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    DBR1 debranching enzyme 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829305, updated on 11-Oct-2024

    Summary

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    Official Symbol
    DBR1
    Official Full Name
    debranching enzyme 1
    Primary source
    TAIR:AT4G31770
    Locus tag
    AT4G31770
    See related
    Araport:AT4G31770
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA DEBRANCHING ENZYME 1; ATDBR1; debranching enzyme 1; F28M20.40; F28M20_40
    Summary
    Encodes a RNA lariat debranching enzyme required for embryogenesis.
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    Genomic context

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    See DBR1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    9
    Sequence:
    Chromosome: 4; NC_003075.7 (15370061..15372942, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Sec1/munc18-like (SM) proteins superfamily Neighboring gene HOPW1-1-interacting 2 Neighboring gene peroxidase superfamily protein Neighboring gene monogalactosyl diacylglycerol synthase 1 Neighboring gene Tetrapyrrole (Corrin/Porphyrin) Methylase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sequestration of DBR1 to stress granules promotes lariat intronic RNAs accumulation for heat-stress tolerance. Wu C, et al. Nat Commun, 2024 Sep 3. PMID 39227617, Free PMC Article
    2. An Arabidopsis RNA lariat debranching enzyme is essential for embryogenesis. Wang H, et al. J Biol Chem, 2004 Jan 9. PMID 14570879
    3. Intron Lariat RNA Inhibits MicroRNA Biogenesis by Sequestering the Dicing Complex in Arabidopsis. Li Z, et al. PLoS Genet, 2016 Nov. PMID 27870853, Free PMC Article
    4. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    General gene information

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    NM_001342112.1
    NM_119326.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables RNA lariat debranching enzyme activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    debranching enzyme 1
    NP_567881.1
    • debranching enzyme 1 (DBR1); CONTAINS InterPro DOMAIN/s: Metallophosphoesterase (InterPro:IPR004843), Lariat debranching enzyme, C-terminal (InterPro:IPR007708); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      15370061..15372942 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119326.4 → NP_567881.1  debranching enzyme 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567881.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81771, Q94K01
      UniProtKB/TrEMBL
      A0A178V4L6, A0A384KTP8, A0A5S9XXQ3, A0A654FUL9, Q0D241
      Conserved Domains (2) summary
      cd00844
      Location:3 → 259
      MPP_Dbr1_N; Dbr1 RNA lariat debranching enzyme, N-terminal metallophosphatase domain
      pfam05011
      Location:241 → 352
      DBR1; Lariat debranching enzyme, C-terminal domain

    2. NM_001342112.1 → NP_001328612.1  debranching enzyme 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B568, A0A5S9XXQ3, A0A654FUL9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94K01.1

    Gene LinkOut

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