Dusp16 dual specificity phosphatase 16 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dusp16provided by MGI
Official Full Name: dual specificity phosphatase 16provided by MGI
Primary source: MGI:MGI:1917936
See related: Ensembl:ENSMUSG00000030203 AllianceGenome:MGI:1917936
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MKP7; Mkpm; MKP-7; D6Ertd213e; 3830417M17Rik
Summary: Predicted to enable phosphoprotein phosphatase activity; protein carrier chaperone; and protein kinase binding activity. Predicted to be involved in dephosphorylation; negative regulation of MAPK cascade; and signal transduction. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human DUSP16 (dual specificity phosphatase 16). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 11.4), mammary gland adult (RPKM 7.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 G1; 6 65.77 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (134692431..134769687, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (134715468..134807063, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Targeting DUSP16/TAK1 signaling alleviates hepatic dyslipidemia and inflammation in high fat diet (HFD)-challenged mice through suppressing JNK MAPK.
Title: Targeting DUSP16/TAK1 signaling alleviates hepatic dyslipidemia and inflammation in high fat diet (HFD)-challenged mice through suppressing JNK MAPK.
Studies in knockout mice show that DUSP16 is an endogenous regulator of OPN-type osteoblast differentiation, via JNK dephosphorylation by DUSP16.
Title: JNK inactivation suppresses osteogenic differentiation, but robustly induces osteopontin expression in osteoblasts through the induction of inhibitor of DNA binding 4 (Id4).
Ablation of Dusp16 enhanced axonal degeneration in response to trophic withdrawal, suggesting that it has a protective function. Moreover, axonal skin innervation was severely reduced while neuronal elimination was increased in the Dusp16 knockout. Mechanistically, Dusp16 negatively regulates the transcription factor p53 and antagonizes the expression of the pro-degenerative factor, Puma.
Title: Axonal Degeneration Is Regulated by a Transcriptional Program that Coordinates Expression of Pro- and Anti-degenerative Factors.
MAPK phosphatase 7 regulates T cell differentiation via inhibiting ERK-mediated IL-2 expression.
Title: MAPK phosphatase 7 regulates T cell differentiation via inhibiting ERK-mediated IL-2 expression.
ADCY5 repression by miR-17 facilitated the translocation of EGFR and MKP7 from membrane into cytoplasmic and mitochondrial fractions.
Title: miR-17 extends mouse lifespan by inhibiting senescence signaling mediated by MKP7.
Production of IL-10 and its inhibitory effect on IL-12 production were unaltered in Dusp16tp/tp macrophages.
Title: Gene trap mice reveal an essential function of dual specificity phosphatase Dusp16/MKP-7 in perinatal survival and regulation of Toll-like receptor (TLR)-induced cytokine production.
the functional role of DUSP16 in Th1/Th2 balance.
Title: Functional involvement of dual specificity phosphatase 16 (DUSP16), a c-Jun N-terminal kinase-specific phosphatase, in the regulation of T helper cell differentiation.
the contrasting effects of acute and chronic stress on insulin sensitivity are driven by changes in subcellular distribution of MKP7 and activated JNK
Title: Acute oxidative stress can reverse insulin resistance by inactivation of cytoplasmic JNK.
DUSP16 is an important regulator of JNK activity and effector functions of CD4 and CD8 T cells.
Title: Dual specificity phosphatase16 is a negative regulator of c-Jun NH2-terminal kinase activity in T cells.
JIP-1 targets MKP-7 to dephosphorylate JNK.
Title: The JNK-interacting protein-1 scaffold protein targets MAPK phosphatase-7 to dephosphorylate JNK.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (2)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW558566 (e-PCR)
- UniSTS:179504

RH126445 (e-PCR)
- UniSTS:163153

Dusp16 (e-PCR), detects polymorphism
- UniSTS:546747

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables JUN kinase binding	ISO Inferred from Sequence Orthology more info
enables MAP kinase tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP kinase tyrosine/serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables mitogen-activated protein kinase binding	ISO Inferred from Sequence Orthology more info
enables mitogen-activated protein kinase p38 binding	ISO Inferred from Sequence Orthology more info
enables phosphatase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables phosphoprotein phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein carrier chaperone	ISO Inferred from Sequence Orthology more info
enables protein tyrosine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: dual specificity protein phosphatase 16

Names: MAP kinase phosphatase-7; map kinase phosphatase-M

NP_001041519.1

EC 3.1.3.16

EC 3.1.3.48

NP_569714.2

EC 3.1.3.16

EC 3.1.3.48

XP_036008191.1

EC 3.1.3.16

EC 3.1.3.48

XP_036008192.1

EC 3.1.3.16

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001048054.2 → NP_001041519.1 dual specificity protein phosphatase 16 isoform B1

Status: VALIDATED

Description

Transcript Variant: This variant (B1) uses an alternate in-frame splice site in the 3' terminal exon, compared to variant A1. It encodes isoform B1, which lacks an internal segment and is shorter, compared to isoform A1.

Source sequence(s)

AC122193, AC126692, BE851024, CA751341, CF733313, CN695929, CV557369

Consensus CDS

CCDS85175.1

UniProtKB/TrEMBL

F6UIK0, Q3UMM5

Related

ENSMUSP00000115925.3, ENSMUST00000129433.4

Conserved Domains (2) summary

cd00127
Location:158 → 272

DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

cd01446
Location:10 → 136

DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
NM_130447.3 → NP_569714.2 dual specificity protein phosphatase 16 isoform A1

See identical proteins and their annotated locations for NP_569714.2

Status: VALIDATED

Description

Transcript Variant: This variant (A1) represents the longer transcript and encodes the longer isoform (A1).

Source sequence(s)

AC122193, AC126692, BC057321

Consensus CDS

CCDS39679.1

UniProtKB/TrEMBL

Q6PCP3, Q920R2

Related

ENSMUSP00000098419.4, ENSMUST00000100857.10

Conserved Domains (2) summary

cd01446
Location:10 → 136

DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

cl28904
Location:157 → 301

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

134692431..134769687 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036152299.1 → XP_036008192.1 dual specificity protein phosphatase 16 isoform X1

UniProtKB/TrEMBL

Q6PCP3, Q920R2

Conserved Domains (2) summary

cd01446
Location:10 → 136

DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

cl28904
Location:157 → 301

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_036152298.1 → XP_036008191.1 dual specificity protein phosphatase 16 isoform X1

UniProtKB/TrEMBL

Q6PCP3, Q920R2

Conserved Domains (2) summary

cd01446
Location:10 → 136

DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

cl28904
Location:157 → 301

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_181320.2: Suppressed sequence

Description

NM_181320.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.