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    Coq2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase [ Mus musculus (house mouse) ]

    Gene ID: 71883, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Coq2provided by MGI
    Official Full Name
    coenzyme Q2 4-hydroxybenzoate polyprenyltransferaseprovided by MGI
    Primary source
    MGI:MGI:1919133
    See related
    Ensembl:ENSMUSG00000029319 AllianceGenome:MGI:1919133
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PHB:PPT; 2310002F18Rik
    Summary
    Predicted to enable 4-hydroxybenzoate polyprenyltransferase activity. Predicted to be involved in glycerol metabolic process and ubiquinone biosynthetic process. Located in mitochondrion. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and integumental system. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 1. Orthologous to human COQ2 (coenzyme Q2, polyprenyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 58.8), ovary adult (RPKM 49.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Coq2 in Genome Data Viewer
    Location:
    5 E4; 5 48.5 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (100802589..100822154, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (100654723..100674288, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene COP9 signalosome subunit 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:100998499-100998608 Neighboring gene placenta-specific 8 Neighboring gene STARR-positive B cell enhancer ABC_E11295 Neighboring gene STARR-positive B cell enhancer ABC_E11296 Neighboring gene STARR-positive B cell enhancer mm9_chr5:101027025-101027325 Neighboring gene STARR-positive B cell enhancer ABC_E9256 Neighboring gene STARR-positive B cell enhancer ABC_E8823 Neighboring gene STARR-seq mESC enhancer starr_13729 Neighboring gene heparanase Neighboring gene predicted gene, 36619

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. 4-Hydroxybenzoic acid rescues multisystemic disease and perinatal lethality in a mouse model of mitochondrial disease. Corral-Sarasa J, et al. Cell Rep, 2024 May 28. PMID 38697100
    2. Calorie restriction modifies ubiquinone and COQ transcript levels in mouse tissues. Parrado-Fernández C, et al. Free Radic Biol Med, 2011 Jun 15. PMID 21447381, Free PMC Article
    3. Global analysis of gene expression in the developing brain of Gtf2ird1 knockout mice. O'Leary J, et al. PLoS One, 2011. PMID 21909369, Free PMC Article
    4. The SRCAP chromatin remodeling complex promotes oxidative metabolism during prenatal heart development. Xu M, et al. Development, 2021 Apr 15. PMID 33913477
    5. Lack of periostin leads to suppression of Notch1 signaling and calcific aortic valve disease. Tkatchenko TV, et al. Physiol Genomics, 2009 Nov 6. PMID 19723774, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Calorie restriction modifies ubiquinone and COQ transcript levels in mouse tissues
      Title: Calorie restriction modifies ubiquinone and COQ transcript levels in mouse tissues.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC91278

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 4-hydroxybenzoate polyprenyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 4-hydroxybenzoate polyprenyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 4-hydroxybenzoate polyprenyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables prenyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycerol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycerol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in isoprenoid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquinone biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquinone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ubiquinone biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquinone biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquinone biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    4-hydroxybenzoate polyprenyltransferase, mitochondrial
    Names
    4-HB polyprenyltransferase
    PHB:polyprenyltransferase
    coenzyme Q2 homolog, prenyltransferase
    para-hydroxybenzoate--polyprenyltransferase, mitochondrial
    NP_082254.2
    XP_036021392.1
    XP_036021393.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027978.2 → NP_082254.2  4-hydroxybenzoate polyprenyltransferase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_082254.2

      Status: VALIDATED

      Source sequence(s)
      AK009092, CK626929
      Consensus CDS
      CCDS19465.1
      UniProtKB/Swiss-Prot
      E9QPH1, Q66JT7, Q9D7M9
      Related
      ENSMUSP00000031262.8, ENSMUST00000031262.9
      Conserved Domains (1) summary
      cl00337
      Location:68 → 352
      PT_UbiA; UbiA family of prenyltransferases (PTases)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      100802589..100822154 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165499.1 → XP_036021392.1  4-hydroxybenzoate polyprenyltransferase, mitochondrial isoform X1

      Conserved Domains (1) summary
      cl00337
      Location:97 → 265
      PT_UbiA; UbiA family of prenyltransferases (PTases)

    2. XM_036165500.1 → XP_036021393.1  4-hydroxybenzoate polyprenyltransferase, mitochondrial isoform X2

      Conserved Domains (1) summary
      cl00337
      Location:10 → 222
      PT_UbiA; UbiA family of prenyltransferases (PTases)

    RNA

    1. XR_389292.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q66JT7.2 GenPept UniProtKB/Swiss-Prot:Q66JT7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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