UGP1 UDP-GLUCOSE PYROPHOSPHORYLASE 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: UGP1
Official Full Name: UDP-GLUCOSE PYROPHOSPHORYLASE 1
Primary source: TAIR:AT3G03250
Locus tag: AT3G03250
See related: Araport:AT3G03250
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AtUGP1; T17B22.6; T17B22_6; UDP-glucose pyrophosphorylase; UDP-GLUCOSE PYROPHOSPHORYLASE 1; UGP; UGPASE
Summary: Is thought to encode a cytosolic UDP-glucose pyrophosphorylase with strong similarity to potato UTP--glucose-1-phosphate uridylyltransferase. Downregulated by flooding.
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Genomic context

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See UGP1 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 19

Sequence:: Chromosome: 3; NC_003074.8 (749309..754161, complement)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

UGP1 is a cell death regulator.
Title: UDP-glucose pyrophosphorylase is a novel plant cell death regulator.
UGP1 and UGP2, are differentially expressed, with UGP1 being predominant. UGP1 is closely co-regulated with carbohydrate metabolism, late embryogenesis and seed loading, while UGP2 with stress response, fertilized flowers and photosynthetic genes. [UGP1]
Title: UDP-glucose pyrophosphorylase is not rate limiting, but is essential in Arabidopsis.
AtUGP1 and AtUGP2 genes are functionally redundant and UGPase activity is essential for both vegetative and reproductive phases in Arabidopsis.
Title: UDP-glucose pyrophosphorylase is rate limiting in vegetative and reproductive phases in Arabidopsis thaliana.
The identification of a novel gene, UDP-glucose pyrophosphorylase3 (UGP3), required for sulfolipid biosynthesis, is described.
Title: A chloroplastic UDP-glucose pyrophosphorylase from Arabidopsis is the committed enzyme for the first step of sulfolipid biosynthesis.
Comparison of molecular masses of UGPases from root and leaf extracts revealed that the root protein was slightly larger, suggesting a post-translational modification.
Title: Molecular and kinetic characterization of two UDP-glucose pyrophosphorylases, products of distinct genes, from Arabidopsis.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001337461.1

Supported by ESTs:

NM_001337462.1

Supported by ESTs:

NM_111195.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables UTP:glucose-1-phosphate uridylyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in UDP-alpha-D-glucose metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within callose deposition in cell wall	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cellular response to phosphate starvation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within pollen development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within sucrose metabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in cytosol	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in pollen tube	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: UDP-GLUCOSE PYROPHOSPHORYLASE 1

NP_186975.1

UDP-GLUCOSE PYROPHOSPHORYLASE 1 (UGP1); FUNCTIONS IN: UTP:glucose-1-phosphate uridylyltransferase activity, nucleotidyltransferase activity; INVOLVED IN: in 6 processes; LOCATED IN: plasma membrane; EXPRESSED IN: 30 plant structures; EXPRESSED DURING: 17 growth stages; CONTAINS InterPro DOMAIN/s: UTP--glucose-1-phosphate uridylyltransferase, subgroup (InterPro:IPR016267), UTP--glucose-1-phosphate uridylyltransferase (InterPro:IPR002618); BEST Arabidopsis thaliana protein match is: UDP-glucose pyrophosphorylase 2 (TAIR:AT5G17310.2); Has 1425 Blast hits to 1421 proteins in 430 species: Archae - 0; Bacteria - 404; Metazoa - 339; Fungi - 309; Plants - 217; Viruses - 0; Other Eukaryotes - 156 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

749309..754161 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_111195.4 → NP_186975.1 UDP-GLUCOSE PYROPHOSPHORYLASE 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_186975.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9ASY1, Q9M9P3

UniProtKB/TrEMBL

A0A178V8F3, A0A5S9X8Z0, A0A654F576

Conserved Domains (1) summary

PLN02474
Location:1 → 469

PLN02474; UTP--glucose-1-phosphate uridylyltransferase
NM_001337461.1 → NP_001327658.1 UDP-GLUCOSE PYROPHOSPHORYLASE 1 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178V8F3, A0A1I9LT02
NM_001337462.1 → NP_001327659.1 UDP-GLUCOSE PYROPHOSPHORYLASE 1 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178V8F3, A0A1I9LT03