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    Sh3bp5l SH3 binding domain protein 5 like [ Mus musculus (house mouse) ]

    Gene ID: 79566, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Sh3bp5lprovided by MGI
    Official Full Name
    SH3 binding domain protein 5 likeprovided by MGI
    Primary source
    MGI:MGI:1933124
    See related
    Ensembl:ENSMUSG00000013646 AllianceGenome:MGI:1933124
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1720; 2310074E09Rik
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and protein kinase inhibitor activity. Predicted to be involved in intracellular signal transduction. Predicted to be active in cytoplasm. Is expressed in cerebral cortex subventricular zone and cortical plate. Orthologous to human SH3BP5L (SH3 binding domain protein 5 like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 19.0), genital fat pad adult (RPKM 18.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sh3bp5l in Genome Data Viewer
    Location:
    11 B1.3; 11 36.19 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (58221533..58238554)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (58330707..58347728)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39827 Neighboring gene STARR-positive B cell enhancer ABC_E2989 Neighboring gene nuclear encoded tRNA leucine 3 (anticodon CAA) Neighboring gene zinc finger protein 692 Neighboring gene STARR-positive B cell enhancer ABC_E3953 Neighboring gene zinc finger protein 672 Neighboring gene predicted gene, 33660 Neighboring gene LY6/PLAUR domain containing 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
    2. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

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    Homology

    Clone Names

    • MGC7813

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein kinase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SH3 domain-binding protein 5-like
    Names
    SH3BP-5-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161338.2 → NP_001154810.1  SH3 domain-binding protein 5-like isoform 1

      See identical proteins and their annotated locations for NP_001154810.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1-3 encode the same isoform (1).
      Source sequence(s)
      AI505691, BC094418, BY125606
      Consensus CDS
      CCDS24728.1
      UniProtKB/Swiss-Prot
      Q3UMF7, Q8BUC2, Q91YX6, Q99LH9
      UniProtKB/TrEMBL
      Q80TA2
      Related
      ENSMUSP00000112077.3, ENSMUST00000116376.9
      Conserved Domains (1) summary
      pfam05276
      Location:54 → 282
      SH3BP5; SH3 domain-binding protein 5 (SH3BP5)

    2. NM_001308167.1 → NP_001295096.1  SH3 domain-binding protein 5-like isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 3. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AI505691, AK150129, BY125606
      UniProtKB/TrEMBL
      Q80TA2
      Conserved Domains (1) summary
      pfam05276
      Location:54 → 280
      SH3BP5; SH3 domain-binding protein 5 (SH3BP5)

    3. NM_001308168.1 → NP_001295097.1  SH3 domain-binding protein 5-like isoform 1

      See identical proteins and their annotated locations for NP_001295097.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript. Variants 1-3 encode the same isoform (1).
      Source sequence(s)
      AI505691, AK167203, BC094418, CJ153287
      Consensus CDS
      CCDS24728.1
      UniProtKB/Swiss-Prot
      Q3UMF7, Q8BUC2, Q91YX6, Q99LH9
      UniProtKB/TrEMBL
      Q80TA2
      Conserved Domains (1) summary
      pfam05276
      Location:54 → 282
      SH3BP5; SH3 domain-binding protein 5 (SH3BP5)

    4. NM_024480.5 → NP_077800.3  SH3 domain-binding protein 5-like isoform 1

      See identical proteins and their annotated locations for NP_077800.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 1-3 encode the same isoform (1).
      Source sequence(s)
      AI505691, AK159202, AK167203, BC094418, BY125606
      Consensus CDS
      CCDS24728.1
      UniProtKB/Swiss-Prot
      Q3UMF7, Q8BUC2, Q91YX6, Q99LH9
      UniProtKB/TrEMBL
      Q80TA2
      Related
      ENSMUSP00000072872.7, ENSMUST00000073128.7
      Conserved Domains (1) summary
      pfam05276
      Location:54 → 282
      SH3BP5; SH3 domain-binding protein 5 (SH3BP5)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      58221533..58238554
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534523.2 → XP_006534586.1  SH3 domain-binding protein 5-like isoform X1

      See identical proteins and their annotated locations for XP_006534586.1

      UniProtKB/Swiss-Prot
      Q3UMF7, Q8BUC2, Q91YX6, Q99LH9
      UniProtKB/TrEMBL
      Q80TA2
      Conserved Domains (1) summary
      pfam05276
      Location:54 → 282
      SH3BP5; SH3 domain-binding protein 5 (SH3BP5)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99LH9.1 GenPept UniProtKB/Swiss-Prot:Q99LH9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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