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    SCO3 SNOWY COTYLEDON protein (DUF566) [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821494, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SCO3
    Official Full Name
    SNOWY COTYLEDON protein (DUF566)
    Primary source
    TAIR:AT3G19570
    Locus tag
    AT3G19570
    See related
    Araport:AT3G19570
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    QWRF domain containing 1; QWRF1; SNOWY COTYLEDON 3
    Summary
    Encodes SCO3 (snowy cotyledon3), a member of a largely uncharacterized protein family unique to the plant kingdom. The sco3-1 mutation alters chloroplast morphology and development, reduces chlorophyll accumulation, impairs thylakoid formation and photosynthesis in seedlings, and results in photoinhibition under extreme CO(2) concentrations in mature leaves. SCO3 is targeted to the periphery of peroxisomes.
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    Genomic context

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    See SCO3 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    6
    Sequence:
    Chromosome: 3; NC_003074.8 (6797471..6801835)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene F-box family protein Neighboring gene ncRNA Neighboring gene F-box/associated interaction domain protein Neighboring gene zinc-finger protein 2 Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The cytoskeleton and the peroxisomal-targeted snowy cotyledon3 protein are required for chloroplast development in Arabidopsis. Albrecht V, et al. Plant Cell, 2010 Oct. PMID 20978221, Free PMC Article
    2. Arabidopsis QWRF1 and QWRF2 Redundantly Modulate Cortical Microtubule Arrangement in Floral Organ Growth and Fertility. Ma H, et al. Front Cell Dev Biol, 2021. PMID 33634133, Free PMC Article
    3. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article
    4. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A mutation in SCO3 compromises chloroplast biogenesis and structure. Localization to peroxisomes is necessary for its function.
      Title: The cytoskeleton and the peroxisomal-targeted snowy cotyledon3 protein are required for chloroplast development in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001338408.1
    NM_001338409.1
    NM_112847.3
    NM_180283.5

    Gene Ontology Provided by TAIR

    Process Evidence Code Pubs
    acts_upstream_of_or_within chloroplast organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SNOWY COTYLEDON protein (DUF566)
    NP_188591.2
    • Family of unknown function (DUF566); CONTAINS InterPro DOMAIN/s: Protein of unknown function DUF566 (InterPro:IPR007573); BEST Arabidopsis thaliana protein match is: Family of unknown function (DUF566) (TAIR:AT1G49890.1); Has 4891 Blast hits to 1814 proteins in 299 species: Archae - 6; Bacteria - 1296; Metazoa - 1110; Fungi - 663; Plants - 249; Viruses - 59; Other Eukaryotes - 1508 (source: NCBI BLink).
    NP_850614.1
    • Family of unknown function (DUF566); CONTAINS InterPro DOMAIN/s: Protein of unknown function DUF566 (InterPro:IPR007573); BEST Arabidopsis thaliana protein match is: Family of unknown function (DUF566) (TAIR:AT1G49890.1); Has 4892 Blast hits to 1821 proteins in 299 species: Archae - 6; Bacteria - 1294; Metazoa - 1107; Fungi - 667; Plants - 251; Viruses - 59; Other Eukaryotes - 1508 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      6797471..6801835
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180283.5 → NP_850614.1  SNOWY COTYLEDON protein (DUF566) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850614.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q3EB40, Q8GXD9, Q9LJN9
      UniProtKB/TrEMBL
      A0A178VB87
      Conserved Domains (1) summary
      pfam04484
      Location:298 → 614
      DUF566; Family of unknown function (DUF566)

    2. NM_001338408.1 → NP_001326401.1  SNOWY COTYLEDON protein (DUF566) [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VB87, A0A1I9LP61

    3. NM_001338409.1 → NP_001326402.1  SNOWY COTYLEDON protein (DUF566) [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VB87, A0A1I9LP61

    4. NM_112847.3 → NP_188591.2  SNOWY COTYLEDON protein (DUF566) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188591.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VB87
      Conserved Domains (1) summary
      pfam04484
      Location:298 → 614
      DUF566; Family of unknown function (DUF566)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8GXD9.1

    Gene LinkOut

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