DEG7 DegP protease 7 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: DEG7
Official Full Name: DegP protease 7
Primary source: TAIR:AT3G03380
Locus tag: AT3G03380
See related: Araport:AT3G03380
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AT3G03390; DegP protease 7; DegP7; degradation of periplasmic proteins 7; T21P5.20; T21P5_20
Summary: Encodes a putative DegP protease.
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Genomic context

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See DEG7 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 24

Sequence:: Chromosome: 3; NC_003074.8 (799500..808540)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DEG7 forms trimeric complexes, but in contrast with other known DegP/HtrA proteases, DEG7 shows a new principle of oligomerization, where trimerization is based on the interactions between degenerated protease domains.
Title: A new principle of oligomerization of plant DEG7 protease based on interactions of degenerated protease domains.
Deg7 is a chloroplast stroma protein associated with the thylakoid membranes and that it is important for maintaining PSII function.
Title: The stromal chloroplast Deg7 protease participates in the repair of photosystem II after photoinhibition in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001337469.1

Supported by ESTs:

NM_111209.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables peptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within photoinhibition	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: DegP protease 7

NP_566204.2

DegP protease 7 (DegP7); CONTAINS InterPro DOMAIN/s: Serine/cysteine peptidase, trypsin-like (InterPro:IPR009003), Peptidase S1C, HrtA/DegP2/Q/S (InterPro:IPR001940), PDZ/DHR/GLGF (InterPro:IPR001478); BEST Arabidopsis thaliana protein match is: unknown protein (TAIR:AT3G03370.1); Has 8327 Blast hits to 7895 proteins in 2064 species: Archae - 65; Bacteria - 6254; Metazoa - 235; Fungi - 503; Plants - 137; Viruses - 0; Other Eukaryotes - 1133 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

799500..808540

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_111209.3 → NP_566204.2 DegP protease 7 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_566204.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8RY22, Q9SRP2, Q9SRP3

UniProtKB/TrEMBL

A0A178VKJ3

Conserved Domains (5) summary

COG0265
Location:39 → 372

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

cd00987
Location:280 → 366

PDZ_serine_protease; PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind ...

pfam12812
Location:373 → 446

PDZ_1; PDZ-like domain

pfam13365
Location:74 → 220

Trypsin_2; Trypsin-like peptidase domain

cl00117
Location:971 → 1047

PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
NM_001337469.1 → NP_001326670.1 DegP protease 7 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178VL82, A0A1I9LPZ9, A0A5S9X919, A0A654FE75

Conserved Domains (4) summary

COG0265
Location:39 → 372

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

TIGR02037
Location:789 → 1019

degP_htrA_DO; periplasmic serine protease, Do/DeqQ family

pfam13365
Location:611 → 765

Trypsin_2; Trypsin-like peptidase domain

cl00117
Location:373 → 446

PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...