Mpp7 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mpp7provided by MGI
Official Full Name: membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)provided by MGI
Primary source: MGI:MGI:1922989
See related: Ensembl:ENSMUSG00000057440 AllianceGenome:MGI:1922989
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm955; 1110068J02Rik; 2810038M04Rik; 5430426E14Rik
Summary: Predicted to enable molecular adaptor activity and protein domain specific binding activity. Predicted to be involved in bicellular tight junction assembly; positive regulation of protein-containing complex assembly; and protein localization to adherens junction. Predicted to be located in adherens junction; bicellular tight junction; and nucleoplasm. Predicted to be part of MPP7-DLG1-LIN7 complex. Predicted to be active in cell-cell junction and plasma membrane. Orthologous to human MPP7 (MAGUK p55 scaffold protein 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in bladder adult (RPKM 2.7), cerebellum adult (RPKM 1.8) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 A1; 18 4.53 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (7347962..7627017, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (7347962..7626889, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MPP7 as a novel candidate gene for Primary open angle glaucoma.
Title: Genetic association and stress mediated down-regulation in trabecular meshwork implicates MPP7 as a novel candidate gene in primary open angle glaucoma.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D18Mit168 (e-PCR), detects polymorphism
- UniSTS:128188

AI415104 (e-PCR)
- UniSTS:160710

NoName (e-PCR)
- UniSTS:488931

NoName (e-PCR)
- UniSTS:225004

D5Mit392.1 (e-PCR), detects polymorphism
- UniSTS:130544

UniSTS:236019 (e-PCR)
- UniSTS:236019

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein domain specific binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in bicellular tight junction assembly	ISO Inferred from Sequence Orthology more info
involved_in bicellular tight junction assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein-containing complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to adherens junction	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to adherens junction	ISO Inferred from Sequence Orthology more info
involved_in protein localization to adherens junction	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of MPP7-DLG1-LIN7 complex	ISO Inferred from Sequence Orthology more info
part_of MPP7-DLG1-LIN7 complex	ISS Inferred from Sequence or Structural Similarity more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in adherens junction	ISS Inferred from Sequence or Structural Similarity more info
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
located_in bicellular tight junction	ISS Inferred from Sequence or Structural Similarity more info
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
is_active_in cell-cell junction	IBA Inferred from Biological aspect of Ancestor more info
located_in lateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: MAGUK p55 subfamily member 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081287.2 → NP_001074756.2 MAGUK p55 subfamily member 7 isoform 1

See identical proteins and their annotated locations for NP_001074756.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Both variants 1 and 3 encode the same protein.

Source sequence(s)

AC138529, AK027937, AK078849, AV260217, CN457430

Consensus CDS

CCDS50217.1

UniProtKB/Swiss-Prot

Q148N6, Q8BVD5, Q8BZZ8, Q9D3K2

UniProtKB/TrEMBL

G5E8S8

Related

ENSMUSP00000111535.3, ENSMUST00000115869.4

Conserved Domains (4) summary

smart00569
Location:16 → 68

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12033
Location:232 → 292

SH3_MPP7; Src Homology 3 domain of Membrane Protein, Palmitoylated 7 (or MAGUK p55 subfamily member 7)

smart00072
Location:378 → 563

GuKc; Guanylate kinase homologues

cd00992
Location:137 → 217

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_001161620.1 → NP_001155092.1 MAGUK p55 subfamily member 7 isoform 2

See identical proteins and their annotated locations for NP_001155092.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 3. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 3.

Source sequence(s)

AK027937, AK078849

Consensus CDS

CCDS89187.1

UniProtKB/TrEMBL

A0A3Q4EGM2

Related

ENSMUSP00000157306.2, ENSMUST00000234571.2

Conserved Domains (3) summary

smart00569
Location:16 → 68

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12033
Location:232 → 292

SH3_MPP7; Src Homology 3 domain of Membrane Protein, Palmitoylated 7 (or MAGUK p55 subfamily member 7)

cd00992
Location:137 → 217

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_001360860.1 → NP_001347789.1 MAGUK p55 subfamily member 7 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (3) represents the longest transcript. Both variants 1 and 3 encode the same protein.

Source sequence(s)

AC138529, AC139157, AC139324

Consensus CDS

CCDS50217.1

UniProtKB/Swiss-Prot

Q148N6, Q8BVD5, Q8BZZ8, Q9D3K2

UniProtKB/TrEMBL

G5E8S8

Conserved Domains (4) summary

smart00569
Location:16 → 68

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12033
Location:232 → 292

SH3_MPP7; Src Homology 3 domain of Membrane Protein, Palmitoylated 7 (or MAGUK p55 subfamily member 7)

smart00072
Location:378 → 563

GuKc; Guanylate kinase homologues

cd00992
Location:137 → 217

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

7347962..7627017 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006526326.5 → XP_006526389.1 MAGUK p55 subfamily member 7 isoform X3

See identical proteins and their annotated locations for XP_006526389.1

UniProtKB/Swiss-Prot

Q148N6, Q8BVD5, Q8BZZ8, Q9D3K2

UniProtKB/TrEMBL

G5E8S8

Conserved Domains (4) summary

smart00569
Location:16 → 68

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12033
Location:232 → 292

SH3_MPP7; Src Homology 3 domain of Membrane Protein, Palmitoylated 7 (or MAGUK p55 subfamily member 7)

smart00072
Location:378 → 563

GuKc; Guanylate kinase homologues

cd00992
Location:137 → 217

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_006526325.5 → XP_006526388.1 MAGUK p55 subfamily member 7 isoform X2

UniProtKB/Swiss-Prot

Q148N6, Q8BVD5, Q8BZZ8, Q9D3K2

Conserved Domains (4) summary

smart00569
Location:16 → 68

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12033
Location:232 → 292

SH3_MPP7; Src Homology 3 domain of Membrane Protein, Palmitoylated 7 (or MAGUK p55 subfamily member 7)

smart00072
Location:402 → 587

GuKc; Guanylate kinase homologues

cd00992
Location:137 → 217

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_006526327.4 → XP_006526390.1 MAGUK p55 subfamily member 7 isoform X4

UniProtKB/Swiss-Prot

Q148N6, Q8BVD5, Q8BZZ8, Q9D3K2

Conserved Domains (4) summary

smart00569
Location:16 → 68

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12033
Location:232 → 292

SH3_MPP7; Src Homology 3 domain of Membrane Protein, Palmitoylated 7 (or MAGUK p55 subfamily member 7)

smart00072
Location:386 → 561

GuKc; Guanylate kinase homologues

cd00992
Location:137 → 217

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_011247025.4 → XP_011245327.1 MAGUK p55 subfamily member 7 isoform X1

See identical proteins and their annotated locations for XP_011245327.1

UniProtKB/Swiss-Prot

Q148N6, Q8BVD5, Q8BZZ8, Q9D3K2

Conserved Domains (4) summary

smart00569
Location:16 → 68

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12033
Location:232 → 292

SH3_MPP7; Src Homology 3 domain of Membrane Protein, Palmitoylated 7 (or MAGUK p55 subfamily member 7)

smart00072
Location:403 → 588

GuKc; Guanylate kinase homologues

cd00992
Location:137 → 217

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_017318006.3 → XP_017173495.1 MAGUK p55 subfamily member 7 isoform X1

UniProtKB/Swiss-Prot

Q148N6, Q8BVD5, Q8BZZ8, Q9D3K2

Conserved Domains (4) summary

smart00569
Location:16 → 68

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12033
Location:232 → 292

SH3_MPP7; Src Homology 3 domain of Membrane Protein, Palmitoylated 7 (or MAGUK p55 subfamily member 7)

smart00072
Location:403 → 588

GuKc; Guanylate kinase homologues

cd00992
Location:137 → 217

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_036161304.1 → XP_036017197.1 MAGUK p55 subfamily member 7 isoform X3

UniProtKB/Swiss-Prot

Q148N6, Q8BVD5, Q8BZZ8, Q9D3K2

UniProtKB/TrEMBL

G5E8S8

Conserved Domains (4) summary

smart00569
Location:16 → 68

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12033
Location:232 → 292

SH3_MPP7; Src Homology 3 domain of Membrane Protein, Palmitoylated 7 (or MAGUK p55 subfamily member 7)

smart00072
Location:378 → 563

GuKc; Guanylate kinase homologues

cd00992
Location:137 → 217

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_011247026.2 → XP_011245328.1 MAGUK p55 subfamily member 7 isoform X1

See identical proteins and their annotated locations for XP_011245328.1

UniProtKB/Swiss-Prot

Q148N6, Q8BVD5, Q8BZZ8, Q9D3K2

Conserved Domains (4) summary

smart00569
Location:16 → 68

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12033
Location:232 → 292

SH3_MPP7; Src Homology 3 domain of Membrane Protein, Palmitoylated 7 (or MAGUK p55 subfamily member 7)

smart00072
Location:403 → 588

GuKc; Guanylate kinase homologues

cd00992
Location:137 → 217

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_011247027.3 → XP_011245329.1 MAGUK p55 subfamily member 7 isoform X1

See identical proteins and their annotated locations for XP_011245329.1

UniProtKB/Swiss-Prot

Q148N6, Q8BVD5, Q8BZZ8, Q9D3K2

Conserved Domains (4) summary

smart00569
Location:16 → 68

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12033
Location:232 → 292

SH3_MPP7; Src Homology 3 domain of Membrane Protein, Palmitoylated 7 (or MAGUK p55 subfamily member 7)

smart00072
Location:403 → 588

GuKc; Guanylate kinase homologues

cd00992
Location:137 → 217

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_006526329.4 → XP_006526392.1 MAGUK p55 subfamily member 7 isoform X6

Conserved Domains (1) summary

smart00072
Location:165 → 350

GuKc; Guanylate kinase homologues
XM_017318008.2 → XP_017173497.1 MAGUK p55 subfamily member 7 isoform X5

Conserved Domains (1) summary

smart00072
Location:166 → 351

GuKc; Guanylate kinase homologues
XM_006526330.5 → XP_006526393.1 MAGUK p55 subfamily member 7 isoform X7

UniProtKB/TrEMBL

A0A3Q4EH71

Conserved Domains (3) summary

smart00569
Location:16 → 68

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12033
Location:232 → 292

SH3_MPP7; Src Homology 3 domain of Membrane Protein, Palmitoylated 7 (or MAGUK p55 subfamily member 7)

cd00992
Location:137 → 217

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_017318009.2 → XP_017173498.1 MAGUK p55 subfamily member 7 isoform X8

UniProtKB/TrEMBL

A0A3Q4EH71

Related

ENSMUSP00000157345.2, ENSMUST00000234812.2

Conserved Domains (3) summary

smart00569
Location:16 → 68

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12033
Location:232 → 292

SH3_MPP7; Src Homology 3 domain of Membrane Protein, Palmitoylated 7 (or MAGUK p55 subfamily member 7)

cd00992
Location:137 → 217

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_017318010.2 → XP_017173499.1 MAGUK p55 subfamily member 7 isoform X9

UniProtKB/TrEMBL

A0A3Q4EH71

Conserved Domains (3) summary

smart00569
Location:16 → 68

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12033
Location:232 → 292

SH3_MPP7; Src Homology 3 domain of Membrane Protein, Palmitoylated 7 (or MAGUK p55 subfamily member 7)

cd00992
Location:137 → 217

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...