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    TRAF2 TNF receptor associated factor 2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 708391, updated on 17-Aug-2024

    Summary

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    Official Symbol
    TRAF2provided by VGNC
    Official Full Name
    TNF receptor associated factor 2provided by VGNC
    Primary source
    VGNC:VGNC:78641
    See related
    Ensembl:ENSMMUG00000011527
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See TRAF2 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 15 NC_041768.1 (1286874..1332170, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 15 NC_027907.1 (1360201..1405808, complement)

    Chromosome 15 - NC_041768.1Genomic Context describing neighboring genes Neighboring gene complement C8 gamma chain Neighboring gene F-box and WD repeat domain containing 5 Neighboring gene endothelial differentiation related factor 1 Neighboring gene MAM domain containing 4 Neighboring gene phosphohistidine phosphatase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables tumor necrosis factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in activation of NF-kappaB-inducing kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of JNK cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein K63-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein autoubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in tumor necrosis factor-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of plasma membrane signaling receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    TNF receptor-associated factor 2
    NP_001181721.1
    XP_001092078.1
    XP_001092203.1
    XP_014971792.1
    XP_014971794.1
    XP_014971795.1
    XP_014971796.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001194792.3 → NP_001181721.1  TNF receptor-associated factor 2

      Status: PROVISIONAL

      Source sequence(s)
      QNVO02000131
      UniProtKB/TrEMBL
      H9EUU8
      Conserved Domains (3) summary
      cd03778
      Location:323 → 486
      MATH_TRAF2; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF2 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
      pfam02176
      Location:167 → 224
      zf-TRAF; TRAF-type zinc finger
      pfam16673
      Location:256 → 318
      TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041768.1 Reference Mmul_10 Primary Assembly

      Range
      1286874..1332170 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001092078.4 → XP_001092078.1  TNF receptor-associated factor 2 isoform X1

      See identical proteins and their annotated locations for XP_001092078.1

      UniProtKB/TrEMBL
      H9EUU8, H9Z138
      Related
      ENSMMUP00000015133.3, ENSMMUT00000016146.4
      Conserved Domains (5) summary
      cd03778
      Location:334 → 497
      MATH_TRAF2; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF2 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
      TIGR00599
      Location:28 → 157
      rad18; DNA repair protein rad18
      pfam02176
      Location:178 → 235
      zf-TRAF; TRAF-type zinc finger
      cd16639
      Location:32 → 73
      RING-HC_TRAF2; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and similar proteins
      pfam16673
      Location:269 → 329
      TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain

    2. XM_001092203.4 → XP_001092203.1  TNF receptor-associated factor 2 isoform X1

      See identical proteins and their annotated locations for XP_001092203.1

      UniProtKB/TrEMBL
      H9EUU8, H9Z138
      Conserved Domains (5) summary
      cd03778
      Location:334 → 497
      MATH_TRAF2; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF2 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
      TIGR00599
      Location:28 → 157
      rad18; DNA repair protein rad18
      pfam02176
      Location:178 → 235
      zf-TRAF; TRAF-type zinc finger
      cd16639
      Location:32 → 73
      RING-HC_TRAF2; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and similar proteins
      pfam16673
      Location:269 → 329
      TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain

    3. XM_015116308.2 → XP_014971794.1  TNF receptor-associated factor 2 isoform X2

      UniProtKB/TrEMBL
      A0A5F8ADX3, H9EUU8
      Conserved Domains (4) summary
      cd03778
      Location:301 → 464
      MATH_TRAF2; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF2 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
      pfam00097
      Location:34 → 72
      zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
      pfam02176
      Location:145 → 202
      zf-TRAF; TRAF-type zinc finger
      pfam16673
      Location:234 → 296
      TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain

    4. XM_015116306.2 → XP_014971792.1  TNF receptor-associated factor 2 isoform X1

      UniProtKB/TrEMBL
      H9EUU8, H9Z138
      Related
      ENSMMUP00000075835.1, ENSMMUT00000092436.1
      Conserved Domains (5) summary
      cd03778
      Location:334 → 497
      MATH_TRAF2; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF2 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
      TIGR00599
      Location:28 → 157
      rad18; DNA repair protein rad18
      pfam02176
      Location:178 → 235
      zf-TRAF; TRAF-type zinc finger
      cd16639
      Location:32 → 73
      RING-HC_TRAF2; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and similar proteins
      pfam16673
      Location:269 → 329
      TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain

    5. XM_015116309.2 → XP_014971795.1  TNF receptor-associated factor 2 isoform X2

      UniProtKB/TrEMBL
      A0A5F8ADX3, H9EUU8
      Related
      ENSMMUP00000076072.1, ENSMMUT00000103251.1
      Conserved Domains (4) summary
      cd03778
      Location:301 → 464
      MATH_TRAF2; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF2 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
      pfam00097
      Location:34 → 72
      zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
      pfam02176
      Location:145 → 202
      zf-TRAF; TRAF-type zinc finger
      pfam16673
      Location:234 → 296
      TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain

    6. XM_015116310.2 → XP_014971796.1  TNF receptor-associated factor 2 isoform X3

      UniProtKB/TrEMBL
      H9EUU8
      Conserved Domains (3) summary
      cd03778
      Location:282 → 445
      MATH_TRAF2; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF2 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
      pfam02176
      Location:126 → 183
      zf-TRAF; TRAF-type zinc finger
      pfam16673
      Location:215 → 277
      TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
    Nucleotide Protein
    Heading Accession and Version

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