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    Trim69 tripartite motif-containing 69 [ Mus musculus (house mouse) ]

    Gene ID: 70928, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Trim69provided by MGI
    Official Full Name
    tripartite motif-containing 69provided by MGI
    Primary source
    MGI:MGI:1918178
    See related
    Ensembl:ENSMUSG00000033368 AllianceGenome:MGI:1918178
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Trif; Rnf36; Trimless; 4921519C19Rik
    Summary
    Predicted to enable identical protein binding activity and ubiquitin protein ligase activity. Predicted to be involved in innate immune response and protein localization to centrosome. Predicted to be located in nuclear speck. Predicted to be active in centrosome and cytoplasm. Is expressed in central nervous system. Orthologous to human TRIM69 (tripartite motif containing 69). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 46.9) See more
    Orthologs
    human all
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    Genomic context

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    See Trim69 in Genome Data Viewer
    Location:
    2 E5; 2 60.55 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (121991189..122009503)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (122160708..122179022)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 3, subunit J1 Neighboring gene SPG11, spatacsin vesicle trafficking associated Neighboring gene STARR-seq mESC enhancer starr_05546 Neighboring gene protein associated with topoisomerase II homolog 2 (yeast) Neighboring gene STARR-positive B cell enhancer ABC_E512 Neighboring gene STARR-seq mESC enhancer starr_05550 Neighboring gene beta-2 microglobulin Neighboring gene telomere repeat binding bouquet formation protein 2 Neighboring gene ATP synthase F(0) complex subunit C1, mitochondrial pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The testis-specifically expressed gene Trim69 is not essential for fertility in mice. He X, et al. J Biomed Res, 2020 Aug 21. PMID 33273151, Free PMC Article
    2. Targeting Trim69 alleviates high fat diet (HFD)-induced hippocampal injury in mice by inhibiting apoptosis and inflammation through ASK1 inactivation. Li LJ, et al. Biochem Biophys Res Commun, 2019 Aug 6. PMID 31178136
    3. A novel member of the RBCC family, Trif, expressed specifically in the spermatids of mouse testis. Shyu HW, et al. Mech Dev, 2001 Oct. PMID 11578878
    4. Forced expression of RNF36 induces cell apoptosis. Shyu HW, et al. Exp Cell Res, 2003 Jul 15. PMID 12837286
    5. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Trim69 might be a functionally essential inhibitor of ASK1 activation during the pathogenesis of hippocampal inflammation and apoptosis
      Title: Targeting Trim69 alleviates high fat diet (HFD)-induced hippocampal injury in mice by inhibiting apoptosis and inflammation through ASK1 inactivation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase TRIM69
    Names
    RFP-like (B30.2) domain protein
    RING finger B-box coiled-coil transcription factor
    RING-type E3 ubiquitin transferase TRIM69
    ring finger protein 36
    testis-specific RING finger protein
    tripartite motif-containing protein 69
    NP_001366298.1
    NP_536771.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001379369.1 → NP_001366298.1  E3 ubiquitin-protein ligase TRIM69 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL844573, AL845457
      Conserved Domains (4) summary
      PLN03208
      Location:17 → 134
      PLN03208; E3 ubiquitin-protein ligase RMA2; Provisional
      COG1196
      Location:136 → 272
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl02614
      Location:294 → 479
      SPRY; SPRY domain
      cl17238
      Location:21 → 65
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    2. NM_080510.3 → NP_536771.2  E3 ubiquitin-protein ligase TRIM69 isoform 1

      See identical proteins and their annotated locations for NP_536771.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AL844573, AL845457
      Consensus CDS
      CCDS16655.1
      UniProtKB/Swiss-Prot
      Q80X56, Q8VHZ6
      Related
      ENSMUSP00000047627.8, ENSMUST00000036089.8
      Conserved Domains (2) summary
      cl02614
      Location:312 → 497
      SPRY; SPRY domain
      cl17238
      Location:42 → 82
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RNA

    1. NR_166637.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL844573, AL845457

    2. NR_166638.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL844573, AL845457

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      121991189..122009503
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80X56.1 GenPept UniProtKB/Swiss-Prot:Q80X56

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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