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    SAE2 SUMO-activating enzyme 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816686, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SAE2
    Official Full Name
    SUMO-activating enzyme 2
    Primary source
    TAIR:AT2G21470
    Locus tag
    AT2G21470
    See related
    Araport:AT2G21470
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATSAE2; EMB2764; EMBRYO DEFECTIVE 2764; F3K23.23; F3K23_23; SUMO-activating enzyme 2; SUMO-ACTIVATING ENZYME 2
    Summary
    Encodes one of the two subunits of the SUMO activation enzyme required during sumolation. Sumolation is a post-translational protein modification process similar to ubiquitination during which a polypeptide (SUMO) is covalently attached to a target protein.
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    Genomic context

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    See SAE2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    11
    Sequence:
    Chromosome: 2; NC_003071.7 (9198569..9202487)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Defensin-like (DEFL) family protein Neighboring gene Malectin/receptor-like protein kinase family protein Neighboring gene dehydrin LEA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Diversification of SUMO-activating enzyme in Arabidopsis: implications in SUMO conjugation. Castaño-Miquel L, et al. Mol Plant, 2013 Sep. PMID 23482370
    2. Genetic analysis of SUMOylation in Arabidopsis: conjugation of SUMO1 and SUMO2 to nuclear proteins is essential. Saracco SA, et al. Plant Physiol, 2007 Sep. PMID 17644626, Free PMC Article
    3. The small ubiquitin-like modifier (SUMO) protein modification system in Arabidopsis. Accumulation of SUMO1 and -2 conjugates is increased by stress. Kurepa J, et al. J Biol Chem, 2003 Feb 28. PMID 12482876
    4. SUMO-conjugating and SUMO-deconjugating enzymes from Arabidopsis. Colby T, et al. Plant Physiol, 2006 Sep. PMID 16920872, Free PMC Article
    5. Small Ubiquitin-like Modifier protein SUMO enables plants to control growth independently of the phytohormone gibberellin. Conti L, et al. Dev Cell, 2014 Jan 13. PMID 24434138

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_127719.4
    NM_201777.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables SUMO activating enzyme activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables SUMO activating enzyme activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein sumoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein sumoylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein sumoylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    SUMO-activating enzyme 2
    NP_001189570.1
    • SUMO-activating enzyme 2 (SAE2); CONTAINS InterPro DOMAIN/s: Ubiquitin-activating enzyme repeat (InterPro:IPR000127), Ubiquitin-activating enzyme (InterPro:IPR019572), UBA/THIF-type NAD/FAD binding fold (InterPro:IPR000594), Molybdenum cofactor biosynthesis, MoeB (InterPro:IPR009036), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: E1 C-terminal related 1 (TAIR:AT5G19180.1).
    NP_179742.2
    • SUMO-activating enzyme 2 (SAE2); CONTAINS InterPro DOMAIN/s: Ubiquitin-activating enzyme repeat (InterPro:IPR000127), Ubiquitin-activating enzyme (InterPro:IPR019572), UBA/THIF-type NAD/FAD binding fold (InterPro:IPR000594), Molybdenum cofactor biosynthesis, MoeB (InterPro:IPR009036), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: E1 C-terminal related 1 (TAIR:AT5G19180.1); Has 14680 Blast hits to 13838 proteins in 2422 species: Archae - 213; Bacteria - 8268; Metazoa - 1751; Fungi - 1135; Plants - 581; Viruses - 0; Other Eukaryotes - 2732 (source: NCBI BLink).
    NP_973506.1
    • SUMO-activating enzyme 2 (SAE2); CONTAINS InterPro DOMAIN/s: Ubiquitin-activating enzyme repeat (InterPro:IPR000127), Ubiquitin-activating enzyme (InterPro:IPR019572), UBA/THIF-type NAD/FAD binding fold (InterPro:IPR000594), Molybdenum cofactor biosynthesis, MoeB (InterPro:IPR009036), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: E1 C-terminal related 1 (TAIR:AT5G19180.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      9198569..9202487
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202641.1 → NP_001189570.1  SUMO-activating enzyme 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001189570.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654EUU7, F4IHI1
      Conserved Domains (3) summary
      cd01489
      Location:14 → 438
      Uba2_SUMO; Ubiquitin activating enzyme (E1) subunit UBA2. UBA2 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
      pfam00899
      Location:7 → 172
      ThiF; ThiF family
      pfam14732
      Location:445 → 534
      UAE_UbL; Ubiquitin/SUMO-activating enzyme ubiquitin-like domain

    2. NM_127719.4 → NP_179742.2  SUMO-activating enzyme 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_179742.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9WZW4, A0A654EUU7
      Conserved Domains (2) summary
      cd01489
      Location:14 → 435
      Uba2_SUMO; Ubiquitin activating enzyme (E1) subunit UBA2. UBA2 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
      pfam14732
      Location:442 → 531
      UAE_UbL; Ubiquitin/SUMO-activating enzyme ubiquitin-like domain

    3. NM_201777.1 → NP_973506.1  SUMO-activating enzyme 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973506.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q84YI5, Q8GYC2, Q8LKN2, Q9SJT1
      UniProtKB/TrEMBL
      A0A654EUU7
      Conserved Domains (3) summary
      cd01489
      Location:14 → 435
      Uba2_SUMO; Ubiquitin activating enzyme (E1) subunit UBA2. UBA2 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
      pfam00899
      Location:7 → 172
      ThiF; ThiF family
      pfam14732
      Location:442 → 531
      UAE_UbL; Ubiquitin/SUMO-activating enzyme ubiquitin-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SJT1.1

    Gene LinkOut

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