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    RYR2 ryanodine receptor 2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 717179, updated on 17-Aug-2024

    Summary

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    Official Symbol
    RYR2provided by VGNC
    Official Full Name
    ryanodine receptor 2provided by VGNC
    Primary source
    VGNC:VGNC:76954
    See related
    Ensembl:ENSMMUG00000001060
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See RYR2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    109
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 1 NC_041754.1 (11227606..12012016, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 1 NC_027893.1 (213408788..214208736)

    Chromosome 1 - NC_041754.1Genomic Context describing neighboring genes Neighboring gene actin-like Neighboring gene zona pellucida glycoprotein 4 Neighboring gene uncharacterized LOC114678773 Neighboring gene uncharacterized LOC114678776 Neighboring gene uncharacterized LOC106995169 Neighboring gene 5-methyltetrahydrofolate-homocysteine methyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ryanodine-sensitive calcium-release channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Z disc IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of calcium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in sarcolemma IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in sarcoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in smooth endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ryanodine receptor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041754.1 Reference Mmul_10 Primary Assembly

      Range
      11227606..12012016 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015126674.2 → XP_014982160.1  ryanodine receptor 2 isoform X11

      Conserved Domains (13) summary
      smart00472
      Location:286 → 376
      MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
      cd12877
      Location:654 → 805
      SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
      cd12878
      Location:1085 → 1217
      SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
      pfam00520
      Location:4748 → 4908
      Ion_trans; Ion transport protein
      pfam01365
      Location:455 → 643
      RYDR_ITPR; RIH domain
      pfam02026
      Location:2700 → 2790
      RyR; RyR domain
      pfam02815
      Location:226 → 406
      MIR; MIR domain
      pfam06459
      Location:4363 → 4629
      RR_TM4-6; Ryanodine Receptor TM 4-6
      pfam08454
      Location:3865 → 3978
      RIH_assoc; RyR and IP3R Homology associated
      pfam13499
      Location:4060 → 4117
      EF-hand_7; EF-hand domain pair
      cd12879
      Location:1411 → 1557
      SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
      cl08302
      Location:4060 → 4115
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl19745
      Location:9 → 216
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

    2. XM_015126668.2 → XP_014982154.1  ryanodine receptor 2 isoform X10

      UniProtKB/TrEMBL
      F6QN38
      Related
      ENSMMUP00000001421.4, ENSMMUT00000001510.4
      Conserved Domains (13) summary
      smart00472
      Location:286 → 376
      MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
      cd12877
      Location:654 → 805
      SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
      cd12878
      Location:1086 → 1218
      SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
      pfam00520
      Location:4718 → 4878
      Ion_trans; Ion transport protein
      pfam01365
      Location:455 → 643
      RYDR_ITPR; RIH domain
      pfam02026
      Location:2701 → 2791
      RyR; RyR domain
      pfam02815
      Location:226 → 406
      MIR; MIR domain
      pfam06459
      Location:4333 → 4599
      RR_TM4-6; Ryanodine Receptor TM 4-6
      pfam08454
      Location:3835 → 3948
      RIH_assoc; RyR and IP3R Homology associated
      pfam13499
      Location:4030 → 4087
      EF-hand_7; EF-hand domain pair
      cd12879
      Location:1412 → 1558
      SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
      cl08302
      Location:4030 → 4085
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl19745
      Location:9 → 216
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

    3. XM_015126664.2 → XP_014982150.1  ryanodine receptor 2 isoform X9

      Conserved Domains (13) summary
      smart00472
      Location:286 → 376
      MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
      cd12877
      Location:654 → 805
      SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
      cd12878
      Location:1086 → 1218
      SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
      pfam00520
      Location:4726 → 4886
      Ion_trans; Ion transport protein
      pfam01365
      Location:455 → 643
      RYDR_ITPR; RIH domain
      pfam02026
      Location:2701 → 2791
      RyR; RyR domain
      pfam02815
      Location:226 → 406
      MIR; MIR domain
      pfam06459
      Location:4341 → 4607
      RR_TM4-6; Ryanodine Receptor TM 4-6
      pfam08454
      Location:3843 → 3956
      RIH_assoc; RyR and IP3R Homology associated
      pfam13499
      Location:4038 → 4095
      EF-hand_7; EF-hand domain pair
      cd12879
      Location:1412 → 1558
      SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
      cl08302
      Location:4038 → 4093
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl19745
      Location:9 → 216
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

    4. XM_015126607.2 → XP_014982093.1  ryanodine receptor 2 isoform X1

      Conserved Domains (13) summary
      smart00472
      Location:286 → 376
      MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
      cd12877
      Location:654 → 805
      SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
      cd12878
      Location:1086 → 1218
      SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
      pfam00520
      Location:4779 → 4939
      Ion_trans; Ion transport protein
      pfam01365
      Location:455 → 643
      RYDR_ITPR; RIH domain
      pfam02026
      Location:2711 → 2801
      RyR; RyR domain
      pfam02815
      Location:226 → 406
      MIR; MIR domain
      pfam06459
      Location:4394 → 4660
      RR_TM4-6; Ryanodine Receptor TM 4-6
      pfam08454
      Location:3896 → 4009
      RIH_assoc; RyR and IP3R Homology associated
      pfam13499
      Location:4091 → 4148
      EF-hand_7; EF-hand domain pair
      cd12879
      Location:1412 → 1568
      SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
      cl08302
      Location:4091 → 4146
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl19745
      Location:9 → 216
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

    5. XM_015126658.2 → XP_014982144.1  ryanodine receptor 2 isoform X8

      Conserved Domains (13) summary
      smart00472
      Location:279 → 369
      MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
      cd12877
      Location:647 → 798
      SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
      cd12878
      Location:1079 → 1211
      SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
      pfam00520
      Location:4699 → 4859
      Ion_trans; Ion transport protein
      pfam01365
      Location:448 → 636
      RYDR_ITPR; RIH domain
      pfam02026
      Location:2694 → 2784
      RyR; RyR domain
      pfam02815
      Location:219 → 399
      MIR; MIR domain
      pfam06459
      Location:4314 → 4580
      RR_TM4-6; Ryanodine Receptor TM 4-6
      pfam08454
      Location:3816 → 3929
      RIH_assoc; RyR and IP3R Homology associated
      pfam13499
      Location:4011 → 4068
      EF-hand_7; EF-hand domain pair
      cd12879
      Location:1405 → 1551
      SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
      cl08302
      Location:4011 → 4066
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl19745
      Location:9 → 209
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

    6. XM_015126652.2 → XP_014982138.1  ryanodine receptor 2 isoform X7

      Conserved Domains (13) summary
      smart00472
      Location:279 → 369
      MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
      cd12877
      Location:647 → 798
      SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
      cd12878
      Location:1079 → 1211
      SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
      pfam00520
      Location:4707 → 4867
      Ion_trans; Ion transport protein
      pfam01365
      Location:448 → 636
      RYDR_ITPR; RIH domain
      pfam02026
      Location:2694 → 2784
      RyR; RyR domain
      pfam02815
      Location:219 → 399
      MIR; MIR domain
      pfam06459
      Location:4322 → 4588
      RR_TM4-6; Ryanodine Receptor TM 4-6
      pfam08454
      Location:3824 → 3937
      RIH_assoc; RyR and IP3R Homology associated
      pfam13499
      Location:4019 → 4076
      EF-hand_7; EF-hand domain pair
      cd12879
      Location:1405 → 1551
      SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
      cl08302
      Location:4019 → 4074
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl19745
      Location:9 → 209
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

    7. XM_015126634.2 → XP_014982120.1  ryanodine receptor 2 isoform X6

      Conserved Domains (13) summary
      smart00472
      Location:286 → 376
      MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
      cd12877
      Location:654 → 805
      SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
      cd12878
      Location:1086 → 1218
      SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
      pfam00520
      Location:4748 → 4908
      Ion_trans; Ion transport protein
      pfam01365
      Location:455 → 643
      RYDR_ITPR; RIH domain
      pfam02026
      Location:2711 → 2801
      RyR; RyR domain
      pfam02815
      Location:226 → 406
      MIR; MIR domain
      pfam06459
      Location:4363 → 4629
      RR_TM4-6; Ryanodine Receptor TM 4-6
      pfam08454
      Location:3865 → 3978
      RIH_assoc; RyR and IP3R Homology associated
      pfam13499
      Location:4060 → 4117
      EF-hand_7; EF-hand domain pair
      cd12879
      Location:1412 → 1568
      SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
      cl08302
      Location:4060 → 4115
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl19745
      Location:9 → 216
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

    8. XM_015126626.2 → XP_014982112.1  ryanodine receptor 2 isoform X5

      Conserved Domains (13) summary
      smart00472
      Location:286 → 376
      MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
      cd12877
      Location:654 → 805
      SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
      cd12878
      Location:1086 → 1218
      SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
      pfam00520
      Location:4759 → 4919
      Ion_trans; Ion transport protein
      pfam01365
      Location:455 → 643
      RYDR_ITPR; RIH domain
      pfam02026
      Location:2711 → 2801
      RyR; RyR domain
      pfam02815
      Location:226 → 406
      MIR; MIR domain
      pfam06459
      Location:4374 → 4640
      RR_TM4-6; Ryanodine Receptor TM 4-6
      pfam08454
      Location:3876 → 3989
      RIH_assoc; RyR and IP3R Homology associated
      pfam13499
      Location:4071 → 4128
      EF-hand_7; EF-hand domain pair
      cd12879
      Location:1412 → 1568
      SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
      cl08302
      Location:4071 → 4126
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl19745
      Location:9 → 216
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

    9. XM_015126613.2 → XP_014982099.1  ryanodine receptor 2 isoform X3

      Conserved Domains (13) summary
      smart00472
      Location:286 → 376
      MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
      cd12877
      Location:654 → 805
      SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
      cd12878
      Location:1086 → 1218
      SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
      pfam00520
      Location:4767 → 4927
      Ion_trans; Ion transport protein
      pfam01365
      Location:455 → 643
      RYDR_ITPR; RIH domain
      pfam02026
      Location:2711 → 2801
      RyR; RyR domain
      pfam02815
      Location:226 → 406
      MIR; MIR domain
      pfam06459
      Location:4382 → 4648
      RR_TM4-6; Ryanodine Receptor TM 4-6
      pfam08454
      Location:3884 → 3997
      RIH_assoc; RyR and IP3R Homology associated
      pfam13499
      Location:4079 → 4136
      EF-hand_7; EF-hand domain pair
      cd12879
      Location:1412 → 1568
      SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
      cl08302
      Location:4079 → 4134
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl19745
      Location:9 → 216
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

    10. XM_015126618.2 → XP_014982104.1  ryanodine receptor 2 isoform X4

      Conserved Domains (13) summary
      smart00472
      Location:286 → 376
      MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
      cd12877
      Location:654 → 805
      SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
      cd12878
      Location:1086 → 1218
      SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
      pfam00520
      Location:4760 → 4920
      Ion_trans; Ion transport protein
      pfam01365
      Location:455 → 643
      RYDR_ITPR; RIH domain
      pfam02026
      Location:2711 → 2801
      RyR; RyR domain
      pfam02815
      Location:226 → 406
      MIR; MIR domain
      pfam06459
      Location:4375 → 4641
      RR_TM4-6; Ryanodine Receptor TM 4-6
      pfam08454
      Location:3877 → 3990
      RIH_assoc; RyR and IP3R Homology associated
      pfam13499
      Location:4072 → 4129
      EF-hand_7; EF-hand domain pair
      cd12879
      Location:1412 → 1568
      SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
      cl08302
      Location:4072 → 4127
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl19745
      Location:9 → 216
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

    11. XM_015126609.2 → XP_014982095.1  ryanodine receptor 2 isoform X2

      Conserved Domains (13) summary
      smart00472
      Location:286 → 376
      MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
      cd12877
      Location:654 → 805
      SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
      cd12878
      Location:1086 → 1218
      SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
      pfam00520
      Location:4768 → 4928
      Ion_trans; Ion transport protein
      pfam01365
      Location:455 → 643
      RYDR_ITPR; RIH domain
      pfam02026
      Location:2711 → 2801
      RyR; RyR domain
      pfam02815
      Location:226 → 406
      MIR; MIR domain
      pfam06459
      Location:4383 → 4649
      RR_TM4-6; Ryanodine Receptor TM 4-6
      pfam08454
      Location:3885 → 3998
      RIH_assoc; RyR and IP3R Homology associated
      pfam13499
      Location:4080 → 4137
      EF-hand_7; EF-hand domain pair
      cd12879
      Location:1412 → 1568
      SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
      cl08302
      Location:4080 → 4135
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl19745
      Location:9 → 216
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    Nucleotide Protein
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