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    CPA Subunits of heterodimeric actin filament capping protein Capz superfamily [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819717, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CPA
    Official Full Name
    Subunits of heterodimeric actin filament capping protein Capz superfamily
    Primary source
    TAIR:AT3G05520
    Locus tag
    AT3G05520
    See related
    Araport:AT3G05520
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtCPA; capping protein A; F22F7.25
    Summary
    Encodes a capping protein that acts as a phosphatidic acid biosensor and key transducer of fluxes in membrane signaling phospholipids into changes in actin cytoskeleton dynamics.
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    Genomic context

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    See CPA in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    11
    Sequence:
    Chromosome: 3; NC_003074.8 (1598449..1601437)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Rubber elongation factor protein (REF) Neighboring gene Phospholipid/glycerol acyltransferase family protein Neighboring gene tRNA-Glu Neighboring gene regulatory particle triple-A ATPase 5A Neighboring gene Methionine sulfoxide reductase (MSS4-like) family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Heterodimeric capping protein from Arabidopsis is a membrane-associated, actin-binding protein. Jimenez-Lopez JC, et al. Plant Physiol, 2014 Nov. PMID 25201878, Free PMC Article
    2. Capping protein modulates the dynamic behavior of actin filaments in response to phosphatidic acid in Arabidopsis. Li J, et al. Plant Cell, 2012 Sep. PMID 22960908, Free PMC Article
    3. Arabidopsis actin capping protein (AtCP) subunits have different expression patterns, and downregulation of AtCPB confers increased thermotolerance of Arabidopsis after heat shock stress. Wang J, et al. Plant Sci, 2012 Sep. PMID 22794924
    4. Analysis of the Arabidopsis nuclear proteome and its response to cold stress. Bae MS, et al. Plant J, 2003 Dec. PMID 14617066
    5. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. At3g05520 is moderately abundant in Arabidopsis tissues and present in a microsomal membrane fraction.At3g05520 is enriched on membrane-bound organelles such as the endoplasmic reticulum and Golgi.
      Title: Heterodimeric capping protein from Arabidopsis is a membrane-associated, actin-binding protein.
    2. Capping protein (CP) acts as a phosphatidic acid (PA) biosensor and key transducer of fluxes in membrane signaling phospholipids into changes in actin cytoskeleton dynamics.
      Title: Capping protein modulates the dynamic behavior of actin filaments in response to phosphatidic acid in Arabidopsis.
    3. AtCPA and AtCPB showed distinct expression patterns in vivo, and that downregulation of AtCPB conferred increased Arabidopsis thermotolerance after heat shock stress.
      Title: Arabidopsis actin capping protein (AtCP) subunits have different expression patterns, and downregulation of AtCPB confers increased thermotolerance of Arabidopsis after heat shock stress.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_001161121.1
    NM_111425.5

    Gene Ontology Provided by TAIR

    Process Evidence Code Pubs
    acts_upstream_of_or_within actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within actin filament capping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within actin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in barbed-end actin filament capping IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of F-actin capping protein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    Subunits of heterodimeric actin filament capping protein Capz superfamily
    NP_001154593.1
    • Subunits of heterodimeric actin filament capping protein Capz superfamily; FUNCTIONS IN: actin binding; INVOLVED IN: actin cytoskeleton organization; LOCATED IN: F-actin capping protein complex; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: F-actin capping protein, alpha subunit, actin binding (InterPro:IPR018315), F-actin capping protein, alpha subunit (InterPro:IPR002189), F-actin capping protein, alpha subunit, conserved site (InterPro:IPR017865); Has 69 Blast hits to 69 proteins in 37 species: Archae - 0; Bacteria - 0; Metazoa - 37; Fungi - 15; Plants - 8; Viruses - 0; Other Eukaryotes - 9 (source: NCBI BLink).
    NP_187203.1
    • Subunits of heterodimeric actin filament capping protein Capz superfamily; FUNCTIONS IN: actin binding; INVOLVED IN: actin cytoskeleton organization; LOCATED IN: nucleus, F-actin capping protein complex; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: F-actin capping protein, alpha subunit, actin binding (InterPro:IPR018315), F-actin capping protein, alpha subunit (InterPro:IPR002189), F-actin capping protein, alpha subunit, conserved site (InterPro:IPR017865); Has 649 Blast hits to 643 proteins in 214 species: Archae - 0; Bacteria - 0; Metazoa - 391; Fungi - 148; Plants - 37; Viruses - 0; Other Eukaryotes - 73 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      1598449..1601437
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001337589.1 → NP_001326001.1  Subunits of heterodimeric actin filament capping protein Capz superfamily [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VDQ1, A0A1I9LMY3

    2. NM_001161121.1 → NP_001154593.1  Subunits of heterodimeric actin filament capping protein Capz superfamily [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001154593.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9XAG8, F4J7C4
      Conserved Domains (1) summary
      pfam01267
      Location:19 → 299
      F-actin_cap_A; F-actin capping protein alpha subunit

    3. NM_111425.5 → NP_187203.1  Subunits of heterodimeric actin filament capping protein Capz superfamily [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187203.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O82631, Q9MA66
      UniProtKB/TrEMBL
      A0A178VDQ1, Q541X2
      Conserved Domains (1) summary
      pfam01267
      Location:19 → 299
      F-actin_cap_A; F-actin capping protein alpha subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O82631.2

    Gene LinkOut

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