Serpind1 serpin family D member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Serpind1provided by RGD
Official Full Name: serpin family D member 1provided by RGD
Primary source: RGD:619854
See related: EnsemblRapid:ENSRNOG00000001865 AllianceGenome:RGD:619854
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: rls2var1
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in heparin cofactor II deficiency. Orthologous to human SERPIND1 (serpin family D member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 3375.1) See more
Orthologs: human mouse all
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Genomic context

Location:: 11q23

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (97168753..97179830, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (83664517..83675593, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (87913814..87924880, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D11Wox17 (e-PCR)
- UniSTS:519004

RH130116 (e-PCR)
- UniSTS:213404

MHAa22f12.seq (e-PCR)
- UniSTS:125096

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase inhibitor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in blood coagulation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: heparin cofactor 2

Names: HC-II; heparin cofactor II; leuserpin 2; protease inhibitor leuserpin-2; serine (or cysteine) peptidase inhibitor, clade D, member 1; serine (or cysteine) proteinase inhibitor, clade D, member 1; serpin D1; serpin peptidase inhibitor, clade D (heparin cofactor), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024382.1 → NP_077358.1 heparin cofactor 2 precursor

See identical proteins and their annotated locations for NP_077358.1

Status: PROVISIONAL

Source sequence(s)

X74549

UniProtKB/Swiss-Prot

Q5BKA6, Q64268

UniProtKB/TrEMBL

A0A0G2K8K3, A6JSM3

Related

ENSRNOP00000031829.4, ENSRNOT00000031819.7

Conserved Domains (1) summary

cd02047
Location:44 → 477

HCII; Heparin cofactor II (HCII) inhibits thrombin, the final protease of the coagulation cascade. HCII is allosterically activated by binding to cell surface glycosaminoglycans (GAGs). The specificity of HCII for thrombin is conferred by a highly acidic ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

97168753..97179830 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006248709.4 → XP_006248771.1 heparin cofactor 2 isoform X1

See identical proteins and their annotated locations for XP_006248771.1

UniProtKB/Swiss-Prot

Q5BKA6, Q64268

UniProtKB/TrEMBL

A0A0G2K8K3, A6JSM3

Related

ENSRNOP00000074639.2, ENSRNOT00000084973.3

Conserved Domains (1) summary

cd02047
Location:44 → 477

HCII; Heparin cofactor II (HCII) inhibits thrombin, the final protease of the coagulation cascade. HCII is allosterically activated by binding to cell surface glycosaminoglycans (GAGs). The specificity of HCII for thrombin is conferred by a highly acidic ...