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    CYP98A3 cytochrome P450, family 98, subfamily A, polypeptide 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818686, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CYP98A3
    Official Full Name
    cytochrome P450, family 98, subfamily A, polypeptide 3
    Primary source
    TAIR:AT2G40890
    Locus tag
    AT2G40890
    See related
    Araport:AT2G40890
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    cytochrome P450; family 98; polypeptide 3; REDUCED EPIDERMAL FLUORESCENCE 8; REF8; subfamily A; T20B5.9; T20B5_9
    Summary
    encodes coumarate 3-hydroxylase (C3H), a P450-dependent monooxygenase. Involved in lignin biosynthesis and flavonoid biosynthesis. Also affects the biosynthesis of coumarins such as scopoletin and scopolin as a branching-out-pathway from the phenylpropanoid acid level.
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    Genomic context

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    See CYP98A3 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    3
    Sequence:
    Chromosome: 2; NC_003071.7 (17058053..17060652, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene disproportionating enzyme 2 Neighboring gene phosphoinositide 4-kinase gamma 1 Neighboring gene protein kinase family protein / protein phosphatase 2C (PP2C) family protein Neighboring gene cystatin A Neighboring gene ncRNA Neighboring gene nodulin MtN21 /EamA-like transporter family protein Neighboring gene F-box and associated interaction domains-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Chemically induced conditional rescue of the reduced epidermal fluorescence8 mutant of Arabidopsis reveals rapid restoration of growth and selective turnover of secondary metabolite pools. Kim JI, et al. Plant Physiol, 2014 Feb. PMID 24381065, Free PMC Article
    2. Accumulation of coumarins in Arabidopsis thaliana. Kai K, et al. Phytochemistry, 2006 Feb. PMID 16405932
    3. A coumaroyl-ester-3-hydroxylase insertion mutant reveals the existence of nonredundant meta-hydroxylation pathways and essential roles for phenolic precursors in cell expansion and plant growth. Abdulrazzak N, et al. Plant Physiol, 2006 Jan. PMID 16377748, Free PMC Article
    4. CYP98A3 from Arabidopsis thaliana is a 3'-hydroxylase of phenolic esters, a missing link in the phenylpropanoid pathway. Schoch G, et al. J Biol Chem, 2001 Sep 28. PMID 11429408
    5. Transcriptional control of monolignol biosynthesis in Pinus taeda: factors affecting monolignol ratios and carbon allocation in phenylpropanoid metabolism. Anterola AM, et al. J Biol Chem, 2002 May 24. PMID 11891223

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_180006.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables p-coumarate 3-hydroxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables p-coumarate 3-hydroxylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within coumarin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within flavonoid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lignin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lignin biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within phenylpropanoid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    cytochrome P450, family 98, subfamily A, polypeptide 3
    NP_850337.1
    • cytochrome P450, family 98, subfamily A, polypeptide 3 (CYP98A3); FUNCTIONS IN: monooxygenase activity, p-coumarate 3-hydroxylase activity; INVOLVED IN: coumarin biosynthetic process, lignin biosynthetic process, phenylpropanoid biosynthetic process, flavonoid biosynthetic process; LOCATED IN: mitochondrion, endoplasmic reticulum, plasma membrane, microsome; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, E-class, group I (InterPro:IPR002401), Cytochrome P450, conserved site (InterPro:IPR017972); BEST Arabidopsis thaliana protein match is: cytochrome P450, family 98, subfamily A, polypeptide 9 (TAIR:AT1G74550.1); Has 33899 Blast hits to 33682 proteins in 1752 species: Archae - 48; Bacteria - 3997; Metazoa - 11870; Fungi - 7164; Plants - 9566; Viruses - 3; Other Eukaryotes - 1251 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      17058053..17060652 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180006.2 → NP_850337.1  cytochrome P450, family 98, subfamily A, polypeptide 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850337.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22203, Q0WWH4, Q940C7
      UniProtKB/TrEMBL
      A0A178VTT8, A0A5S9X5V5
      Conserved Domains (1) summary
      cd20656
      Location:58 → 490
      CYP98; cytochrome P450 family 98
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O22203.1

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