Pcgf6 polycomb group ring finger 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pcgf6provided by MGI
Official Full Name: polycomb group ring finger 6provided by MGI
Primary source: MGI:MGI:1918291
See related: Ensembl:ENSMUSG00000025050 AllianceGenome:MGI:1918291
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MBLR; Rnf134; 4933407A11Rik
Summary: Predicted to enable protein domain specific binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of PcG protein complex. Is expressed in central nervous system; eye; limb; trunk somite; and urinary system. Orthologous to human PCGF6 (polycomb group ring finger 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 18.0), whole brain E14.5 (RPKM 15.5) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C3; 19 39.11 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (47022056..47039379, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (47033617..47050939, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PCGF6 controls murine Tuft cell differentiation via H3K9me2 modification independently of Polycomb repression.
Title: PCGF6 controls murine Tuft cell differentiation via H3K9me2 modification independently of Polycomb repression.
Polycomb group ring finger protein 6 suppresses Myc-induced lymphomagenesis.
Title: Polycomb group ring finger protein 6 suppresses Myc-induced lymphomagenesis.
H2AK119ub1 guides maternal inheritance and zygotic deposition of H3K27me3 in mouse embryos.
Title: H2AK119ub1 guides maternal inheritance and zygotic deposition of H3K27me3 in mouse embryos.
The polycomb group protein PCGF6 mediates germline gene silencing by recruiting histone-modifying proteins to target gene promoters.
Title: The polycomb group protein PCGF6 mediates germline gene silencing by recruiting histone-modifying proteins to target gene promoters.
The authors findings highlight a novel mechanism of Pcgf6 protein in regulating stem cell pluripotency: PCGF6 is recruited to a subset of the super-enhancer (SE) regions upstream of cell cycle-associated genes by Oct4 (Octamer Transcription Factor-4) and increased their expression, also, PCGF6 activates cell cycle genes by regulating SE-promoter interactions via 3D chromatin.
Title: PCGF6 regulates stem cell pluripotency as a transcription activator via super-enhancer dependent chromatin interactions.
Pcgf6 acts as a master regulator to maintain embryonic stem cell identity.
Title: Polycomb Group Protein Pcgf6 Acts as a Master Regulator to Maintain Embryonic Stem Cell Identity.
Conditional ablation of Pcgf6 in embryonic stem cells leads to robust de-repression of germ cell-related genes, in turn affecting cell growth and viability.
Title: PCGF6-PRC1 suppresses premature differentiation of mouse embryonic stem cells by regulating germ cell-related genes.
The results identify two key regulators, PCGF6 and JARID1c that temper dendritic cells (DC) activation and implicate active transcriptional silencing via histone demethylation as a previously unappreciated mechanism for regulating DC activation and quiescence.
Title: The Transcriptional Repressor Polycomb Group Factor 6, PCGF6, Negatively Regulates Dendritic Cell Activation and Promotes Quiescence.
Pcgf6 is essential for recruitment of PRC1.6 to chromatin. Our results reveal a previously uncharacterized, H2AK119ub1-independent chromatin assembly associated with PRC1.6 complex
Title: Essential Role for Polycomb Group Protein Pcgf6 in Embryonic Stem Cell Maintenance and a Noncanonical Polycomb Repressive Complex 1 (PRC1) Integrity.
that Pcgf6 is nonredundantly involved in maintaining the pluripotent nature of embryonic stem cells and it functions in induced pluripotent stem reprogramming
Title: Pcgf6, a polycomb group protein, regulates mesodermal lineage differentiation in murine ESCs and functions in iPS reprogramming.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI604840 (e-PCR)
- UniSTS:164660

NoName (e-PCR)
- UniSTS:237966

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of PRC1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of PRC1 complex	ISO Inferred from Sequence Orthology more info
part_of PRC1 complex	ISS Inferred from Sequence or Structural Similarity more info
part_of PcG protein complex	IDA Inferred from Direct Assay more info	PubMed
part_of PcG protein complex	ISO Inferred from Sequence Orthology more info
part_of PcG protein complex	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: polycomb group RING finger protein 6

Names: Mel18- and Bmi1-like RING finger protein; ring finger protein 134

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001360632.1 → NP_001347561.1 polycomb group RING finger protein 6 isoform 2

Status: VALIDATED

Source sequence(s)

AC108814, BC089460

Conserved Domains (2) summary

pfam16207
Location:284 → 331

RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like

cd16738
Location:133 → 177

RING-HC_PCGF6; RING finger found in polycomb group RING finger protein 6 (PCGF6) and similar proteins
NM_027654.3 → NP_081930.1 polycomb group RING finger protein 6 isoform 1

See identical proteins and their annotated locations for NP_081930.1

Status: VALIDATED

Source sequence(s)

AC108814, BC089460

Consensus CDS

CCDS29885.1

UniProtKB/Swiss-Prot

Q99NA9

Related

ENSMUSP00000026032.6, ENSMUST00000026032.7

Conserved Domains (2) summary

pfam00097
Location:137 → 175

zf-C3HC4; Zinc finger, C3HC4 type (RING finger)

pfam16207
Location:266 → 322

RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like

RNA

NR_133574.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC108814, BC089460

Related

ENSMUST00000235633.2
NR_153762.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC108814, BC089460

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

47022056..47039379 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006527338.5 → XP_006527401.1 polycomb group RING finger protein 6 isoform X1

UniProtKB/TrEMBL

Q3V1H7

Conserved Domains (2) summary

cd16738
Location:133 → 177

RING-HC_PCGF6; RING finger found in polycomb group RING finger protein 6 (PCGF6) and similar proteins

cl28922
Location:255 → 313

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_030251075.1 → XP_030106935.1 polycomb group RING finger protein 6 isoform X2

UniProtKB/TrEMBL

Q3V1H7

Conserved Domains (2) summary

cd16738
Location:133 → 177

RING-HC_PCGF6; RING finger found in polycomb group RING finger protein 6 (PCGF6) and similar proteins

cd17085
Location:255 → 307

RAWUL_PCGF6; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 6 (PCGF6) and similar proteins
XM_036161687.1 → XP_036017580.1 polycomb group RING finger protein 6 isoform X3

UniProtKB/TrEMBL

A0A494B9Z3

Conserved Domains (1) summary

cd16738
Location:133 → 177

RING-HC_PCGF6; RING finger found in polycomb group RING finger protein 6 (PCGF6) and similar proteins