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    Apol7a apolipoprotein L 7a [ Mus musculus (house mouse) ]

    Gene ID: 75761, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Apol7aprovided by MGI
    Official Full Name
    apolipoprotein L 7aprovided by MGI
    Primary source
    MGI:MGI:1923011
    See related
    Ensembl:ENSMUSG00000010601 AllianceGenome:MGI:1923011
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Apol3; 9130022K13Rik
    Summary
    Predicted to enable lipid binding activity. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human APOL2 (apolipoprotein L2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver adult (RPKM 21.3), large intestine adult (RPKM 17.0) and 6 other tissues See more
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    Genomic context

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    See Apol7a in Genome Data Viewer
    Location:
    15 D3; 15 36.4 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (77272417..77283310, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (77388217..77399110, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene 3787 Neighboring gene predicted gene, 53900 Neighboring gene predicted gene, 41353 Neighboring gene apolipoprotein L 9a Neighboring gene predicted gene, 36194 Neighboring gene apolipoprotein L 7b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    apolipoprotein L 7a
    Names
    apolipoprotein L 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164640.1 → NP_001158112.1  apolipoprotein L 7a

      See identical proteins and their annotated locations for NP_001158112.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK018646, AK085956, AL772386, BC139138
      Consensus CDS
      CCDS37125.1
      UniProtKB/TrEMBL
      B2RT54, E9Q635, Q9D2Y0
      Related
      ENSMUSP00000135864.2, ENSMUST00000175919.8
      Conserved Domains (1) summary
      pfam05461
      Location:22 → 416
      ApoL; Apolipoprotein L

    2. NM_029419.2 → NP_083695.2  apolipoprotein L 7a

      See identical proteins and their annotated locations for NP_083695.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AK018646, AL772386, BC139138
      Consensus CDS
      CCDS37125.1
      UniProtKB/TrEMBL
      B2RT54, E9Q635, Q9D2Y0
      Related
      ENSMUSP00000134864.2, ENSMUST00000176074.9
      Conserved Domains (1) summary
      pfam05461
      Location:22 → 416
      ApoL; Apolipoprotein L

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      77272417..77283310 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245766.1 → XP_011244068.1  apolipoprotein L 7a isoform X1

      See identical proteins and their annotated locations for XP_011244068.1

      UniProtKB/TrEMBL
      B2RT54, E9Q635, Q9D2Y0
      Conserved Domains (1) summary
      pfam05461
      Location:22 → 416
      ApoL; Apolipoprotein L
    Nucleotide Protein Strain
    Heading Accession and Version

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