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    DEPDC5 DEP domain containing 5, GATOR1 subcomplex subunit [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 718522, updated on 5-Mar-2024

    Summary

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    Gene symbol
    DEPDC5
    Gene description
    DEP domain containing 5, GATOR1 subcomplex subunit
    Locus tag
    EGK_02963
    See related
    Ensembl:ENSMMUG00000021727
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See DEPDC5 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    47
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 10 NC_041763.1 (19594025..19758791, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 10 NC_027902.1 (73651141..73805354)

    Chromosome 10 - NC_041763.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene YWHAH antisense RNA 1 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta Neighboring gene U6 spliceosomal RNA Neighboring gene proline rich 14 like Neighboring gene phosphatidylserine decarboxylase Neighboring gene SFI1 centrin binding protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to amino acid starvation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of TORC1 signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of autophagy IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of GATOR1 complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GATOR complex protein DEPDC5
    Names
    DEP domain-containing protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041763.1 Reference Mmul_10 Primary Assembly

      Range
      19594025..19758791 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028827773.1 → XP_028683606.1  GATOR complex protein DEPDC5 isoform X1

      UniProtKB/TrEMBL
      F7E375
      Conserved Domains (2) summary
      cd04449
      Location:1187 → 1268
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:101 → 381
      IML1; Vacuolar membrane-associated protein Iml1

    2. XM_028827772.1 → XP_028683605.1  GATOR complex protein DEPDC5 isoform X1

      UniProtKB/TrEMBL
      F7E375
      Conserved Domains (2) summary
      cd04449
      Location:1187 → 1268
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:101 → 381
      IML1; Vacuolar membrane-associated protein Iml1

    3. XM_015150101.2 → XP_015005587.2  GATOR complex protein DEPDC5 isoform X13

      UniProtKB/TrEMBL
      A0A1D5QLB0
      Related
      ENSMMUP00000048835.2, ENSMMUT00000078425.2
      Conserved Domains (2) summary
      cd04449
      Location:1079 → 1160
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:101 → 381
      IML1; Vacuolar membrane-associated protein Iml1

    4. XM_028827781.1 → XP_028683614.1  GATOR complex protein DEPDC5 isoform X10

      UniProtKB/TrEMBL
      A0A1D5QLB0
      Conserved Domains (2) summary
      cd04449
      Location:1101 → 1182
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:101 → 381
      IML1; Vacuolar membrane-associated protein Iml1

    5. XM_028827777.1 → XP_028683610.1  GATOR complex protein DEPDC5 isoform X6

      UniProtKB/TrEMBL
      A0A1D5QFR9, F7E375
      Conserved Domains (2) summary
      cd04449
      Location:1157 → 1238
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:101 → 381
      IML1; Vacuolar membrane-associated protein Iml1

    6. XM_028827771.1 → XP_028683604.1  GATOR complex protein DEPDC5 isoform X1

      UniProtKB/TrEMBL
      F7E375
      Conserved Domains (2) summary
      cd04449
      Location:1187 → 1268
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:101 → 381
      IML1; Vacuolar membrane-associated protein Iml1

    7. XM_015150100.2 → XP_015005586.2  GATOR complex protein DEPDC5 isoform X12

      UniProtKB/TrEMBL
      A0A1D5QLB0
      Conserved Domains (2) summary
      cd04449
      Location:1092 → 1173
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:101 → 381
      IML1; Vacuolar membrane-associated protein Iml1

    8. XM_028827784.1 → XP_028683617.1  GATOR complex protein DEPDC5 isoform X15

      UniProtKB/TrEMBL
      F7E363
      Conserved Domains (2) summary
      cd04449
      Location:994 → 1075
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:101 → 381
      IML1; Vacuolar membrane-associated protein Iml1

    9. XM_028827782.1 → XP_028683615.1  GATOR complex protein DEPDC5 isoform X11

      UniProtKB/TrEMBL
      A0A1D5QLB0
      Conserved Domains (2) summary
      cd04449
      Location:1100 → 1181
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:101 → 381
      IML1; Vacuolar membrane-associated protein Iml1

    10. XM_028827780.1 → XP_028683613.1  GATOR complex protein DEPDC5 isoform X9

      UniProtKB/TrEMBL
      A0A1D5QLB0
      Conserved Domains (2) summary
      cd04449
      Location:1109 → 1190
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:101 → 381
      IML1; Vacuolar membrane-associated protein Iml1

    11. XM_028827783.1 → XP_028683616.1  GATOR complex protein DEPDC5 isoform X14

      UniProtKB/TrEMBL
      F7E363
      Related
      ENSMMUP00000028614.4, ENSMMUT00000030574.4
      Conserved Domains (2) summary
      cd04449
      Location:1072 → 1153
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:101 → 381
      IML1; Vacuolar membrane-associated protein Iml1

    12. XM_028827778.1 → XP_028683611.1  GATOR complex protein DEPDC5 isoform X7

      UniProtKB/TrEMBL
      F7E375
      Conserved Domains (2) summary
      cd04449
      Location:1156 → 1237
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:101 → 381
      IML1; Vacuolar membrane-associated protein Iml1

    13. XM_028827774.1 → XP_028683607.1  GATOR complex protein DEPDC5 isoform X3

      UniProtKB/TrEMBL
      F7E375
      Conserved Domains (2) summary
      cd04449
      Location:1178 → 1259
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:101 → 381
      IML1; Vacuolar membrane-associated protein Iml1

    14. XM_028827776.1 → XP_028683609.1  GATOR complex protein DEPDC5 isoform X5

      UniProtKB/TrEMBL
      F7E375
      Conserved Domains (2) summary
      cd04449
      Location:1165 → 1246
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:101 → 381
      IML1; Vacuolar membrane-associated protein Iml1

    15. XM_028827770.1 → XP_028683603.1  GATOR complex protein DEPDC5 isoform X1

      UniProtKB/TrEMBL
      F7E375
      Conserved Domains (2) summary
      cd04449
      Location:1187 → 1268
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:101 → 381
      IML1; Vacuolar membrane-associated protein Iml1

    16. XM_028827779.1 → XP_028683612.1  GATOR complex protein DEPDC5 isoform X8

      UniProtKB/TrEMBL
      A0A5F7ZCR6, F7E375
      Related
      ENSMMUP00000063376.1, ENSMMUT00000096163.1
      Conserved Domains (2) summary
      cd04449
      Location:1148 → 1229
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:101 → 381
      IML1; Vacuolar membrane-associated protein Iml1

    17. XM_028827775.1 → XP_028683608.1  GATOR complex protein DEPDC5 isoform X4

      UniProtKB/TrEMBL
      F7E375
      Conserved Domains (2) summary
      cd04449
      Location:1170 → 1251
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:101 → 381
      IML1; Vacuolar membrane-associated protein Iml1

    18. XM_015150094.2 → XP_015005580.2  GATOR complex protein DEPDC5 isoform X2

      UniProtKB/TrEMBL
      A0A1D5QIJ7, F7E375
      Conserved Domains (2) summary
      cd04449
      Location:1179 → 1260
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:101 → 381
      IML1; Vacuolar membrane-associated protein Iml1

    19. XM_015150099.2 → XP_015005585.2  GATOR complex protein DEPDC5 isoform X10

      UniProtKB/TrEMBL
      A0A1D5QLB0
      Conserved Domains (2) summary
      cd04449
      Location:1101 → 1182
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:101 → 381
      IML1; Vacuolar membrane-associated protein Iml1

    20. XM_015150096.2 → XP_015005582.2  GATOR complex protein DEPDC5 isoform X6

      UniProtKB/TrEMBL
      A0A1D5QFR9, F7E375
      Related
      ENSMMUP00000046889.2, ENSMMUT00000067839.2
      Conserved Domains (2) summary
      cd04449
      Location:1157 → 1238
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:101 → 381
      IML1; Vacuolar membrane-associated protein Iml1

    21. XM_015150093.2 → XP_015005579.2  GATOR complex protein DEPDC5 isoform X2

      UniProtKB/TrEMBL
      A0A1D5QIJ7, F7E375
      Related
      ENSMMUP00000047869.2, ENSMMUT00000059850.2
      Conserved Domains (2) summary
      cd04449
      Location:1179 → 1260
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:101 → 381
      IML1; Vacuolar membrane-associated protein Iml1

    RNA

    1. XR_003719907.1 RNA Sequence

    2. XR_003719908.1 RNA Sequence

    3. XR_001447745.2 RNA Sequence

    4. XR_003719909.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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