APC2 APC regulator of WNT signaling pathway 2 [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: APC2provided by VGNC
Official Full Name: APC regulator of WNT signaling pathway 2provided by VGNC
Primary source: VGNC:VGNC:69888
See related: Ensembl:ENSMMUG00000003053
Gene type: protein coding
RefSeq status: MODEL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	19	NC_041772.1 (1239016..1266638)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	19	NC_027911.1 (1247697..1275272)

Chromosome 19 - NC_041772.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH36570 (e-PCR)
- UniSTS:49911

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables beta-catenin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables gamma-catenin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables microtubule binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell fate specification	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell migration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of microtubule depolymerization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in pattern specification process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of protein catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of beta-catenin destruction complex	IEA Inferred from Electronic Annotation more info	PubMed
part_of catenin complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytoplasmic microtubule	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: adenomatous polyposis coli protein 2

Names: APC2, WNT signaling pathway regulator

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

NC_041772.1 Reference Mmul_10 Primary Assembly

Range

1239016..1266638

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015122353.2 → XP_014977839.1 adenomatous polyposis coli protein 2 isoform X2

UniProtKB/TrEMBL

I2CYF3

Conserved Domains (8) summary

cd00020
Location:600 → 718

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

pfam05923
Location:1284 → 1305

APC_crr; APC cysteine-rich region

pfam05924
Location:1650 → 1667

SAMP; SAMP Motif

pfam05956
Location:1810 → 2134

APC_basic; APC basic domain

pfam11414
Location:148 → 229

Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein

pfam16629
Location:721 → 968

Arm_APC_u3; Armadillo-associated region on APC

pfam16689
Location:30 → 81

APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain

sd00043
Location:551 → 584

ARM; armadillo repeat [structural motif]
XM_015122354.2 → XP_014977840.1 adenomatous polyposis coli protein 2 isoform X3

UniProtKB/TrEMBL

F6VET0, I2CYF3

Related

ENSMMUP00000004073.4, ENSMMUT00000004321.4

Conserved Domains (8) summary

cd00020
Location:599 → 717

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

pfam05923
Location:1283 → 1304

APC_crr; APC cysteine-rich region

pfam05924
Location:1649 → 1666

SAMP; SAMP Motif

pfam05956
Location:1809 → 2133

APC_basic; APC basic domain

pfam11414
Location:148 → 228

Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein

pfam16629
Location:720 → 967

Arm_APC_u3; Armadillo-associated region on APC

pfam16689
Location:30 → 81

APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain

sd00043
Location:550 → 583

ARM; armadillo repeat [structural motif]
XM_015122352.2 → XP_014977838.2 adenomatous polyposis coli protein 2 isoform X1

UniProtKB/TrEMBL

I2CYF3

Conserved Domains (11) summary

smart00185
Location:697 → 737

ARM; Armadillo/beta-catenin-like repeats

PHA03247
Location:1597 → 2051

PHA03247; large tegument protein UL36; Provisional

PRK07764
Location:2131 → 2380

PRK07764; DNA polymerase III subunits gamma and tau; Validated

PRK12323
Location:1432 → 1658

PRK12323; DNA polymerase III subunits gamma and tau; Provisional

pfam16689
Location:89 → 140

APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain

sd00043
Location:610 → 643

ARM; armadillo repeat [structural motif]

pfam05956
Location:1869 → 2196

APC_basic; APC basic domain

pfam10473
Location:65 → 169

CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1

pfam11414
Location:207 → 288

Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein

pfam16629
Location:780 → 1027

Arm_APC_u3; Armadillo-associated region on APC

pfam05923
Location:1343 → 1364

APC_r; APC repeat