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    ZNF212 zinc finger protein 212 [ Homo sapiens (human) ]

    Gene ID: 7988, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ZNF212provided by HGNC
    Official Full Name
    zinc finger protein 212provided by HGNC
    Primary source
    HGNC:HGNC:13004
    See related
    Ensembl:ENSG00000170260 MIM:602386; AllianceGenome:HGNC:13004
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF182; ZNFC150; C2H2-150
    Summary
    This gene belongs to the C2H2-type zinc finger gene family. The zinc finger proteins are involved in gene regulation and development, and are quite conserved throughout evolution. Like this gene product, a third of the zinc finger proteins containing C2H2 fingers also contain the KRAB domain, which has been found to be involved in protein-protein interactions. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 6.4), endometrium (RPKM 4.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF212 in Genome Data Viewer
    Location:
    7q36.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (149239651..149255606)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (150421475..150437430)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (148936742..148952697)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene zinc finger protein 398 Neighboring gene centrosomal protein 83kDa pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr7:148892414-148892735 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18752 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26812 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:148900065-148900565 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr7:148906433-148907147 Neighboring gene zinc finger protein 282 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:148916930-148917919 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:148923698-148923905 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:148930294-148931493 Neighboring gene Sharpr-MPRA regulatory region 80 Neighboring gene uncharacterized LOC124901769 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18753 Neighboring gene zinc finger protein 783 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:148978524-148979060 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18754 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:148982524-148982701 Neighboring gene AI894139 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and mapping of a novel human KRAB domain-containing C2H2-type zinc finger to chromosome 7q36.1. Becker KG, et al. Genomics, 1997 May 1. PMID 9169157
    2. Rapid isolation and characterization of 118 novel C2H2-type zinc finger cDNAs expressed in human brain. Becker KG, et al. Hum Mol Genet, 1995 Apr. PMID 7633419
    3. A protein-protein interaction network of transcription factors acting during liver cell proliferation. Gao J, et al. Genomics, 2008 Apr. PMID 18255255
    4. ZNF212 promotes genomic integrity through direct interaction with TRAIP. Chung HJ, et al. Nucleic Acids Res, 2023 Jan 25. PMID 36594163, Free PMC Article
    5. DULIP: A Dual Luminescence-Based Co-Immunoprecipitation Assay for Interactome Mapping in Mammalian Cells. Trepte P, et al. J Mol Biol, 2015 Oct 23. PMID 26264872

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZNF212 promotes genomic integrity through direct interaction with TRAIP.
      Title: ZNF212 promotes genomic integrity through direct interaction with TRAIP.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC9707

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dendrite development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in general adaptation syndrome, behavioral process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuromuscular process controlling balance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to alcohol IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in walking behavior IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 212
    Names
    Zinc finger protein C2H2-150

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012256.4 → NP_036388.2  zinc finger protein 212

      See identical proteins and their annotated locations for NP_036388.2

      Status: REVIEWED

      Source sequence(s)
      AK074821, BC022785
      Consensus CDS
      CCDS5896.1
      UniProtKB/Swiss-Prot
      B2RCF4, Q13396, Q8N664, Q9UDV6
      UniProtKB/TrEMBL
      A0A090N8N3, B3KQE6
      Related
      ENSP00000338572.2, ENST00000335870.7
      Conserved Domains (6) summary
      cd07765
      Location:142 → 180
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:367 → 479
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:371 → 391
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:318 → 338
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:429 → 449
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:441 → 466
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      149239651..149255606
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      150421475..150437430
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UDV6.3 GenPept UniProtKB/Swiss-Prot:Q9UDV6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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