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    Mterf2 mitochondrial transcription termination factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 74238, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mterf2provided by MGI
    Official Full Name
    mitochondrial transcription termination factor 2provided by MGI
    Primary source
    MGI:MGI:1921488
    See related
    Ensembl:ENSMUSG00000049038 AllianceGenome:MGI:1921488
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mterfd3; 1700007D05Rik
    Summary
    Predicted to enable DNA binding activity. Predicted to be involved in termination of mitochondrial transcription. Located in mitochondrial nucleoid. Orthologous to human MTERF2 (mitochondrial transcription termination factor 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 6.7), CNS E14 (RPKM 6.5) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mterf2 in Genome Data Viewer
    Location:
    10 C1; 10 41.63 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (84951092..84963982, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (85119433..85128027, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_27438 Neighboring gene predicted gene, 51826 Neighboring gene transmembrane protein 263 Neighboring gene four and a half LIM domains 4 Neighboring gene STARR-positive B cell enhancer ABC_E722 Neighboring gene cryptochrome circadian regulator 1 Neighboring gene STARR-seq mESC enhancer starr_27439 Neighboring gene STARR-seq mESC enhancer starr_27440 Neighboring gene predicted gene, 38575

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MTERF2 is a nucleoid component in mammalian mitochondria. Pellegrini M, et al. Biochim Biophys Acta, 2009 May. PMID 19366608
    2. The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes. Liu F, et al. Mol Cell Proteomics, 2018 Feb. PMID 29222160, Free PMC Article
    3. KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility. Gu J, et al. Cell Death Differ, 2023 Jul. PMID 37142655, Free PMC Article
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables double-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in termination of mitochondrial transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial nucleoid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transcription termination factor 2, mitochondrial
    Names
    MTERF domain containing 3
    mTERF domain-containing protein 3, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001379524.1 → NP_001366453.1  transcription termination factor 2, mitochondrial precursor

      Status: VALIDATED

      Source sequence(s)
      AC122238
      UniProtKB/Swiss-Prot
      Q8BKY8
      Conserved Domains (1) summary
      cl19765
      Location:58 → 360
      mTERF

    2. NM_001379525.1 → NP_001366454.1  transcription termination factor 2, mitochondrial precursor

      Status: VALIDATED

      Source sequence(s)
      AC122238
      UniProtKB/Swiss-Prot
      Q8BKY8
      Conserved Domains (1) summary
      cl19765
      Location:58 → 360
      mTERF

    3. NM_001379526.1 → NP_001366455.1  transcription termination factor 2, mitochondrial precursor

      Status: VALIDATED

      Source sequence(s)
      AC122238
      UniProtKB/Swiss-Prot
      Q8BKY8
      Conserved Domains (1) summary
      cl19765
      Location:58 → 360
      mTERF

    4. NM_028832.3 → NP_083108.1  transcription termination factor 2, mitochondrial precursor

      See identical proteins and their annotated locations for NP_083108.1

      Status: VALIDATED

      Source sequence(s)
      AA285696, AC122238, AK047778
      Consensus CDS
      CCDS24088.1
      UniProtKB/Swiss-Prot
      Q8BKY8
      Related
      ENSMUSP00000062762.3, ENSMUST00000050813.4
      Conserved Domains (1) summary
      cl19765
      Location:58 → 360
      mTERF

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      84951092..84963982 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245330.2 → XP_030101190.1  transcription termination factor 2, mitochondrial isoform X1

      Conserved Domains (1) summary
      cl19765
      Location:75 → 377
      mTERF
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BKY8.1 GenPept UniProtKB/Swiss-Prot:Q8BKY8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
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