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    murF UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [ Alistipes putredinis DSM 17216 ]

    Gene ID: 73804272, updated on 31-Mar-2024

    Summary

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    Gene symbol
    murF
    Gene description
    UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
    Locus tag
    ALIPUT_RS11845
    Gene type
    protein coding
    Organism
    Alistipes putredinis DSM 17216 (strain: DSM 17216, nat-host: Homo sapiens, type-material: type strain of Bacteroides putredinis)
    Lineage
    Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Rikenellaceae; Alistipes
    Old locus tag
    ALIPUT_01446
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    Genomic context

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    NZ_DS499581.1Genomic Context describing neighboring genes Neighboring gene LUD domain-containing protein Neighboring gene LUD domain-containing protein Neighboring gene mannose-1-phosphate guanylyltransferase Neighboring gene alpha/beta fold hydrolase Neighboring gene oligopeptide transporter, OPT family

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NZ_DS499581.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of MurF from Streptococcus pneumoniae co-crystallized with a small molecule inhibitor exhibits interdomain closure. Longenecker KL, et al. Protein Sci, 2005 Dec. PMID 16322581, Free PMC Article
    2. Mur Ligase Inhibitors as Anti-bacterials: A Comprehensive Review. Sangshetti JN, et al. Curr Pharm Des, 2017. PMID 28201974

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    General protein information

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    Preferred Names
    UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
    WP_040294008.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NZ_DS499581.1 Reference assembly

      Range
      207535..208794
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      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. WP_040294008.1 MULTISPECIES: UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [Alistipes]

      Conserved Domains (4) summary
      COG0770
      Location:13 → 419
      MurF; UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]
      pfam01225
      Location:14 → 88
      Mur_ligase; Mur ligase family, catalytic domain
      pfam02875
      Location:283 → 366
      Mur_ligase_C; Mur ligase family, glutamate ligase domain
      pfam08245
      Location:98 → 260
      Mur_ligase_M; Mur ligase middle domain

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