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    ERD (early-responsive to dehydration stress) family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 825754, updated on 18-Sep-2024

    Summary

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    Official Full Name
    ERD (early-responsive to dehydration stress) family protein
    Primary source
    TAIR:AT4G04340
    Locus tag
    AT4G04340
    See related
    Araport:AT4G04340
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    induced Ca2+ increase 1 (osca1); osca1; reduced hyperosmolality; T19B17.6; T19B17_6
    Summary
    Encodes a plasma membrane localized hyperosmolality gated calcium channel that is expressed in guard cells and roots.
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    Genomic context

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    Location:
    chromosome: 4
    Exon count:
    12
    Sequence:
    Chromosome: 4; NC_003075.7 (2122507..2126910)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene malonyl-CoA decarboxylase family protein Neighboring gene Chaperonin-like RbcX protein Neighboring gene tRNA synthetase class I (I, L, M and V) family protein Neighboring gene transmembrane protein, putative (DUF1068) Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Osmotic stress alters circadian cytosolic Ca(2+) oscillations and OSCA1 is required in circadian gated stress adaptation. Zhang S, et al. Plant Signal Behav, 2020 Dec 1. PMID 33100175, Free PMC Article
    2. Cryo-EM structure of the mechanically activated ion channel OSCA1.2. Jojoa-Cruz S, et al. Elife, 2018 Nov 1. PMID 30382939, Free PMC Article
    3. OSCA1 mediates osmotic-stress-evoked Ca2+ increases vital for osmosensing in Arabidopsis. Yuan F, et al. Nature, 2014 Oct 16. PMID 25162526
    4. The calcium-permeable channel OSCA1.3 regulates plant stomatal immunity. Thor K, et al. Nature, 2020 Sep. PMID 32846426, Free PMC Article
    5. Large-scale analysis of in vivo phosphorylated membrane proteins by immobilized metal ion affinity chromatography and mass spectrometry. Nühse TS, et al. Mol Cell Proteomics, 2003 Nov. PMID 14506206

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Osmotic stress alters circadian cytosolic Ca(2+) oscillations and OSCA1 is required in circadian gated stress adaptation.
      Title: Osmotic stress alters circadian cytosolic Ca(2+) oscillations and OSCA1 is required in circadian gated stress adaptation.
    2. The calcium-permeable channel OSCA1.3 regulates plant stomatal immunity.
      Title: The calcium-permeable channel OSCA1.3 regulates plant stomatal immunity.
    3. Molecular dynamics simulations reveal membrane interactions, suggesting the role of lipids in OSCA1.2 gating.
      Title: Cryo-EM structure of the mechanically activated ion channel OSCA1.2.
    4. OSCA1 is a previously unknown plasma membrane protein that forms hyperosmolality-gated calcium-permeable channels, revealing that OSCA1 may be an osmosensor; OSCA1 represents a channel responsible for [Ca(2+)]i increases induced by a stimulus in plants. [OSCA1]
      Title: OSCA1 mediates osmotic-stress-evoked Ca2+ increases vital for osmosensing in Arabidopsis.
    Submit: New GeneRIF Correction

    General gene information

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    NM_116672.4
    NM_178965.2
    NM_178966.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables calcium-activated cation channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables monoatomic cation channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular hyperosmotic response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular hyperosmotic response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein tetramerization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of calcium ion import IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    ERD (early-responsive to dehydration stress) family protein
    NP_192343.1
    • ERD (early-responsive to dehydration stress) family protein; LOCATED IN: plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein of unknown function DUF221 (InterPro:IPR003864); BEST Arabidopsis thaliana protein match is: ERD (early-responsive to dehydration stress) family protein (TAIR:AT4G22120.6); Has 1468 Blast hits to 1288 proteins in 193 species: Archae - 0; Bacteria - 4; Metazoa - 185; Fungi - 720; Plants - 437; Viruses - 0; Other Eukaryotes - 122 (source: NCBI BLink).
    NP_849296.1
    • ERD (early-responsive to dehydration stress) family protein; LOCATED IN: plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein of unknown function DUF221 (InterPro:IPR003864); BEST Arabidopsis thaliana protein match is: ERD (early-responsive to dehydration stress) family protein (TAIR:AT4G22120.6); Has 1469 Blast hits to 1289 proteins in 193 species: Archae - 0; Bacteria - 4; Metazoa - 185; Fungi - 721; Plants - 437; Viruses - 0; Other Eukaryotes - 122 (source: NCBI BLink).
    NP_849297.1
    • ERD (early-responsive to dehydration stress) family protein; LOCATED IN: plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein of unknown function DUF221 (InterPro:IPR003864); BEST Arabidopsis thaliana protein match is: ERD (early-responsive to dehydration stress) family protein (TAIR:AT4G22120.6); Has 1468 Blast hits to 1288 proteins in 193 species: Archae - 0; Bacteria - 4; Metazoa - 185; Fungi - 720; Plants - 437; Viruses - 0; Other Eukaryotes - 122 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      2122507..2126910
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_116672.4 → NP_192343.1  ERD (early-responsive to dehydration stress) family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_192343.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A097NUN6, Q93ZR7, Q9XEA1
      UniProtKB/TrEMBL
      A0A178UVC9, A0A654FLY9
      Conserved Domains (2) summary
      COG5594
      Location:63 → 681
      COG5594; Uncharacterized integral membrane protein [Function unknown]
      pfam02714
      Location:375 → 646
      RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate

    2. NM_178966.1 → NP_849297.1  ERD (early-responsive to dehydration stress) family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849297.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A097NUN6, Q93ZR7, Q9XEA1
      UniProtKB/TrEMBL
      A0A178UVC9, A0A654FLY9
      Conserved Domains (2) summary
      COG5594
      Location:63 → 681
      COG5594; Uncharacterized integral membrane protein [Function unknown]
      pfam02714
      Location:375 → 646
      RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate

    3. NM_178965.2 → NP_849296.1  ERD (early-responsive to dehydration stress) family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849296.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A097NUN6, Q93ZR7, Q9XEA1
      UniProtKB/TrEMBL
      A0A178UVC9, A0A654FLY9
      Conserved Domains (2) summary
      COG5594
      Location:63 → 681
      COG5594; Uncharacterized integral membrane protein [Function unknown]
      pfam02714
      Location:375 → 646
      RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XEA1.1

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