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    SHD Chaperone protein htpG family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828520, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SHD
    Official Full Name
    Chaperone protein htpG family protein
    Primary source
    TAIR:AT4G24190
    Locus tag
    AT4G24190
    See related
    Araport:AT4G24190
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtHsp90-7; AtHsp90.7; HEAT SHOCK PROTEIN 90-7; HEAT SHOCK PROTEIN 90.7; HSP90.7; SHEPHERD; T22A6.20; T22A6_20
    Summary
    encodes an ortholog of GRP94, an ER-resident HSP90-like protein and is involved in regulation of meristem size and organization. Single and double mutant analyses suggest that SHD may be required for the correct folding and/or complex formation of CLV proteins. Lines carrying recessive mutations in this locus exhibits expanded shoot meristems, disorganized root meristems, and defective pollen tube elongation. Transcript is detected in all tissues examined and is not induced by heat. Endoplasmin supports the protein secretory pathway and has a role in proliferating tissues.
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    Genomic context

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    See SHD in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    15
    Sequence:
    Chromosome: 4; NC_003075.7 (12551552..12556058, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene kinesin-like protein Neighboring gene THAUMATIN-LIKE PROTEIN 1 Neighboring gene Transcription elongation factor (TFIIS) family protein Neighboring gene RING/U-box superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SHEPHERD is the Arabidopsis GRP94 responsible for the formation of functional CLAVATA proteins. Ishiguro S, et al. EMBO J, 2002 Mar 1. PMID 11867518, Free PMC Article
    2. Plant endoplasmin supports the protein secretory pathway and has a role in proliferating tissues. Klein EM, et al. Plant J, 2006 Dec. PMID 17059403
    3. Overexpression of AtHsp90.2, AtHsp90.5 and AtHsp90.7 in Arabidopsis thaliana enhances plant sensitivity to salt and drought stresses. Song H, et al. Planta, 2009 Mar. PMID 19148673
    4. A highly charged region in the middle domain of plant endoplasmic reticulum (ER)-localized heat-shock protein 90 is required for resistance to tunicamycin or high calcium-induced ER stresses. Chong LP, et al. J Exp Bot, 2015 Jan. PMID 25297550, Free PMC Article
    5. Expression of five AtHsp90 genes in Saccharomyces cerevisiae reveals functional differences of AtHsp90s under abiotic stresses. Song H, et al. J Plant Physiol, 2010 Sep 15. PMID 20493581

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Seedlings expressing HSP90.7(Delta22) had enhanced sensitivity to ER stress induced by tunicamycin or high concentration of calcium. Its general chaperone activity in preventing the model protein from heat-induced aggregation was not significantly affected.
      Title: A highly charged region in the middle domain of plant endoplasmic reticulum (ER)-localized heat-shock protein 90 is required for resistance to tunicamycin or high calcium-induced ER stresses.
    2. Results show that the induction expression of ABA-responsive genes under salt and drought stress was delayed by constitutive overexpression of cytosolic AtHsp90.2, but was hardly affected by that of organellar AtHsp90.5 and AtHsp90.7.
      Title: Overexpression of AtHsp90.2, AtHsp90.5 and AtHsp90.7 in Arabidopsis thaliana enhances plant sensitivity to salt and drought stresses.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_118552.4
    NM_202877.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein secretion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of meristem growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of meristem structural organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to water deprivation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    NOT located_in Golgi apparatus RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in plasma membrane HDA PubMed 
    located_in plasmodesma HDA PubMed 
    located_in secretory vesicle HDA PubMed 

    General protein information

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    Preferred Names
    Chaperone protein htpG family protein
    NP_194150.1
    • SHEPHERD (SHD); FUNCTIONS IN: unfolded protein binding, ATP binding; INVOLVED IN: in 8 processes; LOCATED IN: in 7 components; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Chaperone protein htpG (InterPro:IPR001404), Heat shock protein Hsp90, C-terminal (InterPro:IPR020576), Heat shock protein Hsp90, N-terminal (InterPro:IPR020575), Molecular chaperone, heat shock protein, endoplasmin (InterPro:IPR015566), ATPase-like, ATP-binding domain (InterPro:IPR003594), Heat shock protein Hsp90, conserved site (InterPro:IPR019805), Ribosomal protein S5 domain 2-type fold (InterPro:IPR020568); BEST Arabidopsis thaliana protein match is: heat shock protein 90.1 (TAIR:AT5G52640.1); Has 10659 Blast hits to 10182 proteins in 2496 species: Archae - 7; Bacteria - 3605; Metazoa - 2791; Fungi - 470; Plants - 491; Viruses - 10; Other Eukaryotes - 3285 (source: NCBI BLink).
    NP_974606.1
    • SHEPHERD (SHD); FUNCTIONS IN: unfolded protein binding, ATP binding; INVOLVED IN: in 8 processes; LOCATED IN: in 6 components; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Chaperone protein htpG (InterPro:IPR001404), Heat shock protein Hsp90, C-terminal (InterPro:IPR020576), Heat shock protein Hsp90, N-terminal (InterPro:IPR020575), Molecular chaperone, heat shock protein, endoplasmin (InterPro:IPR015566), ATPase-like, ATP-binding domain (InterPro:IPR003594), Heat shock protein Hsp90, conserved site (InterPro:IPR019805), Ribosomal protein S5 domain 2-type fold (InterPro:IPR020568); BEST Arabidopsis thaliana protein match is: heat shock protein 90.1 (TAIR:AT5G52640.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      12551552..12556058 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118552.4 → NP_194150.1  Chaperone protein htpG family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194150.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22972, Q56Y38, Q8VY71, Q9STX5
      UniProtKB/TrEMBL
      A0A654FS92, Q8RVG8
      Conserved Domains (3) summary
      PRK05218
      Location:74 → 763
      PRK05218; heat shock protein 90; Provisional
      pfam00183
      Location:258 → 775
      HSP90; Hsp90 protein
      pfam02518
      Location:104 → 253
      HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

    2. NM_202877.1 → NP_974606.1  Chaperone protein htpG family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974606.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654FS92, F4JQ55, Q8RVG8
      Conserved Domains (3) summary
      PRK05218
      Location:74 → 763
      PRK05218; heat shock protein 90; Provisional
      pfam00183
      Location:258 → 775
      HSP90; Hsp90 protein
      pfam02518
      Location:104 → 253
      HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9STX5.1

    Gene LinkOut

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