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    IKBKB inhibitor of nuclear factor kappa B kinase subunit beta [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 704683, updated on 17-Aug-2024

    Summary

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    Official Symbol
    IKBKBprovided by VGNC
    Official Full Name
    inhibitor of nuclear factor kappa B kinase subunit betaprovided by VGNC
    Primary source
    VGNC:VGNC:84006
    Locus tag
    EGK_18890
    See related
    Ensembl:ENSMMUG00000008351
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See IKBKB in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 8 NC_041761.1 (42871230..42929398)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 8 NC_027900.1 (42370102..42428256, complement)

    Chromosome 8 - NC_041761.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene U1 spliceosomal RNA Neighboring gene 60S ribosomal protein L5 pseudogene Neighboring gene DNA polymerase beta Neighboring gene dickkopf WNT signaling pathway inhibitor 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables IkappaB kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in tumor necrosis factor-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of IkappaB kinase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    inhibitor of nuclear factor kappa-B kinase subunit beta
    Names
    inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
    NP_001252875.1
    XP_015000721.1
    XP_015000722.1
    XP_015000723.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001265946.1 → NP_001252875.1  inhibitor of nuclear factor kappa-B kinase subunit beta

      See identical proteins and their annotated locations for NP_001252875.1

      Status: PROVISIONAL

      Source sequence(s)
      JV046971
      UniProtKB/TrEMBL
      A0A8J8XBD7, F6SHC1, G7MZ74, H9FU03
      Related
      ENSMMUP00000032125.2, ENSMMUT00000039043.3
      Conserved Domains (4) summary
      cd14038
      Location:20 → 309
      STKc_IKK_beta; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) beta
      cd17046
      Location:310 → 390
      Ubl_IKKA_like; ubiquitin-like (Ubl) domain found in inhibitor of nuclear factor kappa-B kinases, IKK-alpha and IKK-beta, and similar proteins
      pfam12179
      Location:708 → 742
      IKKbetaNEMObind; I-kappa-kinase-beta NEMO binding domain
      pfam18397
      Location:389 → 663
      IKBKB_SDD; IQBAL scaffold dimerization domain

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041761.1 Reference Mmul_10 Primary Assembly

      Range
      42871230..42929398
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015145237.1 → XP_015000723.1  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X3

      UniProtKB/TrEMBL
      H9FU03
      Conserved Domains (4) summary
      cd17046
      Location:251 → 331
      Ubl_IKKA_like; ubiquitin-like (Ubl) domain found in inhibitor of nuclear factor kappa-B kinases, IKK-alpha and IKK-beta, and similar proteins
      pfam12179
      Location:649 → 683
      IKKbetaNEMObind; I-kappa-kinase-beta NEMO binding domain
      pfam18397
      Location:330 → 604
      IKBKB_SDD; IQBAL scaffold dimerization domain
      cl21453
      Location:8 → 250
      PKc_like; Protein Kinases, catalytic domain

    2. XM_015145235.2 → XP_015000721.1  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1

      UniProtKB/TrEMBL
      H9FU03
      Conserved Domains (3) summary
      cd14038
      Location:20 → 309
      STKc_IKK_beta; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) beta
      cd17046
      Location:310 → 390
      Ubl_IKKA_like; ubiquitin-like (Ubl) domain found in inhibitor of nuclear factor kappa-B kinases, IKK-alpha and IKK-beta, and similar proteins
      pfam18397
      Location:389 → 663
      IKBKB_SDD; IQBAL scaffold dimerization domain

    3. XM_015145236.2 → XP_015000722.1  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2

      UniProtKB/TrEMBL
      H9FU03
      Conserved Domains (3) summary
      cd17046
      Location:251 → 331
      Ubl_IKKA_like; ubiquitin-like (Ubl) domain found in inhibitor of nuclear factor kappa-B kinases, IKK-alpha and IKK-beta, and similar proteins
      pfam18397
      Location:330 → 604
      IKBKB_SDD; IQBAL scaffold dimerization domain
      cl21453
      Location:8 → 250
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version

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