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    P2ry12 purinergic receptor P2Y, G-protein coupled 12 [ Mus musculus (house mouse) ]

    Gene ID: 70839, updated on 27-Nov-2024

    Summary

    Official Symbol
    P2ry12provided by MGI
    Official Full Name
    purinergic receptor P2Y, G-protein coupled 12provided by MGI
    Primary source
    MGI:MGI:1918089
    See related
    Ensembl:ENSMUSG00000036353 AllianceGenome:MGI:1918089
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P2Y12; 2900079B22Rik; 4921504D23Rik
    Summary
    Enables G protein-coupled ADP receptor activity and G protein-coupled adenosine receptor activity. Involved in several processes, including cellular response to ATP; regulation of microglial cell migration; and substrate-dependent cell migration, cell extension. Acts upstream of or within several processes, including adenylate cyclase-modulating G protein-coupled receptor signaling pathway; platelet activation; and positive regulation of monoatomic ion transport. Located in cell body membrane and cell projection membrane. Is expressed in central nervous system and cerebral cortex. Used to study platelet-type bleeding disorder 8. Human ortholog(s) of this gene implicated in asthma; cerebrovascular disease; peripheral artery disease; platelet-type bleeding disorder 8; and type 2 diabetes mellitus. Orthologous to human P2RY12 (purinergic receptor P2Y12). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cortex adult (RPKM 10.9), frontal lobe adult (RPKM 10.2) and 15 other tissues See more
    Orthologs
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    Genomic context

    See P2ry12 in Genome Data Viewer
    Location:
    3 D; 3 29.01 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (59123692..59170408, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (59216271..59262985, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 12-like Neighboring gene STARR-seq mESC enhancer starr_07765 Neighboring gene predicted gene, 51434 Neighboring gene G protein-coupled receptor 87 Neighboring gene purinergic receptor P2Y, G-protein coupled 13 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:59062055-59062302 Neighboring gene STARR-seq mESC enhancer starr_07766 Neighboring gene immunoglobulin superfamily, member 10 Neighboring gene poly(A) binding protein, cytoplasmic 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled ADP receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables G protein-coupled ADP receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables G protein-coupled adenosine receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables G protein-coupled purinergic nucleotide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled adenosine receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in G protein-coupled adenosine receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in G protein-coupled purinergic nucleotide receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within adenylate cyclase-modulating G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell projection organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to ATP IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to ATP ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to organic cyclic compound IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cerebral cortex radial glia-guided migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of establishment of localization in cell IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in glial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of monoatomic ion transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of norepinephrine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within platelet activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in platelet aggregation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in platelet aggregation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell adhesion mediated by integrin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of integrin activation by cell surface receptor linked signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of microglial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of monoatomic ion transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ruffle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of microglial cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to axon injury ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in substrate-dependent cell migration, cell extension IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in visual system development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in basal plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in caveola ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell body membrane IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    located_in cell projection membrane IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane IC
    Inferred by Curator
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357007.1NP_001343936.1  P2Y purinoceptor 12

      Status: VALIDATED

      Source sequence(s)
      AC122038, CN691066
      Consensus CDS
      CCDS17373.1
      UniProtKB/Swiss-Prot
      Q9CPV9
      UniProtKB/TrEMBL
      Q546L4, Q8BZV8
      Related
      ENSMUSP00000143521.2, ENSMUST00000199609.2
      Conserved Domains (1) summary
      cd15150
      Location:32315
      7tmA_P2Y12; P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. NM_001357008.1NP_001343937.1  P2Y purinoceptor 12

      Status: VALIDATED

      Source sequence(s)
      AC122038
      Consensus CDS
      CCDS17373.1
      UniProtKB/Swiss-Prot
      Q9CPV9
      UniProtKB/TrEMBL
      Q546L4, Q8BZV8
      Related
      ENSMUSP00000143036.2, ENSMUST00000196583.5
      Conserved Domains (1) summary
      cd15150
      Location:32315
      7tmA_P2Y12; P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors
    3. NM_001357010.1NP_001343939.1  P2Y purinoceptor 12

      Status: VALIDATED

      Source sequence(s)
      AC122038
      Consensus CDS
      CCDS17373.1
      UniProtKB/Swiss-Prot
      Q9CPV9
      UniProtKB/TrEMBL
      Q546L4, Q8BZV8
      Related
      ENSMUSP00000126819.2, ENSMUST00000170388.6
      Conserved Domains (1) summary
      cd15150
      Location:32315
      7tmA_P2Y12; P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors
    4. NM_027571.4NP_081847.3  P2Y purinoceptor 12

      See identical proteins and their annotated locations for NP_081847.3

      Status: VALIDATED

      Source sequence(s)
      AC122038, AK013804, AK014807, AK033448
      Consensus CDS
      CCDS17373.1
      UniProtKB/Swiss-Prot
      Q9CPV9
      UniProtKB/TrEMBL
      Q546L4, Q8BZV8
      Related
      ENSMUSP00000051353.8, ENSMUST00000050360.14
      Conserved Domains (1) summary
      cd15150
      Location:32315
      7tmA_P2Y12; P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      59123692..59170408 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163310.1XP_036019203.1  P2Y purinoceptor 12 isoform X1

      UniProtKB/Swiss-Prot
      Q9CPV9
      UniProtKB/TrEMBL
      Q546L4, Q8BZV8
      Conserved Domains (1) summary
      cd15150
      Location:32315
      7tmA_P2Y12; P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. XM_036163311.1XP_036019204.1  P2Y purinoceptor 12 isoform X1

      UniProtKB/Swiss-Prot
      Q9CPV9
      UniProtKB/TrEMBL
      Q546L4, Q8BZV8
      Conserved Domains (1) summary
      cd15150
      Location:32315
      7tmA_P2Y12; P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors