4.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001036711.1
    NM_119587.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables cinnamyl-alcohol dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cinnamyl-alcohol dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cinnamyl-alcohol dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within lignin biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within lignin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lignin biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    cinnamyl alcohol dehydrogenase 5
    NP_001031788.1
    • cinnamyl alcohol dehydrogenase 5 (CAD5); CONTAINS InterPro DOMAIN/s: GroES-like (InterPro:IPR011032), Alcohol dehydrogenase GroES-like (InterPro:IPR013154), Alcohol dehydrogenase, zinc-containing, conserved site (InterPro:IPR002328), Alcohol dehydrogenase, C-terminal (InterPro:IPR013149), Alcohol dehydrogenase superfamily, zinc-containing (InterPro:IPR002085); BEST Arabidopsis thaliana protein match is: GroES-like zinc-binding alcohol dehydrogenase family protein (TAIR:AT3G19450.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_195149.1
    • cinnamyl alcohol dehydrogenase 5 (CAD5); CONTAINS InterPro DOMAIN/s: GroES-like (InterPro:IPR011032), Polyketide synthase, enoylreductase (InterPro:IPR020843), Alcohol dehydrogenase GroES-like (InterPro:IPR013154), Alcohol dehydrogenase, zinc-containing, conserved site (InterPro:IPR002328), Alcohol dehydrogenase, C-terminal (InterPro:IPR013149), Alcohol dehydrogenase superfamily, zinc-containing (InterPro:IPR002085); BEST Arabidopsis thaliana protein match is: GroES-like zinc-binding alcohol dehydrogenase family protein (TAIR:AT3G19450.1); Has 41203 Blast hits to 41171 proteins in 3032 species: Archae - 764; Bacteria - 27799; Metazoa - 1384; Fungi - 3121; Plants - 2810; Viruses - 3; Other Eukaryotes - 5322 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      16386631..16388940 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119587.4 → NP_195149.1  cinnamyl alcohol dehydrogenase 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195149.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O49482, Q53ZN0
      UniProtKB/TrEMBL
      A0A178V3B0, A0A5S9XYH8
      Conserved Domains (1) summary
      PLN02514
      Location:1 → 357
      PLN02514; cinnamyl-alcohol dehydrogenase

    2. NM_001036711.1 → NP_001031788.1  cinnamyl alcohol dehydrogenase 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031788.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4JKM2
      Conserved Domains (2) summary
      PLN02514
      Location:1 → 357
      PLN02514; cinnamyl-alcohol dehydrogenase
      cd05283
      Location:11 → 349
      CAD1; Cinnamyl alcohol dehydrogenases (CAD)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O49482.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
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