U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    CLE41 CLAVATA3/ESR-RELATED 41 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 822075, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CLE41
    Official Full Name
    CLAVATA3/ESR-RELATED 41
    Primary source
    TAIR:AT3G24770
    Locus tag
    AT3G24770
    See related
    Araport:AT3G24770
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CLAVATA3/ESR-RELATED 41
    Summary
    Belongs to a large gene family, called CLE for CLAVATA3/ESR-related, encoding small peptides with conserved carboxyl termini. The C-terminal 12 amino acid sequence of CLE41 is identical to that of a dodeca peptide (TDIF, tracheary element differentiation inhibitory factor) isolated from Arabidopsis and functions as a suppressor of plant stem cell differentiation. TDIF sequence is also identical to the C-terminal 12 amino acids of CLE44 (At4g13195). The protein is expressed in the vascular system and is involved in axillary bud formation.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CLE41 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    1
    Sequence:
    Chromosome: 3; NC_003074.8 (9046293..9047463)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene Galactose oxidase/kelch repeat superfamily protein Neighboring gene miscRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Crystal structure of PXY-TDIF complex reveals a conserved recognition mechanism among CLE peptide-receptor pairs. Zhang H, et al. Cell Res, 2016 May. PMID 27055373, Free PMC Article
    2. Wood Formation in Trees Is Increased by Manipulating PXY-Regulated Cell Division. Etchells JP, et al. Curr Biol, 2015 Apr 20. PMID 25866390, Free PMC Article
    3. Dodeca-CLE peptides as suppressors of plant stem cell differentiation. Ito Y, et al. Science, 2006 Aug 11. PMID 16902140
    4. The PXY-CLE41 receptor ligand pair defines a multifunctional pathway that controls the rate and orientation of vascular cell division. Etchells JP, et al. Development, 2010 Mar. PMID 20147378
    5. Non-cell-autonomous control of vascular stem cell fate by a CLE peptide/receptor system. Hirakawa Y, et al. Proc Natl Acad Sci U S A, 2008 Sep 30. PMID 18812507, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data provide a structural template for understanding the recognition mechanism of CLE peptides by their receptors. The crystal structure of TDIF in complex with its receptor PXY, a leucine-rich repeat receptor kinase (LRR-RK), is reported.[CLE41]
      Title: Crystal structure of PXY-TDIF complex reveals a conserved recognition mechanism among CLE peptide-receptor pairs.
    2. Data demonstrate that the PXY-CLE pathway has evolved to regulate secondary growth and manipulating this pathway can result in dramatically increased tree growth and productivity.
      Title: Wood Formation in Trees Is Increased by Manipulating PXY-Regulated Cell Division.
    3. PXY-CLE41 receptor ligand pair defines a multifunctional pathway that controls the rate and orientation of vascular cell division.
      Title: The PXY-CLE41 receptor ligand pair defines a multifunctional pathway that controls the rate and orientation of vascular cell division.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help
    NM_113389.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables receptor serine/threonine kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within axillary shoot meristem initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell-cell signaling involved in cell fate commitment ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in maintenance of root meristem identity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phloem development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within phloem or xylem histogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within phloem or xylem histogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in procambium histogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within secondary shoot formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in xylem development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apoplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apoplast ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    CLAVATA3/ESR-RELATED 41
    NP_566754.1
    • CLAVATA3/ESR-RELATED 41 (CLE41); BEST Arabidopsis thaliana protein match is: CLAVATA3/ESR-RELATED 44 (TAIR:AT4G13195.1); Has 25 Blast hits to 25 proteins in 7 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 25; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      9046293..9047463
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_113389.1 → NP_566754.1  CLAVATA3/ESR-RELATED 41 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566754.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q84W98, Q8LB23
      UniProtKB/TrEMBL
      A0A178VDH8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q84W98.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools