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    Cylc2 cylicin, basic protein of sperm head cytoskeleton 2 [ Mus musculus (house mouse) ]

    Gene ID: 74914, updated on 12-Dec-2024

    Summary

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    Official Symbol
    Cylc2provided by MGI
    Official Full Name
    cylicin, basic protein of sperm head cytoskeleton 2provided by MGI
    Primary source
    MGI:MGI:1922164
    See related
    Ensembl:ENSMUSG00000039555 AllianceGenome:MGI:1922164
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930488P18Rik
    Summary
    Acts upstream of or within maintenance of cell number; single fertilization; and spermatogenesis. Orthologous to human CYLC2 (cylicin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 4.9) See more
    Orthologs
    human all
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    Genomic context

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    See Cylc2 in Genome Data Viewer
    Location:
    4 B1; 4 27.27 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (51216653..51250625)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (51216653..51250625)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 42288 Neighboring gene predicted gene, 42287 Neighboring gene STARR-seq mESC enhancer starr_10195 Neighboring gene STARR-seq mESC enhancer starr_10196 Neighboring gene predicted gene 12460 Neighboring gene STARR-seq mESC enhancer starr_10197 Neighboring gene S-adenosylmethionine decarboxylase, pseudogene 4 Neighboring gene STARR-seq mESC enhancer starr_10198 Neighboring gene predicted gene, 23043

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cylicins are a structural component of the sperm calyx being indispensable for male fertility in mice and human. Schneider S, et al. Elife, 2023 Nov 28. PMID 38013430, Free PMC Article
    2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within acrosome assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within cellular component organization or biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within maintenance of cell number IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within single fertilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    cylicin-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427180.1 → NP_001414109.1  cylicin-2

      Status: VALIDATED

      Source sequence(s)
      AL732569, AL772238
      Related
      ENSMUSP00000158665.2, ENSMUST00000156384.4

    2. NM_001427184.1 → NP_001414113.1  cylicin-2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL732569, AL772238
      Consensus CDS
      CCDS71386.1
      UniProtKB/Swiss-Prot
      A0A571BEE2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      51216653..51250625
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253866.1 → XP_030109726.1  cylicin-2 isoform X2

      Conserved Domains (2) summary
      PTZ00121
      Location:125 → 415
      PTZ00121; MAEBL; Provisional
      pfam15241
      Location:1 → 35
      Cylicin_N; Cylicin N-terminus

    2. XM_017320427.1 → XP_017175916.1  cylicin-2 isoform X1

      Conserved Domains (2) summary
      PTZ00121
      Location:200 → 490
      PTZ00121; MAEBL; Provisional
      pfam15241
      Location:8 → 110
      Cylicin_N; Cylicin N-terminus

    3. XM_017320426.1 → XP_017175915.1  cylicin-2 isoform X1

      Conserved Domains (2) summary
      PTZ00121
      Location:200 → 490
      PTZ00121; MAEBL; Provisional
      pfam15241
      Location:8 → 110
      Cylicin_N; Cylicin N-terminus

    4. XM_011250129.2 → XP_011248431.1  cylicin-2 isoform X3

      Conserved Domains (2) summary
      PTZ00121
      Location:82 → 360
      PTZ00121; MAEBL; Provisional
      pfam15241
      Location:8 → 110
      Cylicin_N; Cylicin N-terminus

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001162865.1: Suppressed sequence

      Description
      NM_001162865.1: This RefSeq was suppressed because it lacks polyA data, and hence 3' incomplete. RNA-seq and polyA-seq data suggest additional 3' UTR exons and several splice sites, so a new RefSeq (NM_001427184.1) was created.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A571BEE2.2 GenPept UniProtKB/Swiss-Prot:A0A571BEE2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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