Lrrc34 leucine rich repeat containing 34 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lrrc34provided by MGI
Official Full Name: leucine rich repeat containing 34provided by MGI
Primary source: MGI:MGI:1919077
See related: Ensembl:ENSMUSG00000027702 AllianceGenome:MGI:1919077
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SPATA34; 1700007J06Rik
Summary: Predicted to be involved in cell differentiation. Predicted to be located in cytoplasm and nucleolus. Is expressed in lateral ventricle choroid plexus and reproductive system. Orthologous to human LRRC34 (leucine rich repeat containing 34). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward testis adult (RPKM 25.3) See more
Orthologs: human all
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Genomic context

Location:: 3 A3; 3 14.27 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (30678416..30701967, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (30624267..30647818, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lrrc34 Interacts with Oct4 and Has an Impact on Telomere Length in Mouse Embryonic Stem Cells.
Title: Lrrc34 Interacts with Oct4 and Has an Impact on Telomere Length in Mouse Embryonic Stem Cells.
Lrrc34 Is Highly Expressed in SSCs and Is Necessary for SSC Expansion In Vitro.
Title: Lrrc34 Is Highly Expressed in SSCs and Is Necessary for SSC Expansion In Vitro.
Authors found that the Spata34 gene KO mice had normal fertility compared with wild type mice, and no overt detectable difference was found in testis/body weight ratios, testicular histology, sperm counts and spermatozoa motility parameters between WT and Spata34 KO mice.
Title: The testis-specific expressed gene Spata34 is not required for fertility in mice.
LRRC34 is a novel nucleolar protein that is predominantly expressed in pluripotent stem cells.
Title: Lrrc34, a novel nucleolar protein, interacts with npm1 and ncl and has an impact on pluripotent stem cells.
Overexpression of Spata34 in COS7 cells inhibited the transcriptional activity of AP-1, p53 and p21 which suggested that Spata34 protein may act as a transcriptional repressor in p53 and p21 pathway
Title: Expression and identification of a novel gene Spata34 in mouse spermatogenic cells.
Lrrc34 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.
Title: Tissue expression patterns identify mouse cilia genes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: leucine-rich repeat-containing protein 34

Names: spermatogenesis associated SPATA34

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027941.1 → NP_082217.1 leucine-rich repeat-containing protein 34

See identical proteins and their annotated locations for NP_082217.1

Status: PROVISIONAL

Source sequence(s)

BC100519

Consensus CDS

CCDS38405.1

UniProtKB/Swiss-Prot

A0AUN5, Q14B04, Q9DAM1

Related

ENSMUSP00000029252.8, ENSMUST00000029252.8

Conserved Domains (3) summary

cd00116
Location:70 → 347

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:79 → 103

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:245 → 314

LRR_8; Leucine rich repeat