Ghdc GH3 domain containing [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ghdcprovided by MGI
Official Full Name: GH3 domain containingprovided by MGI
Primary source: MGI:MGI:1931556
See related: Ensembl:ENSMUSG00000017747 AllianceGenome:MGI:1931556
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D11Lgp1e
Summary: Predicted to enable acid-amino acid ligase activity. Located in endoplasmic reticulum. Orthologous to human GHDC (GH3 domain containing). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 11.2), kidney adult (RPKM 10.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 63.6 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (100656852..100661772, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (100766026..100770973, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acid-amino acid ligase activity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: GH3 domain-containing protein

Names: D11lgp1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001418306.1 → NP_001405235.1 GH3 domain-containing protein isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AL591466

UniProtKB/TrEMBL

Q3UXS5
NM_031871.2 → NP_114077.1 GH3 domain-containing protein isoform 1 precursor

See identical proteins and their annotated locations for NP_114077.1

Status: VALIDATED

Source sequence(s)

AL591466

Consensus CDS

CCDS25437.1

UniProtKB/Swiss-Prot

A2A5D7, Q99J23, Q99J92

UniProtKB/TrEMBL

Q3UNZ1, Q3UXS5

Related

ENSMUSP00000017891.8, ENSMUST00000017891.14

Conserved Domains (2) summary

cl21606
Location:207 → 532

PLN02247; indole-3-acetic acid-amido synthetase

pfam03321
Location:55 → 500

GH3; GH3 auxin-responsive promoter