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    KEA2 K+ efflux antiporter 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 825834, updated on 18-Sep-2024

    Summary

    Official Symbol
    KEA2
    Official Full Name
    K+ efflux antiporter 2
    Primary source
    TAIR:AT4G00630
    Locus tag
    AT4G00630
    See related
    Araport:AT4G00630
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATKEA2; F6N23.15; F6N23_15; K+ efflux antiporter 2
    Summary
    Encodes a K(+)/H(+) antiporter that modulates monovalent cation and pH homeostasis in plant chloroplasts or plastids.
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    Genomic context

    See KEA2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    20
    Sequence:
    Chromosome: 4; NC_003075.7 (261246..268097, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Amino acid dehydrogenase family protein Neighboring gene DNA-binding storekeeper protein-related transcriptional regulator Neighboring gene Amino acid dehydrogenase family protein Neighboring gene FRIGIDA-like protein Neighboring gene ncRNA Neighboring gene Fe superoxide dismutase Neighboring gene ncRNA

    Bibliography

    General gene information

    NM_001203716.1

    Gene Ontology Provided by TAIR

    Process Evidence Code Pubs
    acts_upstream_of_positive_effect calcium-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within chloroplast organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within plastid gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within plastid rRNA transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within potassium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in potassium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within_positive_effect primary root development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within proton transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within_positive_effect reactive nitrogen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_positive_effect regulation of cellular hyperosmotic salinity response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of pH IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of photosynthesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of photosynthesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of response to water deprivation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of seedling development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within_positive_effect response to abscisic acid IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to absence of light IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within_positive_effect response to sucrose IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    K+ efflux antiporter 2
    NP_001190645.1
    • K+ efflux antiporter 2 (KEA2); FUNCTIONS IN: potassium:hydrogen antiporter activity, potassium ion transmembrane transporter activity; INVOLVED IN: potassium ion transport, cation transport, metabolic process, transmembrane transport; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: K+/H+ exchanger (InterPro:IPR004771), Cation/H+ exchanger (InterPro:IPR006153), NAD(P)-binding domain (InterPro:IPR016040), Regulator of K+ conductance, N-terminal (InterPro:IPR003148); BEST Arabidopsis thaliana protein match is: K+ efflux antiporter 1 (TAIR:AT1G01790.1).
    NP_191972.6
    • K+ efflux antiporter 2 (KEA2); FUNCTIONS IN: potassium:hydrogen antiporter activity, potassium ion transmembrane transporter activity; INVOLVED IN: potassium ion transport, cation transport, metabolic process, transmembrane transport; LOCATED IN: chloroplast, membrane, chloroplast envelope; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Cation/H+ exchanger (InterPro:IPR006153), K+/H+ exchanger (InterPro:IPR004771), NAD(P)-binding domain (InterPro:IPR016040), Regulator of K+ conductance, N-terminal (InterPro:IPR003148); BEST Arabidopsis thaliana protein match is: K+ efflux antiporter 1 (TAIR:AT1G01790.1); Has 34304 Blast hits to 27699 proteins in 2887 species: Archae - 928; Bacteria - 15112; Metazoa - 9897; Fungi - 1524; Plants - 1371; Viruses - 95; Other Eukaryotes - 5377 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      261246..268097 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_116288.7NP_191972.6  K+ efflux antiporter 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191972.6

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65272, O65273
      UniProtKB/TrEMBL
      A0A5S9XQF2, A0A654FKN7
      Conserved Domains (2) summary
      PRK02224
      Location:118388
      PRK02224; DNA double-strand break repair Rad50 ATPase
      PRK03562
      Location:5781098
      PRK03562; glutathione-regulated potassium-efflux system protein KefC; Provisional
    2. NM_001203716.1NP_001190645.1  K+ efflux antiporter 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190645.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9XQF2, F4JHE9
      Conserved Domains (7) summary
      COG1226
      Location:9811153
      Kch; Voltage-gated potassium channel Kch [Inorganic ion transport and metabolism]
      TIGR00932
      Location:578867
      2a37; transporter, monovalent cation:proton antiporter-2 (CPA2) family
      pfam00769
      Location:243446
      ERM; Ezrin/radixin/moesin family
      pfam02254
      Location:9891102
      TrkA_N; TrkA-N domain
      pfam05145
      Location:596957
      AmoA; Putative ammonia monooxygenase
      pfam16731
      Location:143304
      GARP; Glutamic acid/alanine-rich protein of Trypanosoma
      cl02488
      Location:115323
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...