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    PI4K GAMMA 4 phosphoinositide 4-kinase gamma 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819260, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PI4K GAMMA 4
    Official Full Name
    phosphoinositide 4-kinase gamma 4
    Primary source
    TAIR:AT2G46500
    Locus tag
    AT2G46500
    See related
    Araport:AT2G46500
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATPI4K GAMMA 4; F11C10.19; F11C10_19; phosphoinositide 4-kinase gamma 4; UBDK GAMMA 4; UBIQUITIN-LIKE DOMAIN KINASE GAMMA 4
    Summary
    Phosphoinositide kinase which undergo autophosphorylation and phosphorylate serine/threonine residues of protein substrates. Contains phosphoinositide 3/4-kinase and ubiquitin-like domains. Phosphorylates PUFD1 and RPN10 in vitro.
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    Genomic context

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    See PI4K GAMMA 4 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    2
    Sequence:
    Chromosome: 2; NC_003071.7 (19086492..19089229, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene RING/U-box superfamily protein Neighboring gene RING/U-box superfamily protein Neighboring gene succinate dehydrogenase subunit 4 Neighboring gene ABA-inducible BHLH-type transcription factor

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of novel candidate phosphatidic acid-binding proteins involved in the salt-stress response of Arabidopsis thaliana roots. McLoughlin F, et al. Biochem J, 2013 Mar 15. PMID 23323832
    2. Phosphatidylinositol 3-kinase and 4-kinase have distinct roles in intracellular trafficking of cellulose synthase complexes in Arabidopsis thaliana. Fujimoto M, et al. Plant Cell Physiol, 2015 Feb. PMID 25516570
    3. Characterization of a new family of protein kinases from Arabidopsis containing phosphoinositide 3/4-kinase and ubiquitin-like domains. Galvão RM, et al. Biochem J, 2008 Jan 1. PMID 17880284
    4. Integrative Analysis from the Epigenome to Translatome Uncovers Patterns of Dominant Nuclear Regulation during Transient Stress. Lee TA, et al. Plant Cell, 2019 Nov. PMID 31519798, Free PMC Article
    5. Arabidopsis G-protein interactome reveals connections to cell wall carbohydrates and morphogenesis. Klopffleisch K, et al. Mol Syst Biol, 2011 Sep 27. PMID 21952135, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PI4K and PI3K are required for distinct steps in secretory and/or endocytic trafficking of CESA3.
      Title: Phosphatidylinositol 3-kinase and 4-kinase have distinct roles in intracellular trafficking of cellulose synthase complexes in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001202833.1
    NM_130214.3
    NM_201971.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol 4-kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 1-phosphatidylinositol 4-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to hypoxia HEP PubMed 
    acts_upstream_of_or_within phosphatidylinositol phosphate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to salt stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    phosphoinositide 4-kinase gamma 4
    NP_001189762.1
    • phosphoinositide 4-kinase gamma 4 (PI4K GAMMA 4); CONTAINS InterPro DOMAIN/s: Ubiquitin subgroup (InterPro:IPR019956), Phosphatidylinositol 3-/4-kinase, catalytic (InterPro:IPR000403), Ubiquitin (InterPro:IPR000626), Ubiquitin supergroup (InterPro:IPR019955); BEST Arabidopsis thaliana protein match is: Phosphatidylinositol 3- and 4-kinase; Ubiquitin family protein (TAIR:AT5G24240.1).
    NP_566076.1
    • phosphoinositide 4-kinase gamma 4 (PI4K GAMMA 4); CONTAINS InterPro DOMAIN/s: Phosphatidylinositol 3-/4-kinase, catalytic (InterPro:IPR000403), Ubiquitin subgroup (InterPro:IPR019956), Ubiquitin (InterPro:IPR000626), Ubiquitin supergroup (InterPro:IPR019955); BEST Arabidopsis thaliana protein match is: Phosphatidylinositol 3- and 4-kinase; Ubiquitin family protein (TAIR:AT5G24240.1); Has 12754 Blast hits to 4652 proteins in 669 species: Archae - 0; Bacteria - 30; Metazoa - 5285; Fungi - 1569; Plants - 3375; Viruses - 284; Other Eukaryotes - 2211 (source: NCBI BLink).
    NP_973700.1
    • phosphoinositide 4-kinase gamma 4 (PI4K GAMMA 4); CONTAINS InterPro DOMAIN/s: Phosphatidylinositol 3-/4-kinase, catalytic (InterPro:IPR000403), Ubiquitin subgroup (InterPro:IPR019956), Ubiquitin (InterPro:IPR000626), Ubiquitin supergroup (InterPro:IPR019955); BEST Arabidopsis thaliana protein match is: Phosphatidylinositol 3- and 4-kinase; Ubiquitin family protein (TAIR:AT5G24240.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      19086492..19089229 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_201971.3 → NP_973700.1  phosphoinositide 4-kinase gamma 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973700.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DGU3, B9DHV3, Q9ZPY9
      UniProtKB/TrEMBL
      A0A178W060, A0A5S9X7H8
      Conserved Domains (3) summary
      cd17039
      Location:115 → 182
      Ubl_ubiquitin_like; ubiquitin-like (Ubl) domain found in ubiquitin and ubiquitin-like Ubl proteins
      pfam00454
      Location:264 → 513
      PI3_PI4_kinase; Phosphatidylinositol 3- and 4-kinase
      cl28922
      Location:39 → 107
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    2. NM_130214.3 → NP_566076.1  phosphoinositide 4-kinase gamma 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566076.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DGU3, B9DHV3, Q9ZPY9
      UniProtKB/TrEMBL
      A0A178W060, A0A5S9X7H8
      Conserved Domains (3) summary
      cd17039
      Location:115 → 182
      Ubl_ubiquitin_like; ubiquitin-like (Ubl) domain found in ubiquitin and ubiquitin-like Ubl proteins
      pfam00454
      Location:264 → 513
      PI3_PI4_kinase; Phosphatidylinositol 3- and 4-kinase
      cl28922
      Location:39 → 107
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    3. NM_001202833.1 → NP_001189762.1  phosphoinositide 4-kinase gamma 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001189762.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4IJ57
      Conserved Domains (4) summary
      smart00213
      Location:40 → 106
      UBQ; Ubiquitin homologues
      pfam00240
      Location:40 → 108
      ubiquitin; Ubiquitin family
      cl00155
      Location:115 → 184
      UBQ; Ubiquitin-like proteins
      cl21453
      Location:265 → 387
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZPY9.1

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