SIP3 SOS3-interacting protein 3 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: SIP3
Official Full Name: SOS3-interacting protein 3
Primary source: TAIR:AT4G30960
Locus tag: AT4G30960
See related: Araport:AT4G30960
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATCIPK6; CBL-INTERACTING PROTEIN KINASE 6; CIPK6; F6I18.130; F6I18_130; SNF1-RELATED PROTEIN KINASE 3.14; SNRK3.14; SOS3-interacting protein 3
Summary: Encodes CBL-interacting protein kinase 6 (CIPK6). Required for development and salt tolerance.
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Genomic context

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See SIP3 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 1

Sequence:: Chromosome: 4; NC_003075.7 (15067028..15069183)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A calcium-regulated protein kinase Calcineurin B-like protein (CBL)-interacting protein kinase 6 (CIPK6) functions as a negative regulator of immunity against the bacterial pathogen Pseudomonas syringae in Arabidopsis thaliana.
Title: CBL-interacting protein kinase 6 negatively regulates immune response to Pseudomonas syringae in Arabidopsis.
Arabidopsis CBL-interacting protein kinase (CIPK6) is involved in plant response to salt/osmotic stress and abscisic acid.
Title: Arabidopsis CBL-interacting protein kinase (CIPK6) is involved in plant response to salt/osmotic stress and ABA.
CBL4 together with the interacting protein kinase CIPK6 modulates the activity and plasma membrane targeting of the K(+) channel AKT2.
Title: Calcium-dependent modulation and plasma membrane targeting of the AKT2 potassium channel by the CBL4/CIPK6 calcium sensor/protein kinase complex.
These findings provide further insights into the signaling network consisting of CBL-CIPK-PP2C interactions in the activation of the AKT1 channel.
Title: Mechanistic analysis of AKT1 regulation by the CBL-CIPK-PP2CA interactions.
Transgenic seedlings expressing CIPK3 displayed increased root length, overall root branching and hypersensitivity to auxin. Mutation caused defects in seedling development and auxin transport.
Title: CIPK6, a CBL-interacting protein kinase is required for development and salt tolerance in plants.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Miscellaneous features

Loc: 15067184-15067282 AT4G30960.uORF1

NM_119244.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within basipetal auxin transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hyperosmotic salinity response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within multicellular organism development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to calcium ion	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to salt stress	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to water deprivation	IEP Inferred from Expression Pattern more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: SOS3-interacting protein 3

NP_194825.1

SOS3-interacting protein 3 (SIP3); FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: in 6 processes; LOCATED IN: cellular_component unknown; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), NAF/FISL domain (InterPro:IPR018451), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), NAF domain (InterPro:IPR004041), CBL-interacting protein kinase (InterPro:IPR020660), Protein kinase, catalytic domain (InterPro:IPR000719), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636); BEST Arabidopsis thaliana protein match is: CBL-interacting protein kinase 20 (TAIR:AT5G45820.1); Has 129448 Blast hits to 127362 proteins in 4509 species: Archae - 159; Bacteria - 15496; Metazoa - 47121; Fungi - 13315; Plants - 31167; Viruses - 523; Other Eukaryotes - 21667 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

15067028..15069183

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_119244.3 → NP_194825.1 SOS3-interacting protein 3 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_194825.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O65554

UniProtKB/TrEMBL

A0A178UTV2, A0A5S9XZM8, A0A7G2F557

Conserved Domains (2) summary

cd12195
Location:316 → 432

CIPK_C; C-terminal regulatory domain of Calcineurin B-Like (CBL)-interacting protein kinases

cl21453
Location:23 → 277

PKc_like; Protein Kinases, catalytic domain