PAB2 poly(A) binding protein 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Go to the top of the page Help

Official Symbol: PAB2
Official Full Name: poly(A) binding protein 2
Primary source: TAIR:AT4G34110
Locus tag: AT4G34110
See related: Araport:AT4G34110
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS POLY(A) BINDING 2; ATPAB2; F28A23.130; F28A23_130; PABP2; poly(A) binding protein 2; POLY(A) BINDING PROTEIN 2; POLY(A)-BINDING PROTEIN 2
Summary: Putative poly-A binding protein. Member of a gene family .Expressed in stele and root meristem and post-fertilization ovules.Member of the class II family of PABP proteins.
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See PAB2 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 9

Sequence:: Chromosome: 4; NC_003075.7 (16336291..16340314)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Poly(A) Binding Protein binds to uridylated oligo(A) tails and determines the length of U-extensions added by URT1.
Title: Uridylation and PABP Cooperate to Repair mRNA Deadenylated Ends in Arabidopsis.
Thus, Hsc70-3 and PABP2 are potentially integral components of the replicase complex and could have important roles to play in the regulation of potyviral RdRp functions.
Title: Heat shock 70 protein interaction with Turnip mosaic virus RNA-dependent RNA polymerase within virus-induced membrane vesicles.
PAB2 was partially retargeted to the nucleolus in the presence of TuMV VPg-Pro. In addition, the membrane association of PAB2 during TuMV infection resulted from the internalization of the host protein in 6K-VPg-Pro-induced vesicles.
Title: The poly(A) binding protein is internalized in virus-induced vesicles or redistributed to the nucleolus during turnip mosaic virus infection.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

NM_119572.7

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables mRNA binding	HDA more info	PubMed
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables translation initiation factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in mRNA stabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of nuclear-transcribed mRNA poly(A) tail shortening	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of translational initiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within translational initiation	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	HDA more info	PubMed
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: poly(A) binding protein 2

NP_195137.5

poly(A) binding protein 2 (PAB2); FUNCTIONS IN: RNA binding, translation initiation factor activity; INVOLVED IN: response to salt stress, translational initiation; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 17 growth stages; CONTAINS InterPro DOMAIN/s: Polyadenylate-binding protein/Hyperplastic disc protein (InterPro:IPR002004), RNA recognition motif, RNP-1 (InterPro:IPR000504), Polyadenylate binding protein, human types 1, 2, 3, 4 (InterPro:IPR006515), Paraneoplastic encephalomyelitis antigen (InterPro:IPR002343), Nucleotide-binding, alpha-beta plait (InterPro:IPR012677); BEST Arabidopsis thaliana protein match is: poly(A) binding protein 8 (TAIR:AT1G49760.2); Has 987994 Blast hits to 947802 proteins in 35008 species: Archae - 20430; Bacteria - 568582; Metazoa - 213912; Fungi - 30250; Plants - 62241; Viruses - 64851; Other Eukaryotes - 27728 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

16336291..16340314

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_119572.7 → NP_195137.5 poly(A) binding protein 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_195137.5

Status: REVIEWED

UniProtKB/Swiss-Prot

P42731, Q8RXR5

UniProtKB/TrEMBL

A0A178UWB3, A0A5S9XYF9

Conserved Domains (1) summary

TIGR01628
Location:37 → 612

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family