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    PXN Mitochondrial substrate carrier family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818584, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PXN
    Official Full Name
    Mitochondrial substrate carrier family protein
    Primary source
    TAIR:AT2G39970
    Locus tag
    AT2G39970
    See related
    Araport:AT2G39970
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ABERRANT PEROXISOME MORPHOLOGY 3; APEM3; peroxisomal membrane protein 38; peroxisomal NAD carrier; PMP38; T28M21.13; T28M21_13
    Summary
    Encodes peroxisomal membrane protein 38 (PMP38). Mutation in this protein results in enlargement of peroxisomes. Delivers NAD+ for optimal fatty acid degradation during storage oil mobilization.
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    Genomic context

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    See PXN in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    11
    Sequence:
    Chromosome: 2; NC_003071.7 (16683832..16686815, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene flocculation protein Neighboring gene Microsomal signal peptidase 25 kDa subunit (SPC25) Neighboring gene HXXXD-type acyl-transferase family protein Neighboring gene uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Peroxisomal NAD Carrier from Arabidopsis Imports NAD in Exchange with AMP. van Roermund CW, et al. Plant Physiol, 2016 Jul. PMID 27208243, Free PMC Article
    2. A peroxisomal carrier delivers NAD⁺ and contributes to optimal fatty acid degradation during storage oil mobilization. Bernhardt K, et al. Plant J, 2012 Jan. PMID 21895810
    3. Developmental analysis of a putative ATP/ADP carrier protein localized on glyoxysomal membranes during the peroxisome transition in pumpkin cotyledons. Fukao Y, et al. Plant Cell Physiol, 2001 Aug. PMID 11522909
    4. A defect of peroxisomal membrane protein 38 causes enlargement of peroxisomes. Mano S, et al. Plant Cell Physiol, 2011 Dec. PMID 22034551
    5. A proteomics dissection of Arabidopsis thaliana vacuoles isolated from cell culture. Jaquinod M, et al. Mol Cell Proteomics, 2007 Mar. PMID 17151019, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PXN acts as a NAD/AMP transporter.PXN imports cytosolic NAD into plant peroxisomes. PXN was not able to function as a CoA transporter or a redox shuttle by mediating a NAD/NADH exchange.
      Title: The Peroxisomal NAD Carrier from Arabidopsis Imports NAD in Exchange with AMP.
    2. APEM3/PMP38 plays a role distinct from that of AtPNC1 and AtPNC2. PMP38 belongs to the mitochondrial carrier family protein. Defect of PMP38 causes enlargement of peroxisomes.[PMP38]
      Title: A defect of peroxisomal membrane protein 38 causes enlargement of peroxisomes.
    3. At2g39970 delivers NAD(+) for optimal fatty acid degradation during storage oil mobilization.
      Title: A peroxisomal carrier delivers NAD⁺ and contributes to optimal fatty acid degradation during storage oil mobilization.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_129555.4

    Gene Ontology Provided by TAIR

    Process Evidence Code Pubs
    acts_upstream_of_or_within NAD transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of peroxisome size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in peroxisomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plant-type vacuole HDA PubMed 

    General protein information

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    Preferred Names
    Mitochondrial substrate carrier family protein
    NP_181526.1
    • Mitochondrial substrate carrier family protein; FUNCTIONS IN: binding; INVOLVED IN: transport, transmembrane transport; LOCATED IN: mitochondrial inner membrane, peroxisomal membrane, plasma membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Mitochondrial substrate carrier (InterPro:IPR001993), Mitochondrial substrate/solute carrier (InterPro:IPR018108); BEST Arabidopsis thaliana protein match is: folate transporter 1 (TAIR:AT5G66380.1); Has 16603 Blast hits to 11434 proteins in 397 species: Archae - 0; Bacteria - 4; Metazoa - 7348; Fungi - 4678; Plants - 2931; Viruses - 0; Other Eukaryotes - 1642 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      16683832..16686815 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129555.4 → NP_181526.1  Mitochondrial substrate carrier family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_181526.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04200, Q8L9P5
      UniProtKB/TrEMBL
      A0A178VUN6, A0A5S9X5K7, A0A7G2ECZ2
      Conserved Domains (1) summary
      pfam00153
      Location:227 → 319
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O04200.1

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