krt5 keratin 5 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: krt5provided by ZNC
Official Full Name: keratin 5provided by ZNC
Primary source: ZFIN:ZDB-GENE-991110-23
See related: Ensembl:ENSDARG00000058371 AllianceGenome:ZFIN:ZDB-GENE-991110-23
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ckii; zfCKII; wu:fb02h09; wu:fj02d02; wu:fk78b12
Summary: Predicted to be a structural constituent of skin epidermis. Acts upstream of or within fin regeneration. Predicted to be located in intermediate filament. Predicted to be active in keratin filament. Is expressed in several structures, including EVL; epidermal cell; integument; oral region; and periderm. Human ortholog(s) of this gene implicated in several diseases, including Dowling-Degos disease; epidermolysis bullosa simplex (multiple); hypotrichosis (multiple); ichthyosis (multiple); and palmoplantar keratosis (multiple). Orthologous to several human genes including KRT5 (keratin 5) and KRT8 (keratin 8). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 23

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (10173198..10177442, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (10238228..10242505, complement)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

data show that a cis-element of the DNA segment in the CKII gene is required for epidermal cell-specific expression of CKII and that a minimal region upstream of the transcription start site is required for this expression restricted to epidermal cells
Title: Epidermis-restricted expression of zebrafish cytokeratin II is controlled by a -141/+85 minimal promoter, and cassette -141/-111 is essential for driving the tissue specificity.

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General gene information

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Markers

krt8 (e-PCR)
- UniSTS:205582

fk78b12.x1 (e-PCR)
- UniSTS:201531

fj02d02.x1 (e-PCR)
- UniSTS:198283

fc04g04.x1 (e-PCR)
- UniSTS:192175

fc04g04.x1 (e-PCR)
- UniSTS:192176

fb02h09.x1 (e-PCR)
- UniSTS:202687

ha2331 (e-PCR)
- UniSTS:515525

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables structural constituent of skin epidermis	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within fin regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in intermediate filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in keratinization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in intermediate filament	IEA Inferred from Electronic Annotation more info
is_active_in keratin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in keratin filament	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: keratin, type II cytoskeletal 5

Names: type II cytokeratin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131156.2 → NP_571231.2 keratin, type II cytoskeletal 5

Status: VALIDATED

Source sequence(s)

BC063955

UniProtKB/TrEMBL

A0A8M1PBF5, A0A8M6YXS6, F1QV31

Related

ENSDARP00000108711.2, ENSDART00000129044.4

Conserved Domains (2) summary

pfam00038
Location:156 → 467

Filament; Intermediate filament protein

pfam16208
Location:129 → 153

Keratin_2_head; Keratin type II head