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    NFKB1 nuclear factor kappa B subunit 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 710324, updated on 17-Aug-2024

    Summary

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    Official Symbol
    NFKB1provided by VGNC
    Official Full Name
    nuclear factor kappa B subunit 1provided by VGNC
    Primary source
    VGNC:VGNC:75339
    Locus tag
    EGK_15972
    See related
    Ensembl:ENSMMUG00000003736
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See NFKB1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 5 NC_041758.1 (100887542..101010961)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 5 NC_027897.1 (101330818..101454505)

    Chromosome 5 - NC_041758.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 39 member 8 Neighboring gene zinc finger protein 705A pseudogene Neighboring gene protein argonaute 14 Neighboring gene uncharacterized LOC114678365 Neighboring gene 60S ribosomal protein L17 pseudogene Neighboring gene mannosidase beta Neighboring gene protein MANBAL pseudogene Neighboring gene 40S ribosomal protein S29 pseudogene Neighboring gene keratin, type II cytoskeletal 8 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rhesus monkey TRIM5α represses HIV-1 LTR promoter activity by negatively regulating TAK1/TAB1/TAB2/TAB3-complex-mediated NF-κB activation. Gong J, et al. Arch Virol, 2011 Nov. PMID 21918865
    2. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    3. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TRIM5alpha represses HIV-1 LTR promoter activity by negatively regulating TAK1/TAB1/TAB2/TAB3-complex-mediated NF-kappaB activation.
      Title: Rhesus monkey TRIM5α represses HIV-1 LTR promoter activity by negatively regulating TAK1/TAB1/TAB2/TAB3-complex-mediated NF-κB activation.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to stress IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in non-canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to cytokine IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nuclear factor NF-kappa-B p105 subunit
    Names
    nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001266053.1 → NP_001252982.1  nuclear factor NF-kappa-B p105 subunit

      See identical proteins and their annotated locations for NP_001252982.1

      Status: PROVISIONAL

      Source sequence(s)
      JV043229
      UniProtKB/TrEMBL
      A0A8J8Y2C4, F6S0D1, G7MTI9, H9Z1D5
      Related
      ENSMMUP00000004986.3, ENSMMUT00000005292.4
      Conserved Domains (7) summary
      cd07935
      Location:43 → 244
      RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)
      COG0666
      Location:484 → 706
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd01177
      Location:251 → 352
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
      cd08797
      Location:816 → 891
      Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
      sd00045
      Location:543 → 580
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:587 → 681
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:690 → 733
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041758.1 Reference Mmul_10 Primary Assembly

      Range
      100887542..101010961
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015138835.2 → XP_014994321.1  nuclear factor NF-kappa-B p105 subunit isoform X3

      UniProtKB/TrEMBL
      H9Z1D5, I2CVP9
      Conserved Domains (7) summary
      cd07935
      Location:42 → 243
      RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)
      COG0666
      Location:483 → 705
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd01177
      Location:250 → 351
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
      cd08797
      Location:815 → 890
      Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
      sd00045
      Location:542 → 579
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:586 → 680
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:689 → 732
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_028848098.1 → XP_028703931.1  nuclear factor NF-kappa-B p105 subunit isoform X4

      UniProtKB/TrEMBL
      H9Z1D5
      Conserved Domains (7) summary
      COG0666
      Location:352 → 574
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd01177
      Location:119 → 220
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
      cd08797
      Location:684 → 759
      Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
      sd00045
      Location:411 → 448
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:554 → 602
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:455 → 549
      Ank_2; Ankyrin repeats (3 copies)
      cl08275
      Location:1 → 112
      RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)

    3. XM_015138833.2 → XP_014994319.1  nuclear factor NF-kappa-B p105 subunit isoform X1

      UniProtKB/TrEMBL
      F7HKH9, H9Z1D5
      Related
      ENSMMUP00000034946.3, ENSMMUT00000041936.3
      Conserved Domains (7) summary
      cd07935
      Location:51 → 252
      RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)
      COG0666
      Location:492 → 714
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd01177
      Location:259 → 360
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
      cd08797
      Location:824 → 899
      Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
      sd00045
      Location:551 → 588
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:595 → 689
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:698 → 741
      Ank_2; Ankyrin repeats (3 copies)

    4. XM_015138834.2 → XP_014994320.1  nuclear factor NF-kappa-B p105 subunit isoform X2

      UniProtKB/TrEMBL
      H9Z1D5
      Conserved Domains (7) summary
      cd07935
      Location:50 → 251
      RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)
      COG0666
      Location:491 → 713
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd01177
      Location:258 → 359
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
      cd08797
      Location:823 → 898
      Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
      sd00045
      Location:550 → 587
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:594 → 688
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:697 → 740
      Ank_2; Ankyrin repeats (3 copies)

    5. XM_015138836.2 → XP_014994322.1  nuclear factor NF-kappa-B p105 subunit isoform X4

      UniProtKB/TrEMBL
      H9Z1D5
      Conserved Domains (7) summary
      COG0666
      Location:352 → 574
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd01177
      Location:119 → 220
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
      cd08797
      Location:684 → 759
      Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
      sd00045
      Location:411 → 448
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:554 → 602
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:455 → 549
      Ank_2; Ankyrin repeats (3 copies)
      cl08275
      Location:1 → 112
      RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)

    6. XM_015138837.2 → XP_014994323.1  nuclear factor NF-kappa-B p105 subunit isoform X4

      UniProtKB/TrEMBL
      H9Z1D5
      Conserved Domains (7) summary
      COG0666
      Location:352 → 574
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd01177
      Location:119 → 220
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
      cd08797
      Location:684 → 759
      Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
      sd00045
      Location:411 → 448
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:554 → 602
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:455 → 549
      Ank_2; Ankyrin repeats (3 copies)
      cl08275
      Location:1 → 112
      RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)

    7. XM_015138838.2 → XP_014994324.1  nuclear factor NF-kappa-B p105 subunit isoform X4

      UniProtKB/TrEMBL
      H9Z1D5
      Conserved Domains (7) summary
      COG0666
      Location:352 → 574
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd01177
      Location:119 → 220
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
      cd08797
      Location:684 → 759
      Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
      sd00045
      Location:411 → 448
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:554 → 602
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:455 → 549
      Ank_2; Ankyrin repeats (3 copies)
      cl08275
      Location:1 → 112
      RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)

    8. XM_028848099.1 → XP_028703932.1  nuclear factor NF-kappa-B p105 subunit isoform X4

      UniProtKB/TrEMBL
      H9Z1D5
      Conserved Domains (7) summary
      COG0666
      Location:352 → 574
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd01177
      Location:119 → 220
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
      cd08797
      Location:684 → 759
      Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
      sd00045
      Location:411 → 448
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:554 → 602
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:455 → 549
      Ank_2; Ankyrin repeats (3 copies)
      cl08275
      Location:1 → 112
      RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)
    Nucleotide Protein
    Heading Accession and Version

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