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    AUR3 ataurora3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819157, updated on 18-Sep-2024

    Summary

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    Official Symbol
    AUR3
    Official Full Name
    ataurora3
    Primary source
    TAIR:AT2G45490
    Locus tag
    AT2G45490
    See related
    Araport:AT2G45490
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtAUR3; ataurora3; F17K2.2
    Summary
    Encodes a member of a family of Ser/Thr kinases whose activities peak during cell division. Transcripts are abundant in tissues rich in dividing cells like roots and flowers but are low or absent in fully expanded leaves and stems. In interphase cells, the protein is predominantly nuclear. During mitosis, the protein associates with plant-specific cytoskeletal structures (preprophase band, phragmoplast, nascent cell plate) that are necessary for cytokinesis as well as with the microtubule spindle. The protein is concentrated in nuclear dots arranged around the nucleolus and the nuclear periphery in early prophase cells.
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    Genomic context

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    See AUR3 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    6
    Sequence:
    Chromosome: 2; NC_003071.7 (18747509..18749215, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene SMAD/FHA domain-containing protein Neighboring gene FASCICLIN-like arabinogalactan protein 8 Neighboring gene growth-regulating factor 9 Neighboring gene AAA-type ATPase family protein Neighboring gene cytochrome P450, family 704, subfamily A, polypeptide 2 Neighboring gene coiled-coil protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Deregulated Phosphorylation of CENH3 at Ser65 Affects the Development of Floral Meristems in Arabidopsis thaliana. Demidov D, et al. Front Plant Sci, 2019. PMID 31404279, Free PMC Article
    2. Plant Aurora kinases interact with and phosphorylate transcription factors. Takagi M, et al. J Plant Res, 2016 Nov. PMID 27734173
    3. Identification and characterization of plant Haspin kinase as a histone H3 threonine kinase. Kurihara D, et al. BMC Plant Biol, 2011 Apr 28. PMID 21527018, Free PMC Article
    4. Functional Analysis of the Plant Chromosomal Passenger Complex. Komaki S, et al. Plant Physiol, 2020 Aug. PMID 32461300, Free PMC Article
    5. Altered expression of Aurora kinases in Arabidopsis results in aneu- and polyploidization. Demidov D, et al. Plant J, 2014 Nov. PMID 25146886

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AtAUR1 and AtAUR3 have both redundant and distinct functions through interactions with transcription factors (TFs). In addition, database analysis revealed that most of the highly AtAUR-interacting TFs contained a detectable phosphopeptide that was consistent with the consensus motifs for human AURs, suggesting that these TFs are substrates of the AtAURs.
      Title: Plant Aurora kinases interact with and phosphorylate transcription factors.
    2. Aurora kinases play an essential role in the monitoring of meiosis in plants.
      Title: Altered expression of Aurora kinases in Arabidopsis results in aneu- and polyploidization.
    3. Aurora kinase AtAUR3 showed dot-like distribution on condensed chromosomes at prophase and then localized at the metaphase plate, and overexpression of AtAUR3 induces disassembly of spindle microtubules and alteration of orientation of cell division.
      Title: Characterization of plant Aurora kinases during mitosis.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_130111.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables histone H3S10 kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H3S28 kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in post-translational protein modification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome, centromeric region HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in spindle HDA PubMed 

    General protein information

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    Preferred Names
    ataurora3
    NP_182073.1
    • ataurora3 (AUR3); CONTAINS InterPro DOMAIN/s: Spindle assembly checkpoint kinase (InterPro:IPR020663), Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: ataurora1 (TAIR:AT4G32830.1); Has 132422 Blast hits to 130217 proteins in 4585 species: Archae - 167; Bacteria - 15261; Metazoa - 49222; Fungi - 13102; Plants - 32389; Viruses - 552; Other Eukaryotes - 21729 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      18747509..18749215 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001337135.1 → NP_001323763.1  ataurora3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VQP5, A0A1P8AY43, A0A384LN72

    2. NM_130111.4 → NP_182073.1  ataurora3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_182073.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O64629
      UniProtKB/TrEMBL
      A0A178VSR7, A0A5S9X783, A0A7G2EGI5
      Conserved Domains (1) summary
      cd14007
      Location:21 → 274
      STKc_Aurora; Catalytic domain of the Serine/Threonine kinase, Aurora kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O64629.1

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