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    DIR6 Disease resistance-responsive (dirigent-like protein) family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828469, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DIR6
    Official Full Name
    Disease resistance-responsive (dirigent-like protein) family protein
    Primary source
    TAIR:AT4G23690
    Locus tag
    AT4G23690
    See related
    Araport:AT4G23690
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    Arabidopsis thaliana dirigent protein 6; AtDIR6; dirigent protein 6; F9D16.160; F9D16_160
    Summary
    Encodes a homodimeric all-beta dirigent protein in the superfamily of calycins. Dirigent proteins impart stereoselectivity on the phenoxy radical coupling reaction yielding optically active lignans from two molecules of coniferyl alcohol.
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    Genomic context

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    See DIR6 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    1
    Sequence:
    Chromosome: 4; NC_003075.7 (12338829..12339967, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Polyketide cyclase/dehydrase and lipid transport superfamily protein Neighboring gene Polyketide cyclase/dehydrase and lipid transport superfamily protein Neighboring gene cation/H+ exchanger 17 Neighboring gene vacuolar ATP synthase subunit G2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Optimized expression of the dirigent protein AtDIR6 in Pichia pastoris and impact of glycosylation on protein structure and function. Kazenwadel C, et al. Appl Microbiol Biotechnol, 2013 Aug. PMID 23188459
    2. A model of dirigent proteins derived from structural and functional similarities with allene oxide cyclase and lipocalins. Pickel B, et al. FEBS J, 2012 Jun. PMID 22443713
    3. An enantiocomplementary dirigent protein for the enantioselective laccase-catalyzed oxidative coupling of phenols. Pickel B, et al. Angew Chem Int Ed Engl, 2010. PMID 19946920
    4. Opposite stereoselectivities of dirigent proteins in Arabidopsis and schizandra species. Kim KW, et al. J Biol Chem, 2012 Oct 5. PMID 22854967, Free PMC Article
    5. Dirigent Protein Mode of Action Revealed by the Crystal Structure of AtDIR6. Gasper R, et al. Plant Physiol, 2016 Dec. PMID 27756822, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    NM_118500.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables guiding stereospecific synthesis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within (-)-pinoresinol biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in (-)-pinoresinol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Disease resistance-responsive (dirigent-like protein) family protein
    NP_194100.1
    • Disease resistance-responsive (dirigent-like protein) family protein; FUNCTIONS IN: molecular_function unknown; INVOLVED IN: lignan biosynthetic process, defense response; LOCATED IN: endomembrane system; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Plant disease resistance response protein (InterPro:IPR004265); BEST Arabidopsis thaliana protein match is: Disease resistance-responsive (dirigent-like protein) family protein (TAIR:AT1G64160.1); Has 772 Blast hits to 771 proteins in 42 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 772; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      12338829..12339967 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118500.3 → NP_194100.1  Disease resistance-responsive (dirigent-like protein) family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194100.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SUQ8
      UniProtKB/TrEMBL
      A0A178UWA1, A0A5S9XVU9, A0A654FS52
      Conserved Domains (1) summary
      pfam03018
      Location:41 → 183
      Dirigent; Dirigent-like protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SUQ8.1

    Gene LinkOut

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