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    GRH1 GRR1-like protein 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828045, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GRH1
    Official Full Name
    GRR1-like protein 1
    Primary source
    TAIR:AT4G03190
    Locus tag
    AT4G03190
    See related
    Araport:AT4G03190
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    A. THALIANA GERMIN-LIKE PROTEIN 1; AFB1; ATFBL18; ATGER1; ATGRH1; AUXIN SIGNALING F BOX PROTEIN 1; F4C21.11; F4C21_11; GRR1-like protein 1
    Summary
    Encodes an F box protein belonging to the TIR1 subfamily. This protein forms SCF complexes with ASK1 and CUL1 and interacts with Aux/IAA proteins in an auxin-dependent manner. It also has sequence similarity to the yeast protein GRR1, which is involved in glucose repression.
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    Genomic context

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    See GRH1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    3
    Sequence:
    Chromosome: 4; NC_003075.7 (1404887..1407402, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Protein kinase superfamily protein Neighboring gene rRNA-processing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene catalytics Neighboring gene Coproporphyrinogen III oxidase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The AFB1 auxin receptor controls the cytoplasmic auxin response pathway in Arabidopsis thaliana. Dubey SM, et al. Mol Plant, 2023 Jul 3. PMID 37391902, Free PMC Article
    2. Cloning by pathway activation in yeast: identification of an Arabidopsis thaliana F-box protein that can turn on glucose repression. Thelander M, et al. Plant Mol Biol, 2002 May. PMID 12008900
    3. Complex regulation of the TIR1/AFB family of auxin receptors. Parry G, et al. Proc Natl Acad Sci U S A, 2009 Dec 29. PMID 20018756, Free PMC Article
    4. The F-box protein TIR1 is an auxin receptor. Dharmasiri N, et al. Nature, 2005 May 26. PMID 15917797
    5. Auxin regulates Arabidopsis anther dehiscence, pollen maturation, and filament elongation. Cecchetti V, et al. Plant Cell, 2008 Jul. PMID 18628351, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    NM_116555.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables auxin binding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables auxin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables inositol hexakisphosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in auxin-activated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within carbon catabolite repression of transcription by glucose TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within developmental growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen maturation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to auxin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within stamen development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    part_of nuclear SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GRR1-like protein 1
    NP_567255.1
    • GRR1-like protein 1 (GRH1); CONTAINS InterPro DOMAIN/s: F-box domain, cyclin-like (InterPro:IPR001810); BEST Arabidopsis thaliana protein match is: F-box/RNI-like superfamily protein (TAIR:AT3G62980.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      1404887..1407402 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_116555.4 → NP_567255.1  GRR1-like protein 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567255.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94AU0, Q9C5Y7, Q9ZR12
      UniProtKB/TrEMBL
      A0A178UXT3, A0A5S9XPG5
      Conserved Domains (4) summary
      cd09293
      Location:280 → 488
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:287 → 311
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam18511
      Location:4 → 43
      F-box_5
      pfam18791
      Location:62 → 108
      Transp_inhibit; Transport inhibitor response 1 protein domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZR12.1

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