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    SETD2 SET domain containing 2, histone lysine methyltransferase [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 711825, updated on 17-Aug-2024

    Summary

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    Official Symbol
    SETD2provided by VGNC
    Official Full Name
    SET domain containing 2, histone lysine methyltransferaseprovided by VGNC
    Primary source
    VGNC:VGNC:77269
    See related
    Ensembl:ENSMMUG00000021117
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See SETD2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 2 NC_041755.1 (103009809..103161428, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 2 NC_027894.1 (95405980..95516712)

    Chromosome 2 - NC_041755.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114676342 Neighboring gene neurobeachin like 2 Neighboring gene small nucleolar RNA U13 Neighboring gene kinesin family member 9 Neighboring gene kelch like family member 18 Neighboring gene protein tyrosine phosphatase non-receptor type 23

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables histone H3K36 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histone-lysine N-methyltransferase SETD2
    XP_028699892.1
    XP_028699893.1
    XP_028699894.1
    XP_028699895.1
    XP_028699896.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041755.1 Reference Mmul_10 Primary Assembly

      Range
      103009809..103161428 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028844063.1 → XP_028699896.1  histone-lysine N-methyltransferase SETD2 isoform X5

      UniProtKB/TrEMBL
      H9FTE9
      Conserved Domains (6) summary
      smart00570
      Location:1496 → 1550
      AWS; associated with SET domains
      smart00317
      Location:1551 → 1674
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:1675 → 1691
      PostSET; Cysteine-rich motif following a subset of SET domains
      TIGR01622
      Location:1707 → 1826
      SF-CC1; splicing factor, CC1-like family
      pfam08236
      Location:2163 → 2250
      SRI; SRI (Set2 Rpb1 interacting) domain
      pfam00397
      Location:2085 → 2114
      WW; WW domain

    2. XM_028844062.1 → XP_028699895.1  histone-lysine N-methyltransferase SETD2 isoform X4

      UniProtKB/TrEMBL
      H9FTE9
      Conserved Domains (5) summary
      smart00570
      Location:1496 → 1550
      AWS; associated with SET domains
      smart00317
      Location:1551 → 1674
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:1675 → 1691
      PostSET; Cysteine-rich motif following a subset of SET domains
      pfam08236
      Location:2164 → 2251
      SRI; SRI (Set2 Rpb1 interacting) domain
      pfam00397
      Location:2086 → 2115
      WW; WW domain

    3. XM_028844061.1 → XP_028699894.1  histone-lysine N-methyltransferase SETD2 isoform X3

      UniProtKB/TrEMBL
      A0A5F8ARP5, H9FTE9
      Related
      ENSMMUP00000080068.1, ENSMMUT00000100792.1
      Conserved Domains (6) summary
      pfam05279
      Location:1896 → 2079
      Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
      smart00570
      Location:1496 → 1550
      AWS; associated with SET domains
      smart00317
      Location:1551 → 1674
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:1675 → 1691
      PostSET; Cysteine-rich motif following a subset of SET domains
      pfam08236
      Location:2425 → 2512
      SRI; SRI (Set2 Rpb1 interacting) domain
      pfam00397
      Location:2347 → 2376
      WW; WW domain

    4. XM_028844060.1 → XP_028699893.1  histone-lysine N-methyltransferase SETD2 isoform X2

      UniProtKB/TrEMBL
      H9FTE9
      Conserved Domains (6) summary
      pfam05279
      Location:1941 → 2123
      Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
      smart00570
      Location:1496 → 1550
      AWS; associated with SET domains
      smart00317
      Location:1551 → 1674
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:1675 → 1691
      PostSET; Cysteine-rich motif following a subset of SET domains
      pfam08236
      Location:2469 → 2556
      SRI; SRI (Set2 Rpb1 interacting) domain
      pfam00397
      Location:2391 → 2420
      WW; WW domain

    5. XM_028844059.1 → XP_028699892.1  histone-lysine N-methyltransferase SETD2 isoform X1

      UniProtKB/TrEMBL
      F7HU62, H9FTE9
      Related
      ENSMMUP00000027795.4, ENSMMUT00000029698.4
      Conserved Domains (6) summary
      pfam05279
      Location:1941 → 2124
      Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
      smart00570
      Location:1496 → 1550
      AWS; associated with SET domains
      smart00317
      Location:1551 → 1674
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:1675 → 1691
      PostSET; Cysteine-rich motif following a subset of SET domains
      pfam08236
      Location:2470 → 2557
      SRI; SRI (Set2 Rpb1 interacting) domain
      pfam00397
      Location:2392 → 2421
      WW; WW domain

    RNA

    1. XR_003727278.1 RNA Sequence

    2. XR_003727277.1 RNA Sequence

    3. XR_003727279.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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