U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    spns1 SPNS lysolipid transporter 1, lysophospholipid [ Danio rerio (zebrafish) ]

    Gene ID: 799873, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    spns1provided by ZNC
    Official Full Name
    SPNS lysolipid transporter 1, lysophospholipidprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-020228-1
    See related
    Ensembl:ENSDARG00000011925 AllianceGenome:ZFIN:ZDB-GENE-020228-1
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    nrs; spinl; wu:fb95b12; wu:fi37e11; etID64740.3
    Summary
    Predicted to enable transmembrane transporter activity. Acts upstream of or within autophagosome maturation and cellular senescence. Predicted to be located in lysosomal membrane. Predicted to be active in membrane. Is expressed in yolk syncytial layer. Orthologous to human SPNS1 (SPNS lysolipid transporter 1, lysophospholipid). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See spns1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (15455319..15475117, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (15305519..15325332, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene ataxin 2-like Neighboring gene si:dkey-56d12.4 Neighboring gene linker for activation of T cells Neighboring gene nuclear factor of activated T cells 2 interacting protein Neighboring gene SAGA complex associated factor 29

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Zebrafish yolk-specific not really started (nrs) gene is a vertebrate homolog of the Drosophila spinster gene and is essential for embryogenesis. Young RM, et al. Dev Dyn, 2002 Mar. PMID 11836794
    2. Spns1 is a lysophospholipid transporter mediating lysosomal phospholipid salvage. He M, et al. Proc Natl Acad Sci U S A, 2022 Oct 4. PMID 36161949, Free PMC Article
    3. Carbofuran accelerates the cellular senescence and declines the life span of spns1 mutant zebrafish. Khan A, et al. J Cell Mol Med, 2021 Jan. PMID 33277797, Free PMC Article
    4. Autolysosome biogenesis and developmental senescence are regulated by both Spns1 and v-ATPase. Sasaki T, et al. Autophagy, 2017 Feb. PMID 27875093, Free PMC Article
    5. Aberrant autolysosomal regulation is linked to the induction of embryonic senescence: differential roles of Beclin 1 and p53 in vertebrate Spns1 deficiency. Sasaki T, et al. PLoS Genet, 2014 Jun. PMID 24967584, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Spns1 is a lysophospholipid transporter mediating lysosomal phospholipid salvage.
      Title: Spns1 is a lysophospholipid transporter mediating lysosomal phospholipid salvage.
    2. Carbofuran accelerates the cellular senescence and declines the life span of spns1 mutant zebrafish.
      Title: Carbofuran accelerates the cellular senescence and declines the life span of spns1 mutant zebrafish.
    3. Spns1 and the v-ATPase orchestrate proper autolysosomal biogenesis with optimal acidification that is critically linked to developmental senescence and survival.
      Title: Autolysosome biogenesis and developmental senescence are regulated by both Spns1 and v-ATPase.
    4. Spns1 operates during autophagy and senescence differentially with Beclin 1 and p53.
      Title: Aberrant autolysosomal regulation is linked to the induction of embryonic senescence: differential roles of Beclin 1 and p53 in vertebrate Spns1 deficiency.
    5. Zebrafish yolk-specific not really started (nrs) gene is a vertebrate homolog of the Drosophila spinster gene and is essential for embryogenesis.
      Title: Zebrafish yolk-specific not really started (nrs) gene is a vertebrate homolog of the Drosophila spinster gene and is essential for embryogenesis.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC55239

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within autophagosome maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within autophagy IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular senescence IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular senescence IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    protein spinster homolog 1
    Names
    not really started
    protein not really started
    spinster homolog 1
    spinster-like protein

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153663.2 → NP_705949.2  protein spinster homolog 1

      Status: VALIDATED

      Source sequence(s)
      BX784026, CF999294, CK027241, CK029141, EH478886, EH585608, EH595239
      UniProtKB/Swiss-Prot
      Q7ZU13, Q8UVB7
      UniProtKB/TrEMBL
      A0A8M2BB36, G1K2F4
      Related
      ENSDARP00000009970.7, ENSDART00000025324.9
      Conserved Domains (2) summary
      cd06174
      Location:49 → 462
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:52 → 403
      MFS_1; Major Facilitator Superfamily

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      15455319..15475117 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005163832.5 → XP_005163889.1  protein spinster homolog 1 isoform X1

      UniProtKB/Swiss-Prot
      Q7ZU13, Q8UVB7
      UniProtKB/TrEMBL
      A0A8M2BB36, G1K2F4
      Related
      ENSDARP00000151373.1, ENSDART00000185302.1
      Conserved Domains (2) summary
      cd06174
      Location:49 → 462
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:52 → 403
      MFS_1; Major Facilitator Superfamily

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394524.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      110201..130131 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7ZU13.1 GenPept UniProtKB/Swiss-Prot:Q7ZU13

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools