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    MAD2 DNA-binding HORMA family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 822195, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MAD2
    Official Full Name
    DNA-binding HORMA family protein
    Primary source
    TAIR:AT3G25980
    Locus tag
    AT3G25980
    See related
    Araport:AT3G25980
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtMAD2; MITOTIC ARREST-DEFICIENT 2
    Summary
    Encodes MAD2 (MITOTIC ARREST-DEFICIENT 2). May have the spindle assembly checkpoint protein functions conserved from yeast to humans.
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    Genomic context

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    See MAD2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    7
    Sequence:
    Chromosome: 3; NC_003074.8 (9503056..9504680)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Pyruvate kinase family protein Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene Homeodomain-like superfamily protein Neighboring gene Ribonuclease inhibitor Neighboring gene Galactose oxidase/kelch repeat superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional interaction between the Arabidopsis orthologs of spindle assembly checkpoint proteins MAD1 and MAD2 and the nucleoporin NUA. Ding D, et al. Plant Mol Biol, 2012 Jun. PMID 22457071
    2. Spindle assembly checkpoint protein dynamics reveal conserved and unsuspected roles in plant cell division. Caillaud MC, et al. PLoS One, 2009 Aug 27. PMID 19710914, Free PMC Article
    3. Endopolyploidization and flowering time are antagonistically regulated by checkpoint component MAD1 and immunity modulator MOS1. Bao Z, et al. Nat Commun, 2014 Nov 28. PMID 25429892
    4. Conserved CDC20 cell cycle functions are carried out by two of the five isoforms in Arabidopsis thaliana. Kevei Z, et al. PLoS One, 2011. PMID 21687678, Free PMC Article
    5. Targeted interactomics reveals a complex core cell cycle machinery in Arabidopsis thaliana. Van Leene J, et al. Mol Syst Biol, 2010 Aug 10. PMID 20706207, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001338771.1
    NM_001338772.1
    NM_113502.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within mitotic spindle assembly checkpoint signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromocenter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in spindle microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA-binding HORMA family protein
    NP_001189978.1
    • MITOTIC ARREST-DEFICIENT 2 (MAD2); CONTAINS InterPro DOMAIN/s: DNA-binding HORMA (InterPro:IPR003511).
    NP_189227.1
    • MITOTIC ARREST-DEFICIENT 2 (MAD2); CONTAINS InterPro DOMAIN/s: DNA-binding HORMA (InterPro:IPR003511); Has 609 Blast hits to 608 proteins in 183 species: Archae - 0; Bacteria - 0; Metazoa - 312; Fungi - 177; Plants - 74; Viruses - 0; Other Eukaryotes - 46 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      9503056..9504680
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001203049.1 → NP_001189978.1  DNA-binding HORMA family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001189978.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654FAN7, F4JBB7
      Conserved Domains (1) summary
      pfam02301
      Location:14 → 188
      HORMA; HORMA domain

    2. NM_113502.3 → NP_189227.1  DNA-binding HORMA family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_189227.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q67YV5, Q9LU93
      UniProtKB/TrEMBL
      A0A5S9XG45, A0A654FAN7
      Conserved Domains (1) summary
      pfam02301
      Location:17 → 192
      HORMA; HORMA domain

    3. NM_001338772.1 → NP_001327186.1  DNA-binding HORMA family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LRJ1

    4. NM_001338771.1 → NP_001327185.1  DNA-binding HORMA family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LRJ1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LU93.1

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